Sooty mangabey
Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV
... as sooty mangabeys, sustain high viral loads but do not develop disease, while nonnatural hosts, like rhesus macaques, develop ...in sooty mangabey lymphocytes, infection is medi- ated by the ...
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Selective Downregulation of Rhesus Macaque and Sooty Mangabey Major Histocompatibility Complex Class I Molecules by Nef Alleles of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2
... for sooty mangabey MHC class I alleles is much more limited, a recent analysis of 17 MHC class I sequences from two different animals identified eight Ceat-A and -B alleles with predicted cytoplasmic domain ...
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Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop.
... the sooty mangabey is the only animal species found to be infected with HIV-2-like lentiviruses (references 36 and 41 and Table ...forest-dwelling sooty mangabeys in a single, small feral troop ...
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Divergent Host Responses during Primary Simian Immunodeficiency Virus SIVsm Infection of Natural Sooty Mangabey and Nonnatural Rhesus Macaque Hosts
... natural sooty mangabey hosts avoid AIDS despite high levels of simian immunodefi- ciency virus (SIV) SIVsm replication, we inoculated mangabeys and nonnatural rhesus macaque hosts with an identical inoculum ...
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Acute SIV Infection in Sooty Mangabey Monkeys Is Characterized by Rapid Virus Clearance from Lymph Nodes and Absence of Productive Infection in Germinal Centers
... Sooty mangabey (SM) monkeys (Cercocebus atys) are one of many species of Old World African nonhuman primates that serve as natural reservoir hosts of simian immunodeficiency virus (SIV) infection ...
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Cloning and Analysis of Sooty Mangabey Alternative Coreceptors That Support Simian Immunodeficiency Virus SIVsmm Entry Independently of CCR5
... of sooty mangabey CD4 support SIVsmm Env-mediated entry via CCR5in ...two sooty mangabey alleles of CD4 (smCD4 ...without sooty mangabey CCR5 ...
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Isolation and Characterization of a Neuropathogenic Simian Immunodeficiency Virus Derived from a Sooty Mangabey
... infected sooty mangabey (designated FGb) to rhesus and pig-tailed macaques resulted in the development of neurologic disease in addition to ...from sooty mangabeys, significant amino acid differences ...
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Genetic differences accounting for evolution and pathogenicity of simian immunodeficiency virus from a sooty mangabey monkey after cross-species transmission to a pig-tailed macaque.
... Apart from point mutations in SUgpl20, a unique cluster of five nucleotide changes at positions 7205 to 7211 was observed that led to three amino acid changes: amino acids 378 to 380 are[r] ...
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Isolation of a simian immunodeficiency virus related to human immunodeficiency virus type 2 from a west African pet sooty mangabey.
... To determine the extent of serological cross-reaction between SIVsmLIB1 and other primate lentiviruses, gradient-purified virus was reacted in an immunoblot with serum samples from HIV-1[r] ...
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Comparative transcriptomics of extreme phenotypes of human HIV 1 infection and SIV infection in sooty mangabey and rhesus macaque
... macaques. In contrast, VNPs exhibited lower expression of interferon-stimulated genes and shared a common gene regulation profile with nonpathogenic SIV-infected sooty mangabeys. A short list of genes associated ...
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Simian Immunodeficiency Virus Utilizes Human and Sooty Mangabey but Not Rhesus Macaque STRL33 for Efficient Entry
... FIG. 7. smSTRL33 mediates efficient SIV entry. (A) Sequence variations at the N terminus of STRL33 derived from humans (hu), rhesus macaques (rh), sooty mangabeys (sm), pig tail macaques (ptm), and African green ...
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Primary Sooty Mangabey Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2 nef Alleles Modulate Cell Surface Expression of Various Human Receptors and Enhance Viral Infectivity and Replication
... Although sooty mangabeys are not entirely resistant to SIV- induced disease (35), they are clearly less susceptible to the development of immunodeficiency than infected rhesus ma- caques, which often develop ...
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Vocal correlates of individual sooty mangabey travel speed and direction
... of sooty mangabeys of approximately 90 individuals at Taı¨ National Park in Coˆte d’Ivoire (Range & Fischer, 2004; Janmaat, Byrne & Zuberbu¨hler, 2006; McGraw, Zuberbu¨hler & Noe¨, ...
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Simian Immunodeficiency Virus from the Sooty Mangabey and Rhesus Macaque Is Modified with O-Linked Carbohydrate
... the sooty manga- bey interacts with SIVsm in a way that favors the maintenance of the presence of an O-linked carbohydrate attachment site in the V1 domain of the virus gp120, while in the human, the virus favors ...
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Molecular and biological analyses of quasispecies during evolution of a virulent simian immunodeficiency virus, SIVsmmPBj14.
... infected sooty mangabey monkey (Cercocebus atys) and induces a slowly progressive AIDS-like disease after experimental infection of rhesus (Macaca mulatta) and pig-tailed (20, 21, 23) macaques, but it is ...
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Diverse Host Responses and Outcomes following Simian Immunodeficiency Virus SIVmac239 Infection in Sooty Mangabeys and Rhesus Macaques
... the sooty mangabey, modest increases of IL-4 and/or IL-10 were ...the sooty mangabeys, the presence of IL-10 but not IFN-g or IL-2 secretion during acute infection can be associated with lack of ...
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Serum Relationships within the Family Cercopithecidae
... Anubis baboon, Papio anubis Yellow baboon, Papio cynocephalus Sooty mangabey, Cercoccbus torquatus atys a Sooty manRabcy, 'ercocebus torquatus atys b Rhesus macaque, Macaca mulatta a Rhe[r] ...
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Th-1-Type Cytotoxic CD8+ T-Lymphocyte Responses to Simian Immunodeficiency Virus (SIV) Are a Consistent Feature of Natural SIV Infection in Sooty Mangabeys
... the sooty mangabey, is associated with high viral loads, it has been speculated that antiviral CD8 ⫹ T lymphocytes are limited or absent in sooty mangabeys and that their presence might actually ...
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Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques
... sooty mangabey cohort limited our ability to perform detailed kinetic assessments of type I IFNs, each nonhuman primate species clearly showed an upregulation of IFN- ␣ /  at 14 days postinfection (dpi) of ...
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Molecular Epidemiology of Simian Immunodeficiency Virus SIVsm in U.S. Primate Centers Unravels the Origin of SIVmac and SIVstm
... four sooty mangabey (SM) colonies in the United States to characterize simian immunodeficiency virus SIVsm diversity in SMs and to trace virus circulation among different primate centers (PCs) over the past ...
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