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Sleeping Beauty

Quantum Sleeping Beauty

Quantum Sleeping Beauty

... the Sleeping Beauty case, this means we can treat the situation as if Sleeping Beauty is told that when the coin comes up tails, she will be woken up either on Monday or on Tuesday, with equal ...

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Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers

Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers

... Background: The transposon-based gene delivery technique is emerging as a method of choice for gene therapy. The Sleeping Beauty (SB) system has become one of the most favored methods, because of its ...

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Insertional Mutagenesis by a Hybrid PiggyBac and Sleeping Beauty Transposon in the Rat

Insertional Mutagenesis by a Hybrid PiggyBac and Sleeping Beauty Transposon in the Rat

... lesion. Sleeping Beauty transposase inserts Sleeping Beauty transposons into highly abundant TA sequences in the genome (Ivics et ...than Sleeping Beauty, Tol2, and Mos1 in ...

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The Sleeping Beauty Transposable Element:  Evolution, Regulation and Genetic Applications

The Sleeping Beauty Transposable Element: Evolution, Regulation and Genetic Applications

... Members of the Tc1/mariner superfamily of transposable elements isolated from vertebrate species are inactive due to the accumulation of mutations. A representative of a subfamily of fish elements estimated to be last ...

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Remobilization of Sleeping Beauty transposons in the germline of Xenopus tropicalis

Remobilization of Sleeping Beauty transposons in the germline of Xenopus tropicalis

... Figure 4 Excision and re-integration of SB transposons in the progeny of double-transgenic hopper frogs. (a) GFP expression in sibling tadpoles derived from the outcross of an 8F hopper frog. Tadpoles 1 and 2 are ...

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High-performance gene expression and knockout tools using sleeping beauty transposon system

High-performance gene expression and knockout tools using sleeping beauty transposon system

... live cells. FBW7 is an F-box protein that recruits sub- strates for the SCF FBW7 E3 ubiquitin ligase. SCF FBW7 de- grades several well-known oncoproteins, including Cyclin E [18], Notch [19], c-Jun [20] and c-Myc [21]. ...

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Manipulating the sleeping beauty mutase operon for the production of 1-propanol in engineered Escherichia coli

Manipulating the sleeping beauty mutase operon for the production of 1-propanol in engineered Escherichia coli

... the sleeping beauty mutase (Sbm) operon in ...Sbm; sleeping beauty mutase), which catalyzes the isomerization of succinyl-CoA to L-methylmalonyl-CoA; (2) ygfG encoding a methylmalonyl-CoA ...

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Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen

Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen

... the Sleeping Beauty (SB) transposon, several studies produced PDA and discovered a number of common insertion sites (CIS) and associated genes that are recurrently mutated at high ...

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Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance

Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance

... HIV/AIDS continues to be major public health threat with new infections on the rise. Current therapies do not com- pletely cure the disease and there is no effective vaccine available [1,2]. A potentially rewarding ...

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Nanocapsule delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice

Nanocapsule delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice

... encapsulated Sleeping Beauty transposon expressing the B domain–deleted canine FVIII in cis with Sleeping Beauty transposase in hyaluronan nanocapsules and injected them intravenously into ...

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The Sleeping Beauty Problem: What about Monday?

The Sleeping Beauty Problem: What about Monday?

... the sleeping beauty problem can give us reason to reject PP it would have to be by showing that any reasonable solution to the problem is such that conditionalizing on some admissible evidence E ...the ...

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Sleeping Beauty transposon integrates into non-TA dinucleotides

Sleeping Beauty transposon integrates into non-TA dinucleotides

... The Sleeping Beauty transposon (SB) is a DNA transposon of the Tc1/mariner family, which was constructed from a consensus transposable element sequence in the genome of the Salmonid subfamily of fish ...

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Sleeping Beauty on Monty Hall

Sleeping Beauty on Monty Hall

... notorious Sleeping Beauty ...of Sleeping Beauty, during which she will be asked about the outcome of the coin toss that determined earlier how many times she is awakened and asked, are ...

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Self-locating belief and the Sleeping Beauty problem

Self-locating belief and the Sleeping Beauty problem

... Let P be the credence function you ought to have upon first awakening. Upon first awakening, you are certain of the following: you are in predicament H 1 if and only if the outcome of the coin toss is Heads. Therefore, ...

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Awakening the sleeping beauty: Estonian 1939 recordings

Awakening the sleeping beauty: Estonian 1939 recordings

... The project “Estonian Sound Recording 1939” (ESR 1939) is an attempt to awaken a sleeping beauty. In May 1939, an ambitious series of recording sessions took place in Tallinn, lasting about one month. The ...

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Phase I trials using Sleeping Beauty to generate CD19 specific CAR T cells

Phase I trials using Sleeping Beauty to generate CD19 specific CAR T cells

... Twenty-six patients with advanced non-Hodgkin lymphoma and acute lymphoblastic leukemia safely underwent hematopoietic stem cell transplantation HSCT and infusion of CAR T cells as adjuv[r] ...

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Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase

Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase

... Escherichia coli is a robust microorganism. The heterolo- gous production of organic acids and alcohols by E. coli has proven to be a suitable option as evidenced by the commer- cial success of succinate production [9] ...

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“Sleeping Beauty” Unleashed: Harmonizing a Consolidated European Security and Defense Union  ZEI Discussion Paper C 248/2018

“Sleeping Beauty” Unleashed: Harmonizing a Consolidated European Security and Defense Union ZEI Discussion Paper C 248/2018

... It also urges autonomy for member states to act in accordance with their state sovereignty, a more credible defense industry with greater effectiveness, efficiency and trust between memb[r] ...

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Sleeping Beauty, Mice, & Dogs: Cell Death in Narcolepsy

Sleeping Beauty, Mice, & Dogs: Cell Death in Narcolepsy

... Humans descend into REM after an hour or so of sleeping. In the drowsy period, also known as Stage I sleep, the frequency spectrum of the electroencephalogram (EEG) is shifted to lower numbers, and the amplitude ...

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Sustainable development education in Scottish schools: the sleeping beauty syndrome

Sustainable development education in Scottish schools: the sleeping beauty syndrome

... Summary The emergence of Learning for life, then, provided a clear, forward thinking and pedagogically appropriate curriculum proposal for the field in the 1990s, which might have placed[r] ...

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