small ubiquitin-like modifier
Small ubiquitin like modifier protein, SUMO enables plants to control growth independently of the phytohormone gibberellin
... the ubiquitin- mediated proteasomal degradation of DELLAs and consequently growth ...the Small Ubiquitin-like Modifier (SUMO) protein, the extent of conjugation increasing during ...
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Regulation of Vaccinia Virus E3 Protein by Small Ubiquitin-Like Modifier Proteins
... the small ubiquitin-like modifier (SUMO) protein, and SUMOylation seems to facilitate viral infections of the host cells ...of ubiquitin- like proteins, which shares about 18% ...
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Matic, Ivan (2009): Proteomics of SUMO, the small ubiquitin-like modifier. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... The Small ubiquitin-like modifier (SUMO) is the Ubl that seems to modify the largest pool of proteins and it shares approximately 20% sequence identity with ubiquitin (Johnson, ...
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Stability of small ubiquitin like modifier (SUMO) proteases OVERLY TOLERANT TO SALT1 and 2 modulates salicylic acid signalling and SUMO1/2 conjugation in Arabidopsis thaliana
... Small ubiquitin-like modifier proteases 1 and 2 (SUMO1/2) have been linked to the regulation of salicylic acid (SA)- mediated defence signalling in Arabidopsis ...
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Small ubiquitin-like modifier 1 modification of pyruvate kinase M2 promotes aerobic glycolysis and cell proliferation in A549 human lung cancer cells
... 0.73±0.11, P=0.032). (D) A549 cells were transfected with HA-tagged PKM2-WT or K336R. After 24 h of transfection, the cells were replated into appropriate plates for analysis of basal oxygen consumption rate by a ...
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An investigation into the role and mechanism of action of small ubiquitin like modifier interacting motifs in Arabidopsis thaliana proteins
... predict SUMO sites so their model, which did not utilise variable selection to an appreciable degree, was a useful benchmark to compare with. PCA was used to reduce the multitude of amino acid indices into a small ...
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Myositis-specific autoantibodies: detection and clinical associations
... to ubiquitin, and, like ubiquitin, can be post-translationally conjugated to other proteins by a similar ...the small ubiquitin-like modifier activating enzyme (SAE), ...
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SUMO suppresses the activity of the jasmonic acid receptor CORONATINE INSENSITIVE 1
... Stability of small ubiquitin-like modifier SUMO proteases OVERLY TOLERANT TO SALT1 and -2 modulates salicylic acid signalling and SUMO1/2 conjugation in Arabidopsis thaliana.. Pubmed: Au[r] ...
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Improving Soluble Expression of Curcin-Transferrin Receptor-binding Peptide Fusion Protein with Glutathione Transferase-Small Ubiquitin-related Modifier System
... with a purity of more than 95%. The curcin-TfRBP9 fusion protein had significant proliferation inhibitory effects on the lung cancer A549 cells that over-expressed transferrin receptors, and it had lower inhibitory ...
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Lin, Sean (2017): Role of the ubiquitin-like protein Urm1 as a protein modifier. Dissertation, LMU München: Fakultät für Biologie
... by small molecules but by entire proteins belonging to the ubiquitin family of ...modifiers. Ubiquitin-like proteins (UBLs) like ubiquitin, Smt3 (SUMO), Atg8, Rub1 (NEDD8), Hub1, ...
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The pupylation pathway and its role in mycobacteria
... effects like changes in protein conformation or stability, regulation of enzymatic activities to the determination of subcellular ...of small- protein modifiers such as ubiquitin was considered a ...
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<p>Ubiquitin-Fold Modifier-1 Participates in the Diabetic Inflammatory Response by Regulating NF-κB p65 Nuclear Translocation and the Ubiquitination and Degradation of IκBα</p>
... 12 Ubiquitin-fold modi fi er-1 (Ufm1) is a recently identi fi ed ...as small ubiquitin-like modi fi ers (SUMOs) and the ubiqui- tin-like protein ...
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Post-translational modification of Parkin and its research progress in cancer
... UBL: ubiquitin‑like domain; UPS: ubiquitin–proteasome system; SP22: 22‑kilodal‑ ton glycosylated form of α‑synuclein; PINK1: PTEN‑induced kinase 1; p‑Ub: phospho‑ubiquitination; BNIP3: Bcl‑2 and ...
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Recombinant production of self-assembling β-structured peptides using SUMO as a fusion partner.
... In the present study, we have used SUMO small ubiquitin-related modifier protein as a fusion partner for various self-assembling P11-peptides to address the question, can high yields of [r] ...
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Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity
... with ubiquitin metabolism that are synthetically lethal with PARP ...the ubiquitin-metabolism, the proteasome system and genes encoding zinc-finger proteins ...
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Characterization of the Interaction between the Parkin Ubiquitin-like domain and Ataxin-3 Ubiquitin Interacting Domains
... would like to thank all of those who helped me persevere throughout my graduate career at Western ...would like to thank Brian Dempsey for teaching me all the lab basics, for giving me guidance throughout ...
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Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin conjugating enzymes, ubiquitin activating enzymes, and ubiquitin like proteins
... C. elegans UBCs occurs in branch XVIII, corresponding to yeast Ubc6p. Ubc6p has a transmembrane domain in its carboxy-terminal extension that anchors the protein in the membranes of the endoplasmic reticulum (ER). The ...
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Progress in the Discovery of Small Molecule Modulators of DeSUMOylation
... responses, like the endoplasmic reticulum (ER) stress response, viral infections, nutrient response, and especially, the DNA damage response (Enserink, ...2015). Ubiquitin–SUMO crosstalk occurs extensively ...
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Ubiquitin crosstalk connecting cellular processes
... the ubiquitin-proteasome system (UPS) is essential for the survival of eukaryotic ...pathologies, like cancer, immunological disorders, inflammation and neu- rodegenerative diseases ...disturbed ...
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Structure and catalytic regulatory function of ubiquitin specific protease 11 N terminal and ubiquitin like domains
... to ubiquitin, but ubiquitin is still a relatively close structural neighbor, despite poor sequence ...additional ubiquitin binding domains, 3 we also investigated ubiquitin binding to the ...
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