SKBR3 Breast Cancer Cells
Copolymer micelles function as pH-responsive nanocarriers to enhance the cytotoxicity of a HER2 aptamer in HER2-positive breast cancer cells
... target cells is crucial for nucleic acid-based ...in SKBR3 breast cancer cells, which overexpress ...MCF7 breast cancer cells, which express low levels of ...in ...
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Nucleolin-binding by ErbB2 enhances tumorigenicity of ErbB2- positive breast cancer
... We have discovered that formation of nucleolin- ErbB2 complexes results in phosphorylation of ErbB2, and the downstream activation of the MAPK pathway, but not the PI3K pathway. Importantly, depletion of endogenous ...
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Anti-Mucin1 Aptamer-Conjugated Chitosan Nanoparticles for Targeted Co-Delivery of Docetaxel and IGF-1R siRNA to SKBR3 Metastatic Breast Cancer Cells
... The SKBR3 and CHO cell lines were obtained from the National Cell Bank of Iran (Pasteur Institute of Iran, Tehran, Iran), DTX from AQVida ® (Hamburg, Germany), and human IGF-1Rα/β siRNA (sc-29358) and scrambled ...
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<p>Fenofibrate potentiates chemosensitivity to human breast cancer cells by modulating apoptosis via AKT/NF-κB pathway</p>
... AKT/NF- κ B signaling pathways are involved in fenofibrate- induced apoptosis, we checked phosphorylated AKT/NF- κ B by Western blotting (Figure 5A). Fenofibrate treatment sig- nificantly decreased the level of ...
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The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer
... in breast cancer cell lines established from HER2-positive breast cancer cells cultured in the presence of trastuzumab, including the HER2-positive SKBR3 cell line [15, 16, ...
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BU 32: a novel proteasome inhibitor for breast cancer
... and SKBR3 cell lines, and compared the effect with that of ...endothelial cells increases with the angiogenic switch and persists throughout angiogenesis - except during vessel stabilization, when ...
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Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition
... of cancer glucose ...three breast cancer cells, BT474, SKBR3 and MCF7 ...human breast can- cer patient samples compared with their adjacent normal tissues ...resistant ...
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Original Article Overexpression of long non-coding RNA HOTAIR enhances breast cancer radioresistance via RhoC-Akt pathway by targeting HOXD10
... HOTAIR-overexpression breast tumors have a low sensitivity to radiotherapy by inter- fering with the activation of HOXD10 and PI3K/ AKT-Bad ...resisted SKBR3 to IR in Vivo (A and ...vector SKBR3 ...
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Original Article Phosphatase and tensin homolog regulates microRNA-182 and AKT to induce apoptosis of breast cancer cells SKBR3
... Abstract: Breast cancer is a disease of high incidence impacting the health of numerous female ...in breast cancer cell apoptosis, however, the underlying mecha- nism is largely ...in ...
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Peroxiredoxin 1 protects estrogen receptor α from oxidative stress induced suppression and is a protein biomarker of favorable prognosis in breast cancer
... in breast cancer, a funda- mental step for our study was comprehensive validation of the anti-PRDX1 ...several breast cancer cell lines (T47D, ZR-75-1 and SKBR3), whereby PRDX1 ...
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Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer
... B), SKBR3 (ER−/HER2+, HER2-amplified) and MDA-MB-231 (ER−/progesterone receptor–negative [PR−]/HER2−, triple-negative), and they were exposed to increasing concentrations of epirubicin until resistant cells ...
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... and breast (SKBr3) cancer cells to exhibit anchorage-independent growth, while its depletion determined morphological change to a large and flat epithelial ...sporadic breast cancers ...
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The Evaluation of the Effects of Temozolomide on MGMT Gene Expression in MCF 7 and SKBR3 Human Breast Cancer Cell Lines
... MCF-7 cells by ...MCF-7 cells were exposed to TMZ for 4 days, MGMT expression was inhibited by TMZ ...els. SKBR3 cell line has a homozygous mutant character for P53 gene in terms of its general ...
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Human breast cancer cells educate macrophages toward the M2 activation status
... negative breast cancer patients should be made with ...while cancer cells from triple-negative breast tumors, which can be of seven dif- ferent subtypes, have phenotypic diversity from ...
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Breast cancer cells obtain an osteomimetic feature via epithelial- mesenchymal transition that have undergone BMP2/RUNX2 signaling pathway induction
... human breast cancer cell lines T47D and MDA-MD-231 were cultured in RPMI 1640 (Invitrogen, Carlsbad, CA, USA), and the human breast cancer cell line MCF-7 and the osteosarcoma cell line MG-63 ...
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Topographic expression of the Hippo transducers TAZ and YAP in triple-negative breast cancer treated with neoadjuvant chemotherapy
... 26], cancer stem cell (CSC) self-renewal [4, 5], luminal to basal lineage switch [27], and distant dissemination [5, ...the cancer-associated fibroblast (CAF) phenotype [8], and metastatization [32, ...
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USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2
... some cancer types, such as lung and prostate cancer [7, ...prostate cancer cell line LNCaP after transfection with let-7a mimics or let-7a ...LNCaP cells with let-7a mimics while decreased ...
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Original Article Bmi-1 regulates epithelial-to-mesenchymal transition to promote migration and invasion of breast cancer cells
... in breast cancer cells that promotes EMT and cellular ...in breast cancer, par- ticularly in advanced ...in breast cancer ...of breast cancer cells ...
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Approaches to isolation and molecular characterization of disseminated tumor cells
... Much progress has been made recently towards genomic characterization of CTCs [69]. Despite a longer history of active study for DTCs as compared to CTCs, there are relatively few genomic studies of DTCs to date [69]. ...
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Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2
... EMT, cancer cells undergo morphological changes, such as cell-cell junction dissolution, loss of apical-basolateral cell polarity, and acquisition of mesen- chymal marker expression ...in breast ...
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