solid tumours
Treating High Risk Childhood Solid Tumours With Autologous Peripheral Blood Stem Cell Transplantation Early Experience In University Hospital Kuala Lumpur
... Treating High Risk Childhood Solid Tumours with Autologous Peripheral Blood Stem Cell Transplantation Early Experience in University Hospital, Kuala Lumpur Treating High Risk Childhood Solid Tu mours[.] ...
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PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours.
... advanced solid tumours with three parts: monotherapy dose-escalation (part A), monotherapy dose- expansion at maximum tolerated dose (MTD) (part B), and dose- escalation in combination with palliative ...
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The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours
... Although frequently described as discrete pathways, intracellular signalling cascades are probably more accurately considered as networks made up of multiple interactions between pathways. Physical interactions and ...
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Epigenetic treatment of solid tumours: a review of clinical trials
... with solid tumours than in leukaemia since cancer cells are more difficult to obtain, especially at multiple time ...in solid tumour tissues have been published and deserve spe- cial ...other ...
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Interplay between distribution of live cells and growth dynamics of solid tumours
... Experiments show that simple diffusion of nutrients and waste molecules is not sufficient to explain the typical multilayered structure of solid tumours, where an outer rim of proliferating cells surrounds ...
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Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo
... Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intrave- nous ...
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The Treatment of Solid Tumours with Complete Freund's Adjuvant
... The initial aim of this PhD project was to establish if CFA, when injected intratumourally, could improve survival and/or induce tumour regression in mouse models of solid tumours. To address this, survival ...
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Distribution of anti cancer drugs in solid tumours studied by MALDI MSI
... large solid tumours causing vessel occlusion and necrosis in the central part of the tumour and a viable rim around the periphery of tumour (Image adapted from Gridelli et al ...
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A systems-based mathematical modelling framework for investigating the effect of drugs on solid tumours
... The complexity of the tumour environment becomes even more relevant when one attempts to evaluate systematically the effects of anti-cancer drug on tumours. Differ- ent drugs such as doxorubicin and paclitaxel ...
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A novel method for isolation of histones from serum and its implications in therapeutics and prognosis of solid tumours
... Owing to the increased HDACs, use of HDAC inhibi- tors for treatment of cancer is considered to be a good treatment regime. But so far, the use of HDAC inhibitors had limited success in solid tumours ...
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Metabolic scaling in solid tumours
... of solid tumours contain both live and dead cells, and the fraction of live cells is exponentially smaller as the distance from the sources of nutrients and oxygen ...
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The L arginine NO pathway in the pathophysiology of blood vessels from solid tumours and rats in endotoxic shock
... a solid tumour (Baillie et ...prevascular solid tumour dormant, both in terms of growth and ...that solid tumours are dependent on angiogenesis to grow beyond a diameter of ~2-3mm (Folkman, ...
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MicroRNAs as Mediators of Resistance Mechanisms to Small-Molecule Tyrosine Kinase Inhibitors in Solid Tumours.
... 25 Over recent years, blood levels of circulating miRNAs from patients with solid tumours have been broadly investigated as potential predictors of response to targeted therapies [146]. Regarding the ...
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Does routine surveillance imaging after completing treatment for childhood solid tumours cause more harm than good? A systematic review and meta-analysis protocol
... The rationale for routine imaging for this group relies on a number of unproven assumptions [2]. The first of these is that this imaging will detect recurrence of can- cer before the child develops clinical symptoms of ...
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Targeted therapy with Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of solid tumours
... One study showed a reduction in tumours size in approximately 60% of women with BRCA- related metastatic breast cancer who received a Olaparib compared to 29% of patients receive chemotherapy. The median time to ...
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Multidrug resistance in paediatric solid tumours: identification and potential reversal
... is recognised that in general malignant tumours develop from a single clone, this tumour homogeneity does not persist as the disease progresses. Mutations occur with a frequency in the order of 1 in 10^ to 10^ ...
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Ex vivo chemosensitivity of melanoma and other solid tumours
... colonies are not seen. The culture conditions also affect the results obtained in several ways. Firstly the conditions do not always support the growth of certain tumour cells. Approximately one third of all ...
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Identification of a novel lytic peptide for the treatment of solid tumours
... of tumours suppressors and oncogenes by combining bio- informatic softwares provided by Expasy and the data base UniProtKB/ Swiss-Prot, which are both available online [51, ...
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Prospects for combined use of oncolytic viruses and CAR T-cells
... of solid tumours and, if so, for what duration ...established tumours may thereby be converted from a so-called “cold” to a “hot” state that is permissive for CAR T-cell entry, expansion and efficacy ...
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Prospective of 68Ga-Radiopharmaceutical Development
... Several cyclic monomeric and di- meric peptide ligands targeting chemokine receptor subtype CXCR4 which is up-regulated in human solid tumours as, for example mammary cancer, prostate [r] ...
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