SMC proliferation
Multidrug resistance associated protein 4 regulates cAMP dependent signaling pathways and controls human and rat SMC proliferation
... on SMC proliferation have been well ...during proliferation of isolated human coronary artery SMCs and following injury of rat carotid arteries in ...block proliferation and to prevent ...
12
Knockout of the murine ortholog to the human 9p21 coronary artery disease locus leads to SMC proliferation, vascular calcification, and advanced atherosclerosis
... lesion that was infiltrated by macrophages and had a thin fibrous cap. A ruptured plaque (PR) was defined by the presence of an acute luminal thrombus connected to a lipid-rich necrotic core through a disruption of a ...
19
Pathobiology of pulmonary arterial hypertension: understanding the roads less travelled
... Although the majority of patients with HPAH have heterozygous mutations in the BMPR2 gene, the penetrance of BMPR2 mutations is only 14–42%, indicating that other factors are involved in the pathogenesis of PAH [25]. ...
11
Sequence independent inhibition of in vitro vascular smooth muscle cell proliferation, migration, and in vivo neointimal formation by phosphorothioate oligodeoxynucleotides
... their SMC anti- proliferative ...the SMC antipro- liferative effects of the PS oligos and the recent demonstration of nonantisense, non–sequence-specific effects of the PS oli- gos, we hypothesized that the ...
9
Fibronectin glycation increases IGF-I induced proliferation of human aortic smooth muscle cells
... on SMC proliferation, cells were seeded at 2 × 10 4 cells/cm 2 into 96-well plates coated with either FN or AGE-FN and were cultured in medium supple- mented with 10% FCS until ...on SMC ...
9
Myeloperoxidase-oxidized high density lipoprotein impairs atherosclerotic plaque stability by inhibiting smooth muscle cell migration
... Given that MPO is a hallmark of unstable atheroscler- otic plaque and acute coronary events [11–14] and re- cent reports show that HDL is associated with MPO in ACS patients [17–19], our findings demonstrating that ...
11
Cyclosporine induced synthesis of endothelin by cultured human endothelial cells
... Endothelin (ET), a peptide synthesized by endothelial cells (EC), causes a decreased renal blood flow and glomerular filtration rate and an increased mean arterial pressure when infused in animals. In tissue culture, ET ...
6
Adenovirus-mediated Gene Transfer of cGMP-dependent Protein Kinase Increases the Sensitivity of Cultured Vascular Smooth Muscle Cells to the Antiproliferative and Pro-apoptotic Effects of Nitric Oxide/cGMP
... vascular SMC are passaged in ...cell proliferation at day 5 by ...vascular SMC can alter the sensitivity of these cells to NO and ...vascular SMC proliferation and apoptosis by NO and ...
11
Smooth muscle cell–specific fibronectin EDA mediates phenotypic switching and neointimal hyperplasia
... A particular strength of our study is the observation that Fn-EDA is expressed in the neointima of stented human coronary artery specimens and targeting Fn-EDA with a specific inhibitor suppressed the synthetic phenotype ...
21
Mouse Cytomegalovirus M33 Is Necessary and Sufficient in Virus-Induced Vascular Smooth Muscle Cell Migration
... MCMV-induced SMC migration. SMC migration from the media into the neointimal space is a hallmark of vascular lesion formation, suggesting that patho- gen-mediated acceleration of vascular disease involves ...
8
Fish oil supplementation reverses the effect of cholesterol on apoptotic gene expression in smooth muscle cells
... of SMC proliferation [46], and cultured SMC from atherosclerotic plaque have shown an over- expression of c-myc with respect to control SMC ...causes SMC to proliferate but ...
9
Regulation of human aortic endothelial cell derived mesenchymal growth factors by allogeneic lymphocytes in vitro A potential mechanism for cardiac allograft vasculopathy
... proliferation; and (c) alteration of HAEC mRNA levels for a panel of known SMC growth factors. Co-culture conditioned medium increased SMC proliferation, compared to medium conditioned by ...
10
Long term biological response of injured rat carotid artery seeded with smooth muscle cells expressing retrovirally introduced human genes
... proliferation and intimal thickening in balloon-injured Fischer 344 rat carotid arteries seeded with SMCs stained with the fluorescent marker 1,1'-dioctadecyl-3,3,3',3'-tetramethylindo- carbocyanine perchlorate ...
9
Adenovirus-Mediated Expression of a Ribozyme to c-mybmRNA Inhibits Smooth Muscle Cell Proliferation and Neointima Formation In Vivo
... of SMC proliferation should result in a reduction in c-myb mRNA levels relative to those seen in uninfected or control virus-infected ...of SMC proliferation by infection with Ad/U6⫹27Rz was ...
7
Conformable Fractional Order Sliding Mode Control for a Class of Fractional Order Chaotic Systems
... terminal SMC was represented to control a class of nonlinear systems with ...FO SMC. In [8], a FO SMC based on a nonlinear disturbance observer was developed for a class of FO systems in the presence ...
12
Loss of Caenorhabditis elegans BRCA1 Promotes Genome Stability During Replication in smc-5 Mutants
... dysfunctional SMC-5/6 suggests that the maintenance of familial BRCA1 carrier mutations might confer selective advantages under certain conditions of genotoxic ...
28
Enhancement of Power Quality with Fuzzy Based Dstatcom Supported Induction Generator
... the SMC which suppresses undershoots and overshoots in the DC-link ...of SMC for regulating the DC link voltage of DSTATCOM offers various advantages such as reduction in number of sensors for estimating ...
7
NOS-2 participates in the behavioral effects of ethanol withdrawal in zebrafish
... Adult zebrafish were treated with 1% EtOH for 20 min per day for 8 days, injected with the nitric oxide synthase 2 (NOS-2) inhibitor aminoguanidine (50 mg/kg), and allowed to experien[r] ...
8
Implementation of SMC for BLDC Motor Drive
... In this case, there is significant overshoot in PI controller and also the time required to reach the reference speed of PI controller is more than that of the SMC controller. There is also variation in the ...
6
Robust control system for Spacecraft Motion Trajectory
... A flying spacecraft formation controller is designed in [3] using a sliding mode control (SMC) scheme with an adaptive gain. The main benefit of the SMC is the robust stability of the cl[r] ...
15