SMAD2/3 signaling
<p>MDM2 promotes epithelial–mesenchymal transition through activation of Smad2/3 signaling pathway in lung adenocarcinoma</p>
... (Smad) signaling in MDM2-mediated EMT in lung adenocarcinoma ...the Smad2/3 signaling pathway, Smad2 and Smad3 were also silenced by siRNA in H1975 ...of Smad2/3 was ...
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Silencing Trim59 inhibits invasion/migration and epithelial-to-mesenchymal transition via TGF-β/Smad2/3 signaling pathway in bladder cancer cells
... Abstract: The evolutionarily conserved genes that encode the tripartite motif (TRIM) protein family are involved in various biological processes, including cellular immunity, inflammatory reaction, antiviral activity, ...
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Original Article Increased Tbx1 expression may play a role via TGFβ-Smad2/3 signaling pathway in acute kidney injury induced by gentamicin
... downstream signaling molecules including p-Smad ...TGFβ-Smad2/3 signaling pathway in the pathogenesis of renal injury and fibrosis is well recognized [3, 15, ...24]. ...
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Lyn regulates epithelial–mesenchymal transition in CS-exposed model through Smad2/3 signaling
... Results: The gain of mesenchymal markers vimentin and α -SMA with a concomitant loss of E-cadherin was observed in both in vivo and in vitro studies. Meanwhile, cigarette smoking extracts (CSE) induced EMT in 16HBE cells ...
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Fibroblast specific TGF β–Smad2/3 signaling underlies cardiac fibrosis
... TGF-β signaling mobilizes Smad2 and Smad3 transcription factors that control fibrosis by promoting gene ...TGF-β–Smad2/3 signaling in fibroblast-mediated cardiac fibrosis has not been ...
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<p>Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-β/Smad2/3 signaling pathway</p>
... 2, 3, 5, 8), which enter into nucleus together with Smad4 and leading to the transcription of downstream .../Smads signaling in many human .../Smad2/3 signaling pathway may be an ...
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MFAP2 promotes epithelial–mesenchymal transition in gastric cancer cells by activating TGF-β/SMAD2/3 signaling pathway
... In the current study, we report that MFAP2 is overex- pressed in human GC tissues and its overexpression cor- relates with tumor invasion depth, lymph node metastasis, distant metastasis, and tumor node metastasis (TNM) ...
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Inflammatory conditions partly impair the mechanically mediated activation of Smad2/3 signaling in articular cartilage
... Joint trauma is a well-established risk for the develop- ment of OA and this is often attributed to the fact that after joint injury the cartilage is overloaded in the pres- ence of inflammatory mediators. However, in ...
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Pentoxifylline Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling
... Anti-Thy1 glomerulonephritis is a rat nephritis model closely simulating human mesangial proliferative glomerulonephritis. It af- fects primarily the mesangium, yet displays substantial proteinuria during the course. ...
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Activin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signaling
... (reverse); SMAD2, 5′- GCC TTT ACA GCT TCT CTG AAC AA-3′ (forward) and 5′-ATG TGG CAA TCC TTT TCG AT-3′ (reverse); SMAD3, 5′-CCC CAG CAC ATA ATA ACT TGG-3′ (forward) and 5′-AGG AGA TGG AGC ACC ...
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A novel Nodal enhancer dependent on pluripotency factors and Smad2/3 signaling conditions a regulatory switch during epiblast maturation
... Figure 3. HBE enhancer activity depends on Oct4. (A, B, D–F) Luciferase reporter assays in ESCs using either a minimal (E1b) promoter or the endogenous sequence (NIS). (A) HBE activity before and after Nanog ...
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Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate
... With respect to GDF11, previous work showed that it acts directly on INPs both to decrease their rate of cell division and increase their probability of differentiating into ORNs (Wu et al., 2003; Lander et al., 2009). ...
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EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells
... of Smad2/3 in EGF-induced Snail gene expression, MCF-7 cells were pretreated with two known inhibitors (PD169316 and SB203580) of Smad2 phosphorylation [25, ...ERK1/2-Smad2/3 ...
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<p>Growth and differentiation factor 15 regulates PD-L1 expression in glioblastoma</p>
... Smad-dependent Smad2/3 signaling and Smad-independent signaling such as ERK1/2 and ...β signaling pathways to explore the molecular mechanism by which GDF15 regulates PD-L1 expression ...
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TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A
... resulting SMAD2/3 ...where SMAD2/3 signaling comes into play) to SMAD2 and SMAD3 (siSMAD2/3), and then differentiated in the absence or presence of IL- 1 a and TNF- a .... ...
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Inhibition of myocyte-specific enhancer factor 2A improved diabetic cardiac fibrosis partially by regulating endothelial-to- mesenchymal transition
... Myocyte enhancer factor 2A (MEF2A) belongs to a family of four closely related transcription factors (MEF2A, -B, -C, and -D) that are conserved from yeast to humans [8]. MEF2A functions during fetal development of the ...
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Activation of Smad2 but not Smad3 is required to mediate TGF β signaling during axolotl limb regeneration
... β signaling is impaired with SB-431542, the wound epithelium fails to form in Xenopus and regeneration does not occur (Ho and Whitman, ...of Smad2 is Activin rather than TGF- β 1 ...the Smad2 ...
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Sjögren’s syndrome associated microRNAs in CD14+ monocytes unveils targeted TGFβ signaling
... High-throughput miRNA target validation strategies are currently limited. Therefore, multiple miRNA target pre- diction algorithms and validated miRNA-target inter- action databases were incorporated to identify ...
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Endothelial to mesenchymal transition drives atherosclerosis progression
... Atherosclerosis is a progressive disorder initiated by biomechanical forces in areas of the vascular tree subjected to disturbed blood flow and a number of systemic factors, including hyperlipidemia, smok- ing, and ...
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Sildenafil May Have an Inhibition Effect on The TGFβ1- Smad2/3 Pathway in PAH Rats
... England), Smad2 (diluted 1:1000; Abcam, England), Smad3 (diluted 1:5000; Abcam, England), P-Smad2 (diluted 1:300;Abcam,England),P-Smad3(dilut- ed 1:300; Abcam, England) and rabbit anti-GAPDH (diluted ...
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