Sonic Hedgehog signaling
The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling
... The BHC is a vestige of Rathke’s pouch (RP), which is formed from the ectodermal diverticulum of the ade- nohypophysis after its separation from the roof of the mouth. RP derives from the hypophyseal placode, which is ...
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Native V. Californicum Alkaloid Combinations Induce Differential Inhibition of Sonic Hedgehog Signaling
... difference between the alkaloid standard mixtures of the stem and root/rhizome samples and cyclopamine alone. This indicates the addition of veratramine, isorubijervine and muldamine enhance Hh inhibition. However, the ...
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Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus
... Bmp signaling in the dorsal midline has been implicated in the specification of ChP epithelial fate (Cheng et ...2002), signaling mechanisms that regulate ChP epithelium production and expansion remain ...
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Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development
... Shh signaling in the developing cerebellum around ...Shh signaling (Gli1-lacZ expression) in the developing anterior vermis and lobe IX was observed in two cell types, the proliferating GCPs in the outer ...
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Sonic Hedgehog signaling limits atopic dermatitis via Gli2 driven immune regulation
... Pharmacologic blockade of Smoothened caused exacerbation of Oxa-induced AD and Shh downregulation. Given that altering levels of Shh in skin by constitutive genetic mutation changed disease outcome on AD induction, we ...
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<p>Sonic Hedgehog Signaling Contributes to Chronic Post-Thoracotomy Pain via Activating BDNF/TrkB Pathway in Rats</p>
... Shh signaling is a signaling pathway essential for the embryonic development, and its abnormalities will cause birth defects, tissue remodeling, stem cell regeneration and tumor ...Shh signaling is ...
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Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes
... Because the Shh/Fgf8 expression boundary is important for dorso- ventral patterning in the mid and upper face (39), the absence of Shh coupled with the ventral repositioning of Fgf8 could theoretically cause a ...
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Tissue specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate
... been shown to influence parathyroid and thymus organogenesis, although their precise roles are unclear (Gordon and Manley, 2011). Most relevant to this study, Bmp4 expression is expanded in pouch endoderm of Shh null ...
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Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics
... Most JBTS genes have been identified through linkage analy- sis in consanguineous families. Using such an approach, we have mapped a novel JBTS locus, JBTS12, to chromosome 15q25.3– q26.3 in an Egyptian family. One gene ...
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Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure
... Background: Primary cilia are small non-motile microtubule and cell membrane protrusions expressed on most vertebrate cells, including cortical and hippocampal neurons. These small organelles serve as sensory structures ...
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Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine
... Shh signaling pathway is a key regulator of postnatal ...Shh signaling pathway is impaired to varying degrees depending on the severity of the disease such as AMI, stroke, and PAD due to the mitigated ...
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Understanding the role of the Sonic Hedgehog signaling pathway in cerebellar development and medulloblastoma genesis
... GNPs with constitutive activation of Shh signaling are known to be the cellular source of Shh driven medulloblastomas (Gilbertson and Ellison, 2008). However, the histological heterogeneity makes it possible that ...
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Quantitative analyses link modulation of sonic hedgehog signaling to continuous variation in facial growth and shape
... decreased signaling in the brain affects the size of the FEZ and the growth potential of the facial mesenchyme, whereas increasing SHH-signaling above normal levels primarily affects the spatial ...
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The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation
... One possible reason for a more severe phenotype in the lateral cerebellum, and the different degrees of phenotypes in the vermis, is inefficient recombination of the Smo conditional mutant allele in the vermis compared ...
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FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
... cell-cell signaling mechanisms involving locally secreted signaling molecules (Jessell, ...ligand sonic hedgehog (SHH), which is produced by cells at the ventral midline of the spinal cord ...
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High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma
... the Sonic Hedgehog (SHH) signaling pathway contributing to carcinogenesis of some organs has been reported in the ...for Sonic Hedgehog (SHH), patched homolog-1 (PTCH-1), ...
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Original Article Activation of sonic hedgehog signaling attenuates oxidized low-density lipoprotein-stimulated brain microvascular endothelial cells dysfunction in vitro
... of sonic hedgehog (SHH) in the oxidized low-density lipo- protein (oxLDL)-induced blood-brain barrier (BBB) ...SHH signaling components, such as SHH, Smo and Gli1, mRNA and protein levels were ...
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The effects of sonic hedgehog signaling pathway components on non small cell lung cancer progression and clinical outcome
... of sonic hedgehog (Shh) and glioma-associated oncogene homolog zinc finger protein 1 (Gli1) has been shown to affect lymphatic metastasis in cancer ...
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The Design, Synthesis, and Biological Evaluation of Steroid-Derived Inhibitors of the Sonic Hedgehog Signaling Pathway
... Since the discovery of cyclopamine and the unveiling of the relevance to cancer biology, there have been a number of approaches taken by pharmaceutical companies to develop novel Sonic Hedgehog inhibitors. ...
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Distinct temporal requirements for Sonic hedgehog signaling in development of the tuberal hypothalamus
... Shh signaling is required to establish distinct neuronal identities at ventral positions along the length of the vertebrate neural tube through activation and repression of homeodomain and basic helix- loop-helix ...
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