soluble guanylate cyclase
Riociguat: a soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension
... (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine 3′,5′-monophosphate (cGMP) pathway has been shown to play an important role in cardiovascular physiology, especially in vasodilation and ...
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Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells
... Nitric oxide stimulates soluble guanylate cyclase (sGC) to convert GTP to the intracellular second messenger cGMP. In rat pulmonary artery smooth muscle cells, sGC is an obli- gate heterodimer ...
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Original Article Effects of methylene blue on the nitric oxide-soluble guanylate cyclase-cyclic guanylyl monophosphate pathway and cytokine levels in rats with sepsis
... Abstract: Background: Methylene blue (MB) inhibits the production of nitric oxide (NO) and cyclic guanylyl mono- phosphate (cGMP) and thus reverses septic hypotension, but the specific effects of MB on the ...
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Tissue Guanosine 3′,5′ Cyclic Monophosphate Levels and Soluble Guanylate Cyclase Activity: A POSITIVE CORRELATION DURING UNILATERAL CRYPTORCHIDISM IN THE RAT TESTIS
... of guanylate cyclase and tissue guanosine-3¢,5¢-cyclic monophosphate (cGMP) levels was investigated in rat testes after surgically induced unilateral ...homogenate guanylate cyclase activity ...
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Polymerase chain reaction localization of constitutive nitric oxide synthase and soluble guanylate cyclase messenger RNAs in microdissected rat nephron segments
... and soluble guanylate cyclase was carried out in the rat kidney, using an assay of reverse transcription and polymerase chain reaction in individual microdissected renal tubule segments along the ...
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Soluble guanylate cyclase stimulation: an emerging option in pulmonary hypertension therapy
... E ndothelial cell-derived nitric oxide (NO) acts on vascular smooth muscle cells in healthy subjects to induce vasodilation by increasing production of the secondary messen- ger cyclic guanosine monophosphate (cGMP) via ...
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Genetic modifiers of hypertension in soluble guanylate cyclase α1–deficient mice
... of soluble guanylate cyclase (sGCa 1 ), are prone to hypertension in some, but not all, mouse strains, suggesting that additional genetic factors contribute to the onset of ...
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A role for nitric oxide-mediated glandular hypofunction in a non-apoptotic model for Sjogren's syndrome
... of soluble guanylate cyclase by NO binding to the haeme moiety of the enzyme remains the best understood mechanism by which NO affects cellular function [11], it is far from the only ...
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Vol 18 (2019)
... Nitric oxide (NO)-soluble guanylate cyclase(sGC)-cGMP signalling is impaired in HF syndromes, which could predispose to vascular oxidative stress. Nitrates directly stimulate cGMP, but are limited by ...
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Nitric oxide amplifies interleukin 1 induced cyclooxygenase 2 expression in rat mesangial cells
... the soluble guanylate cyclase, methylene blue, reversed the stimulatory effect of NO do- nors on COX-2 mRNA expression; ( b ) the membrane-per- meable cGMP analogue, 8-Br-cGMP, mimicked the stimu- ...
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Vasodilator mechanisms of some novel and established nitric oxide 'donor' drugs and laser light on the isolated rat tail artery
... of soluble guanylate cyclase but it is now thought to be a heterodimer with Mr 82,000 and 70,000 subunits (Waldman & Murad, ...1987). Soluble guanylate cyclase purified from ...
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Comparative analysis of hemolymph proteome maps in diapausing and non-diapausing larvae of Sesamia nonagrioides
... kinase, soluble guanylate cyclase 89 Da, hypothetical protein KGM_22030, hypothetical protein Aae- L_AAEL004438 and hypothetical protein KGM_15508) were identified in the hemolymph of Lepidoptera for ...
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Chronic thromboembolic pulmonary hypertension: the evolving treatment landscape
... a soluble guanylate cyclase (sGC) stimulator that restores the nitric oxide–sGC–cyclic guanosine monophosphate pathway, which is impaired in the pathogenesis of PH ...Hypertension Soluble ...
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Role of adenylate cyclase, guanylate cyclase enzyme and phosphodiesterase isozyme modulation in animal models of epilepsy.
... adenylyl cyclase activators and ...of soluble guanylate cyclase ...adenylate cyclase inhibitors, soluble guanylate cyclase activator and inhibitors to evaluate the ...
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Natriuretic peptide binding sites in the gills of the pouched lamprey Geotria australis
... Adult pouched lampreys Geotrila australis Gray were trapped in eel traps on the Derwent River, Tasmania, as they were migrating upstream, following the completion of the marine trophic phase. They were held in running ...
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Calcium is the switch in the moonlighting dual function of the ligand-activated receptor kinase phytosulfokine receptor 1
... mechanisms regulating the overlapping dual functions of guanylate cyclase-embedded receptor kinases have remained elusive. Here we use PSKR1 as a representa- tive member of this novel class of receptor ...
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Atrial natriuretic peptide receptor subtype determination and biological actions of atrial natriuetic peptided in bovine cardiac muscle and hypertensive rat liver
... (guanylate cyclase coupled) and that the ANP-B receptors in SHR have, like WKY, a low affinity for des-ANP, but differ from WKY in possessing a higher affinity for ANP(5-25), The actions of ANP(5-25) in the ...
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Activation of Guanylate Cyclase-C With Heat-Stable Enterotoxin Fails to Potentiate Celecoxib-Induced Reduction in Colorectal Cancer Cell Growth in Vitro
... This study evaluated the use of heat-stable enterotoxin ST, a guanylate cyclase receptor type C GC-C agonist, in combination with celecoxib, a cyclooxygenase-2 COX-2 inhibitor, for the p[r] ...
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Lack of Guanylate Cyclase C results in increased mortality in mice following liver injury
... The family of particulate guanylate cyclases (GC) is known to play substantial roles in the function of a number of different organs. These membrane receptors include the natriuretic peptide receptors GC-A and GC- ...
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A Study of Functional Genomics for Unknown Proteins in Chlamydomonas reinhardtii
... RRM, RBD, or RNP domain EF-hand domain pair Adenylate and Guanylate cyclase catalytic domain Alpha/beta hydrolase family Helicase conserved C-terminal domain Myb-like DNA-binding domain [r] ...
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