Sodium (Na+) channels
Sodium channels in cardiac myocytes
... individual channels switching between two modes of gating (fast gating or slow ...of sodium channels could be responsible for slowly inactiviting sodium currents (Moorman et ...chattering ...
180
Sodium channels and mammalian sensory mechanotransduction
... these sodium channels does not affect the cellular transduction of mechanical stimuli, which suggests that the two types of channels operate independently of each other (also see ...
12
Inherited disorders of voltage gated sodium channels
... The sodium channelopathies were among the first recognized ion channel diseases and continue to attract widespread clinical and scientific ...gated sodium channels and provided new insights into the ...
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Molecular and functional characterization of voltage-gated sodium channels in human sperm
... each Na v channel in all ...for Na v 1.1, Na v 1.3 and Na v ...the Na v 1.6 one. Preincubation of the Na v ...all Na v proteins assayed, unspecific binding was not ...
9
Voltage-gated sodium channels and metastatic disease
... developing metastasis. 30 A similar pattern has been observed in prostate cancer cells, where VGSC expression increases in line with metastatic potential in the LNCaP progression model. 35 In agreement with this, the ...
33
Salt, sodium channels, and SGK1
... the internalization of ENaCs from the plasma membrane. In this issue of the JCI, Zhang et al. demonstrate that SGK1 enhances transcription of the α sub- unit of ENaC by preventing histone methylation, providing an ...
5
Energetics of ion competition in the DEKA selectivity filter of neuronal sodium channels
... Figure 7. (Color online) The various terms of the free energy advantage for [Ca 2+ ]=10 mM and [Na + ]=50 mM. Top and bottom panels show the results for ² pr = 10 and 80, respectively. Left panels show the EX ...
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Ammonia independent sodium uptake mediated by Na+ channels and NHEs in the freshwater ribbon leech Nephelopsis obscura
... channel-like genes in the leech Helobdella robusta genome (DOE Joint Genome Institute). PCR products of the predicted size were purified (E.Z.N.A. gel extraction kit, Bio-Tek, Winooski, VT, USA) and sequenced (Robarts ...
10
Lethal Sodium Channel Antagonist Natural Neurotoxin
... ion channels, signal transducers that provide a regulated path for the movement of inorganic ions such as Na+, K+, Ca2+, and Cl- across the plasma membrane in response to various ...In Na+ ...
10
Evolution of voltage gated Na+ channels
... Chen, Y. H., Dale, T. J., Romanos, M. A., Whitaker, W. R. J., Xie, X. M. and Clare, J. J. (2000). Cloning, distribution and functional analysis of the type III sodium channel from human brain. Eur. J. Neurosci. ...
10
Breakdown of accommodation in nerve: a possible role for persistent sodium current
... persistent sodium chan- nels are modeled as discrete ...transient sodium channels. Three discrete persistent and late sodium currents have been identified on the basis of inac- tivation ...
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Complex management of a patient with refractory primary erythromelalgia lacking a <em>SCN9A </em>mutation
... Abstract: A 41-year-old woman presented with burning and erythema in her extremities triggered by warmth and activity, which was relieved by applying ice. Extensive workup was consistent with adult-onset primary ...
5
The role of intracellular sodium (Na+) in the regulation of calcium (Ca2+) mediated signaling and toxicity
... the current-voltage (I/V) relationship in NMDAR sin- gle-channels recorded in cell-attached patches, which indicates that there is a cell-depolarization, but no change in single-channel conductance [30,77]. In ...
8
One Step Synthesis of Titanium Oxyhydroxy Fluoride Rods and Research on the Electrochemical Performance for Lithium ion Batteries and Sodium ion Batteries
... one-dimension channels for Li/Na intercalation/de-intercalation, the electrochemical performance of titanium oxyhydroxy-fluoride for both lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs) ...
7
Tumor necrosis factor α modulates sodium-activated potassium channel SLICK in rat dorsal horn neurons via p38 MAPK activation pathway
... neurons. Sodium-activated potassium (K Na ) channels are highly expressed particularly in the central nervous system; however, information about whether rat DH neurons express the SLICK channel ...
7
Current and emerging “at-site” pain medications: a review
... ion channels (sodium channels, T-type calcium channels, P2X receptors, TRP channels), peptide receptor antagonists, NGF and glial cell modulators to treat nociceptive, inflammatory, and ...
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Threshold electrotonus and ion channel dysfunction in motor neurone disease
... theories of aetiology, with excess glutamate as the cause. The drug riluzole, part of the benzothiazole family of compounds, is now licensed for use in patients with MND, as it has been shown to prolong survival in the ...
196
Role of Inositol 1, 4, 5-Triphosphate on Heart Rate in Isolated Heart Models of Wistar Rats
... nucleotide-gated) channels which produces an inward current called the funny ...calcium channels get activated and produce more ...the sodium calcium exchanger in forward mode and produces a ...
144
Effect of tolvaptan on renal water and sodium excretion and blood pressure during nitric oxide inhibition: a dose-response study in healthy subjects
... increased water transport from the tubular lumen to the intracellular space via the aquaporin2 water channels, lo- cated in the principal cells in the distal part of the neph- ron [28, 30]. Surprisingly, u-AQP2 ...
11
Kaufman_JSM_2016
... To set the scene, we start by summarising the generic electrostatics and Brownian dynamics model of calcium/sodium channels ( section 2 ) , including a short description of the Coulomb blockade model of ...
11