SK-BR-3
<p>EP3 receptor antagonist L798,106 reduces proliferation and migration of SK-BR-3 breast cancer cells</p>
... the SK-BR-3 cell line, however, EP3 antagonism led to signi fi cantly reduced proliferation and migration rates compared to unstimulated ...effects, SK-BR-3 breast cancer cells ...
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Silibinin: An Inhibitor of Mir-181a Gene Expression in Sk-Br-3 Breast Cancer Cell Line
... SK-BR-3 cells were plated in 6 well plate under the standard culture conditions. After 48 h of incubation, the cells were fed with fresh medium and treated with DMSO alone or administered with ...
6
PRODUCTIO N OF PROSTATE-SPECIFIC ANTIGEN (PSA) BY A BREAST CANCER CELL LINE, SK-Br-3
... lines, SK-Br-3 and ...the Sk-Br-3 cell line was detected by western blotting and immunoperoxidase, ...in Sk-Br-3 than non-PSA producer breast cancer cell ...
6
Lists in a Lighthouse
... In addition, we generated the electrospun polycaprolactone (PCL) microfibers for three dimensional (3D) culture of breast cancer cell lines, MCF-7. We found that cancer stem cells (CSCs), a small group of ...
136
miR-1296-5p decreases ERBB2 expression to inhibit the cell proliferation in ERBB2-positive breast cancer
... In this study, we find that miR-1296-5p expression is suppressed in a majority of breast cancer samples when compared to normal breast samples. Previous study has showed that the expression level of miR-1296 is Fig. 1 ...
8
Study of the Effect of Silymarin on Viability of Breast Cancer Cell Lines
... In the present study, cell viability was significantly reduced in comparison to the controls. This effect in- creased over the time course from 24 - 72 hours, and also from lower to higher concentrations of Silymarin ...
7
Silicon particles as trojan horses for potential cancer therapy
... reduced from the oxidized to the reduced form, resofurin, by metabolically active cells. Resofurin is fluorescent, has a maximum emission wavelength at 585 nm (red emission), and can be excited from 530 to 560 nm. The ...
10
Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes
... as a therapeutic target [33]. DHRS2 (dehydrogenase/ reductase SDR family member 2) metabolizes a vari- ety of steroids and other cellular components and was highly and exclusively expressed in ...
9
Near-infrared quantum dots for HER2 localization and imaging of cancer cells
... the SK-BR-3 cells clearly showed evidence of intracellular uptake with marked red fluorescence, unlike MCF7 cells, that showed a significantly lower uptake due to reduced expres- sion of HER2 ...
15
Original Article Effects of chitosan nanoparticle carrier-mediated small-interfering RNA silencing of SUMO-specific protease 1 on in vitro migration of breast cancer cells
... One day before transfection, SK-BR-3 cells were inoculated onto 6-well plates and divided into four groups after 80% confluence. (1) Experimental group that was transfected with chitosan-SENP1 siRNA ...
6
Cleavage of the extracellular domain of junctional adhesion molecule A is associated with resistance to anti HER2 therapies in breast cancer settings
... drug-sensitive SK-BR-3 cells in vitro and a semi- in vivo model. SK-BR-3 – sensitive (SK-BR- 3-Sens) cells (100,000) were plated per well in six-well plates ...
18
Lin28A activates androgen receptor via regulation of c-myc and promotes malignancy of ER−/Her2+ breast cancer
... and SK-BR-3 cells had over-expression of Her2 and low- expression of ER ...and SK-BR-3 cell lines has been previously reported [30, 31] and provide a valid model for the ...Inc). ...
12
Murine precision-cut liver slices (PCLS): a new tool for studying tumor microenvironments and cell signaling ex vivo
... and SK-BR-3 cells, because both were isolated from pleural effusion but not from ...than SK-BR-3 cells using the Boyden chamber in vitro system ...procedure 3 and Figure ...
13
Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia
... After the indicated treatment, MDA-MB-453 and SK- BR-3 cells were collected and lysed in RIPA lysis buffer (Beyotime, Shanghai, China). The lysates were centri- fuged at 12,000 g for 10 min and then ...
12
Genetically Encoded Immunophotosensitizer 4D5scFv-miniSOG is a Highly Selective Agent for Targeted Photokilling of Tumor Cells in Vitro
... experiments. SK-BR-3 cells were treated with various concentrations of 4D5scFv-miniSOG and 1 μM of Taxol, and the percentage of viable cells relative to the immunoPS/drug-free control was ...
10
HER2 reduces breast cancer radiosensitivity by activating focal adhesion kinase in vitro and in vivo
... and SK-BR-3 for the silencing of ...approximately 3- to 10-fold of the control (A); the relative levels of HER2 mRNA expression of SK-BR-3 Her2i and ZR-7530 Her2i were ...
13
Anti-neoplastic effects of aprotinin on human breast cancer cell lines: In vitro study
... Results. Cancer cell lines showed more invasion characteristics compared to HDF-1. Aprotinin significantly decreased the invasiveness of MDA-MB-231 in concentrations of 1 trypsin inhibitor unit (TIU)/mL, 1.3 TIU/mL and ...
7
Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells
... (Figure 3, G and H, and Supplemental Figure 3, G and ...(Figure 3, J and K) and SK-BR-3 (Supplemental Figure 3, J and K) ...Figure 3, L and M), suggesting that ...
21
Original Article Detection of HER2 positive circulating tumor cells using anti-HER2-renilla luciferase fusion protein
... To investigate whether anti-HER2-RLuc retained both HER2-binding and enzymatic light signal- producing activity, we first identified the HER2 protein expression level in two cell lines (Figure 2A). We then found a ...
14
The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling
... murine SK-BR-3 breast cancer xenograft model, we observed that co-administration of L-NIL with LAP-plus-DOX resulted in reduced cardiac injury and dysfunction without compromising the anti-cancer ...
13