sodium taurocholate cotransporting polypeptide
A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide
... Although sodium taurocholate cotransporting polypeptide (NTCP) has recently been reported to be an es- sential host factor for HBV entry, there is a limited number of reports that identify new ...
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Unusual Features of Sodium Taurocholate Cotransporting Polypeptide as a Hepatitis B Virus Receptor
... identified sodium taurocholate cotransporting polypeptide (NTCP) as a binding partner for myristoylated preS1 peptide 2-48 (nomenclature based on genotype D) ...
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N-Linked Glycosylation Is Not Essential for Sodium Taurocholate Cotransporting Polypeptide To Mediate Hepatitis B Virus Infection In Vitro
... ABSTRACT Sodium taurocholate cotransporting polypeptide (NTCP) has been iden- tified as a hepatitis B virus (HBV) receptor, and its overexpression in HepG2 cell lines leads to efficient ...
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Hepatitis B Virus Infection of a Mouse Hepatic Cell Line Reconstituted with Human Sodium Taurocholate Cotransporting Polypeptide
... H epatitis B virus (HBV) is a hepatotropic, enveloped DNA vi- rus replicating via an RNA intermediate (1). Infections with HBV and coinfections with hepatitis delta virus (HDV), which uses the HBV envelope for ...
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A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species Specificity
... ABSTRACT Hepatitis B virus (HBV) and its hepadnavirus relatives infect a wide range of vertebrates, from fish to human. Hepadnaviruses and their hosts have a long history of acquiring adaptive mutations. However, there ...
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Viral Entry of Hepatitis B and D Viruses and Bile Salts Transportation Share Common Molecular Determinants on Sodium Taurocholate Cotransporting Polypeptide
... transporter sodium taurocholate cotransporting polypeptide (NTCP) is responsible for the majority of sodi- um-dependent bile salts uptake by ...blocks taurocholate uptake by the ...
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Modification of Three Amino Acids in Sodium Taurocholate Cotransporting Polypeptide Renders Mice Susceptible to Infection with Hepatitis D Virus In Vivo
... Sodium taurocholate cotransporting polypeptide (NTCP) was identified as a functional receptor for hepatitis D virus (HDV) and its helper hepatitis B virus ...
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Sodium Taurocholate Cotransporting Polypeptide Mediates Woolly Monkey Hepatitis B Virus Infection of Tupaia Hepatocytes
... that sodium taurocholate cotransporting polypeptide (NTCP; also known as SLC10A1 [solute carrier family 10 member 1]), a hepatic sodium/bile acid symporter presumed to span the cellular ...
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Molecular Determinants of Hepatitis B and D Virus Entry Restriction in Mouse Sodium Taurocholate Cotransporting Polypeptide
... genome. Sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for HBV and HDV, and amino acids 157 to 165 of NTCP are critical for viral entry and likely limit viral ...
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Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles
... Journal of Virology Downloaded from http://jvi.asm.org/ on November 6, 2019 by guest FIG 9 Sequence analysis of in vitro-generated virus-cell junction HBV DNA integration events in in si[r] ...
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Silencing Retinoid X Receptor Alpha Expression Enhances Early-Stage Hepatitis B Virus Infection In Cell Cultures
... the sodium taurocholate cotransporting polypeptide (NTCP) (HepG2-NTCP), HepaRG cells, and primary Tupaia hepatocytes (PTHs); reducing RXR ␣ expression significantly enhanced HBV infection in ...
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Original Article Regulation of hepatobiliary transporters during cholestasis may mediate the phenomenon of adaptation to cholestasis induced by rifampicin in rats
... Abstract: Background: It is known that antituberculosis drugs initially induce liver injury, and then the liver progres- sively adapts to the drug and mitigates the drug-induced liver injury. This study aimed to explore ...
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Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry
... the sodium-taurocholate cotransporting peptide (NTCP) as the HBV/HDV receptor [8], new NTCP-based culture systems have been developed to study HBV entry mecha- nisms ...
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INHERITED VARIATIONS IN THE ESTERASES OF TETRAHYMENA
... FIGURE 4.-Effect of eserine sulfate and sodium taurocholate on B (right) and C (left) groups of class I esterases with alpha naphthyl propionate as substrate... ESTERAS[r] ...
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MELPHALAN SPANLASTICS FOR ORAL ADMINISTRATION – FORMULATION AND DEVELOPMENT
... In the present study Span 60 and Span 40 are used as non ionic surfactants. Elasticity is attributed to the use of edge activators. Edge activators are the surfactant molecules that provide flexibility to the vesicles ...
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Sodium coupled Taurocholate Transport in the Proximal Convolution of the Rat Kidney In Vivo and In Vitro
... mmol/liter taurocholate in the presence of a Na o + > Na i + gradient was stimulated twofold compared with its uptake in the absence of a Na + ...of taurocholate was osmotically and temperature ...
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Hydrocortisone choleresis in the dog
... Hydrocortisone sodium succinate (Solu-Cortef; Upjohn Co., Kalamazoo, Mich.) has been found to induce choleresis in unanesthetized fasting dogs fitted with Thomas duodenal cannulae for direct quantitative ...
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Distribution and effects of PACAP, VIP, nitric oxide and GABA in the gut of the African clawed frog Xenopus laevis
... intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two neuropeptides belonging to the same gene superfamily, the ...
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DETERMINANTS OF THE FLOW AND COMPOSITION OF BILE IN THE UNANESTHETIZED DOG DURING CONSTANT INFUSIONS OF SODIUM TAUROCHOLATE
... CONCENTRATIONS OF CHLORIDE AND BIcARBOelectrolyte composition at any constant rate of NATE RELATED TO THE OUTPUT OF THE HYPOTHETICAL bile salt excretion are consistent with the view that[r] ...
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Emodin in Severe Acute Pancreatitis Treatment
... of sodium taurocholate, which was followed with emodin intervention; the study found that emodin could significantly decrease cytochrome C positive expres- sion and apoptosis of rat small intestine smooth ...
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