smooth muscle α-actin
Smooth muscle α-actin is a direct target of PLZF: effects on the cytoskeleton and on susceptibility to oncogenic transformation
... Although smooth muscle α-actin is present predomi- nantly in vascular smooth muscle cells, smooth muscle α-actin is also expressed in CEF [23], which ...
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Endothelial to mesenchymal transition drives atherosclerosis progression
... encodes smooth muscle α-actin, and NOTCH3) (Figure 1D) and mesenchy- mal markers (N-cadherin, fibronectin 1, and collagen 1A) (Figure ...
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IL-32γ attenuates airway fibrosis by modulating the integrin-FAK signaling pathway in fibroblasts
... and α -smooth muscle actin ( α -SMA) was examined and the transforming growth factor (TGF)- β -related signaling pathways was evaluated in activated human lung fibroblasts (MRC-5 cells) ...
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Origin of neointimal endothelium and α actin–positive smooth muscle cells in transplant arteriosclerosis
... of α -actin–positive VSM cells (Figures 1c and 3f), neointimal lesions can also contain an appreciable number of recipient-derived infiltrating leukocytes, especially macrophages ...
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Immunohistochemical Evaluation of Stromal Myofibroblasts by Alpha Smooth Muscle Actin in Potentially Malignant and Malignant Lesions of the Oral Cavity: A Retrospective study
... for α-SMA expression ...of α- SMA expression were noted in severe grades of dysplasia and between epithelial dysplasia and squamous cell ...of α-SMA expression for MF proliferation can be used as a ...
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Myofibroblast expression in airways and alveoli is affected by smoking and COPD
... alpha-smooth muscle actin ( α -SMA) positive, spindle-shaped mesenchymal ...lar α-SMA filaments and extracellular Fn bundles, dilated rough endoplasmic reticulum (rER) and adherens-type ...
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PAX7 is required for patterning the esophageal musculature
... anti-sarcomeric actin (5C5; 1:1000; Sigma-Aldrich), rabbit anti–α-smooth muscle actin (1:200; Abcam), rabbit anti-MyoD (1:500; Santa Cruz Biotechnology, ...
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Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway
... I, α-smooth muscle actin (α-SMA), fibronectin, and con- nective tissue growth factor (CTGF), compared with eutopic endometrial MSCs from women with or without endometriosis and that ...
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Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: an observational study
... angiopoietin; α -SMA: α smooth muscle actin; BV/mm 2 : number of vessels per square millimetre; CCP: cyclic citrullinated peptide; CRP: C-reactive protein; DAS: disease activity score; ...
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Anti-fibrogenic effect of PPAR-γ agonists in human intestinal myofibroblasts
... monoclonal α-smooth muscle actin (α-SMA) antibody (A2547, Sigma-Aldrich), rabbit polyclonal fi- bronectin (FN) antibody (ab2413, Abcam, Cambridge, MA), rabbit polyclonal phospho-Akt ...
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The inhibitory effect of small interference RNA protein kinase C-alpha on the experimental proliferative vitreoretinopathy induced by dispase in mice
... and α-smooth muscle actin were increasing in the retina with the decreasing concentration of siRNA-PKCα, indicating that intraocular siRNA-PKCα can partly inhibit changes of markers for glia ...
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Inhibition of airway remodeling in IL 5–deficient mice
... peribronchial smooth muscle (thickness of peribronchial smooth muscle layer, α-smooth muscle actin immunostaining) compared with WT mice challenged with ...lial ...
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Human induced pluripotent stem cell–derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis
... genes α–smooth muscle actin (αSMA), CollagenIα1, and tissue inhibitor of metalloproteinases–1 (TIMP-1) in HSCs primed with the profibrogenic agent transforming growth factor–β (TGF-β) and ...
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Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts
... of α -smooth muscle actin ( α -SMA), fibroblast specific protein-1 (S100A4), COL-1, and FN were investigated by western blotting and quantitative real-time ...
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Specialized mouse embryonic stem cells for studying vascular development
... cardiac muscle (dotted circle) with clearly defined sarcomere ...and α-SMA RFP+ cells interacting with each ...by α-SMA RFP+ cells and strongly Tie-2 GFP+ cells that form venule-like ...of ...
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Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury
... vascular smooth muscle cells (VSMCs) contributes to the development and progression of vascular lesions, little is known regarding the molecular mechanisms of phenotypic modulation in ...for smooth ...
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FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis
... of α-smooth muscle actin (α-SMA) in phLF led to inhibition of migration without affecting the FAK signaling pathway ...in actin dynamics may underlie the observed inhibition of ...
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Original Article All-trans retinoic acid in combination with collagen IV induces the differentiation of mouse embryonic stem cells into smooth muscle cells
... against α-SMA antibody (#ab7817; 1:500; Abcam, Cambridge, USA), SM-MHC antibody (#ab683; 1:1000; Abcam, Cambridge, USA) and β-actin antibody (#ab- 8226; 1:1000; Abcam, Cambridge, USA) at 37°C for 2 ...
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Clonorchis sinensis lysophospholipase A upregulates IL 25 expression in macrophages as a potential pathway to liver fibrosis
... against α-smooth muscle actin (α-SMA) (Proteintech, Chicago, USA), IL-25 (R&D, Minneap- olis, USA), total ERK1/2, phospho-ERK1/2, total AKT, phospho-AKT, phospho-B-Raf (Cell ...
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Matrisome analysis of intrahepatic cholangiocarcinoma unveils a peculiar cancer-associated extracellular matrix structure
... many α-smooth muscle actin (α-SMA)- positive cancer associated fibroblasts (CAFs) which in turn lead to an increased of an aberrant extracellular matrix (ECM) production [6, ...
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