Solid lipid nanoparticles (SLNs)
<p>Primary Studies on Construction and Evaluation of Ion-Sensitive in situ Gel Loaded with Paeonol-Solid Lipid Nanoparticles for Intranasal Drug Delivery</p>
... paeonol-solid lipid nanoparticles-in situ gel (PAE-SLNs-ISG) drug delivery system based on nose-brain transport pathway, and to per- form related formulation optimization, preparation charac- ...
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Solid and liquid lipid-based binary solid lipid nanoparticles of diacerein: in vitro evaluation of sustained release, simultaneous loading of gold nanoparticles, and potential thermoresponsive behavior
... mixture-based solid lipid nanoparticles (SLNs) were prepared for delivery of diacerein, a novel disease-modifying osteoarthritis drug, with and without simultane- ously loaded gold ...
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Formation of ion pairing as an alternative to improve encapsulation and anticancer activity of all-trans retinoic acid loaded in solid lipid nanoparticles
... develop solid lipid nanoparticles (SLNs) loaded with retinoic acid (RA) to evaluate the influence of two lipophilic amines, stearylamine (SA) and benethamine (BA), and one hydrophilic, ...
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An update on the application of nano-scaled carriers against fluconazole-resistant Candida species: nanostructured lipid carriers or solid lipid nanoparticles?
... which lipid nanoparticle-based on solid matrix has gained considerable ...of lipid nanoparticles with solid matrix, namely solid lipid nanoparticles (SLNs) ...
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Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice
... into solid lipid nanoparticles ...BBR-loaded SLNs (BBR- SLNs) also have beneficial effects on hepatosteatosis is not ...on lipid metabolism in the liver using histological ...
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Development of solid lipid nanoparticles containing total flavonoid extract from<em> Dracocephalum moldavica</em> L. and their therapeutic effect against myocardial ischemia–reperfusion injury in rats
... TFDM-loaded solid lipid nanoparticles (TFDM-SLNs) and optimized the formulation of TFDM-SLNs using central composite design and response surface ...The nanoparticles of optimal ...
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Sesamol loaded solid lipid nanoparticles: a promising intervention for control of carbon tetrachloride induced hepatotoxicity
... into solid lipid nanoparticles ...(S- SLNs) to provide hepatoprotection post induction of liver ...ment. SLNs are an excellent colloidal carrier system [28,29] whose small size (<200 ...
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Piroxicam Loaded Solid Lipid Nanoparticles (SLNs): Potential for Topical Delivery
... suitable lipid nanocarriers for topical delivery of Piroxicam, known for its anti-inflammatory and anti-arthritic properties and to increase its therapeutic potential and residence time at the site of inflammation ...
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TARGETED DRUG DELIVERY THROUGH SOLID LIPID NANOPARTICLES AND ITS APPROACH: A REVIEW
... Solid lipid nanoparticles SLNs are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, research and clinical medicine as ...
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In vitro evaluation of chloroquine loaded and heparin surface functionalized solid lipid nanoparticles
... functionalized solid-lipid nanoparticles (SLNs) and evaluate the in vitro against chloroquine sen- sitive and chloroquine resistant ...
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TRANSDERMAL DELIVERY OF AZATHIOPRINE BY SOLID LIPID NANOPARTICLES: IN VITRO AND EX VIVO STUDIES
... prepare solid lipid nanoparticles (SLNs) of azathioprine to increase its permeability and to develop azathioprine loaded solid lipid nanoparticles (AZA SLNs) based ...
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Preparation and Characterization of Solid Lipid Nanoparticles Loaded with Cisplatin
... polymeric nanoparticles have been extensively studied to overcome above ...The solid lipid nanoparticles (SLNs), amongst other colloidal carriers, were found to be an ideal carrier for ...
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Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery
... and nanoparticles are reported as a potential formulation strategy for dermal ...therapeutic nanoparticles, especially in diseased and damaged skin and via appendageal routes such as the openings of hair ...
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A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: in vivo/in vitro examinations
... In the present investigation, a 12-day healing period was used, since preliminary investigations revealed that ulcer heal- ing is completed in 12 days. To determine the speed of wound healing, the ulcer area was measured ...
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Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer
... TOS-CDDP SLNs than from PTX/TOS-CDDP SLNs may be attributed to the presence of TAT-PEG-PE, in which PEG contributes for sustained ...from SLNs was greatly affected by the environ- mental ...
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Solid lipid nanoparticles modified with stearic acid–octaarginine for oral administration of insulin
... into SLNs and SA-R 8 . SA-R 8 - Ins-SLNs increased the uptake of the drug in the Caco-2 cell monolayer, which yielded a more potent hypoglycemic effect following duodenal ...and SLNs could be a ...
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Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications
... the lipid phase, at a stirring speed of 24,000 rpm with UltraTurrax ...Blank SLNs were prepared in a similar way, without the drug. Different lipid-to-drug ratios have been studied to evaluate their ...
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Cholesteryl oleate-loaded cationic solid lipid nanoparticles as carriers for efficient gene-silencing therapy
... A more relevant model for RNA interference (RNAi) applications is the siRNA-mediated targeting of endog- enous gene products rather than the transient transfection of plasmid-based genes. Therefore, we generated a ...
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Preparation and characterization of solid lipid nanoparticles containing cyclosporine by the emulsification-diffusion method
... drug, lipid, or other components may suffer chemical degradation due to the need of melting the lipid and/or to the increment of sample temperature during the ...obtain SLNs by the SEE method, thus, ...
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Modification of polyethylene glycol onto solid lipid nanoparticles encapsulating a novel chemotherapeutic agent (PK-L4) to enhance solubility for injection delivery
... Non-formulated PK-L4 demonstrated a burst effect, which is the rapid release of the drug into the blood caus- ing the concentration to quickly rise then briefly plateau. It causes an excessive drug concentration beyond ...
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