Sp1 transcription factor
Differential Regulation of Hepatitis B Virus Gene Expression by the Sp1 Transcription Factor
... the Sp1 binding site in the ENII ...another Sp1 binding site, which we named ...this Sp1 binding site in HBV gene expression, a C-to-A mutation at nt 1630 was introduced into this ...the Sp1-3 ...
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Sp1 transcription factor is required for in vitro basal and Tat-activated transcription from the human immunodeficiency virus type 1 long terminal repeat.
... above, Sp1-binding sites are important for basal and Tat-activated transcription, and thus Sp1 itself was a candidate for the factor that restores HIV-1 ...of Sp1, the proteins ...
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Characterization of functional Sp1 transcription factor binding sites in the hepatitis B virus nucleocapsid promoter.
... To investigate further the possibility that the same or similar factors might be binding to the nucleocapsid CpA, CpB, and CpC and major surface antigen B, D, D5', E, F, and F3' promoter[r] ...
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The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast like synoviocytes
... the protein concentration, samples (20 μg of total protein/ lane) were loaded and separated by electrophoresis on a 7.5% polyacrylamide gel (Bio-Rad Laboratories, Hercules, CA, USA) and then transferred to a ...
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Regulation of transcription from the hepatitis B virus major surface antigen promoter by the Sp1 transcription factor.
... The unique HBV XhoI site used in this construct is Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest The DNA-binding proteins which recognize the regulatory sequence eleme[r] ...
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In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.
... Transcriptional activation of homologous viral long terminal repeats by the human immunodeficiency virus type 1 or the human T-cell leukemia virus type 1 tat proteins occurs in the absen[r] ...
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The Epstein-Barr virus immediate-early promoter BRLF1 can be activated by the cellular Sp1 transcription factor.
... We demonstrate that the BRLF1 promoter has high constitutive activity in C-33 cells an epithelial cell line and that the proximal Spl-binding site is required for this activity.. Despite[r] ...
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Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia
... [6,19]. Sp1 protein expression has been reported to increase in tumor cells under hypoxic conditions ...the Sp1 transcription factor binds to ADAM17, as the pro- moter region of ADAM17 ...
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Regulation of the ITGA2 Gene in prostate cancer
... with transcription factors within the chromatin ...a factor that is affected by CpG methylation (Bell et ...the Sp1 transcription factor at the promoter appears to confer resistance to ...
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Identification and characterization of regulatory elements in the promoter of ACVR1, the gene mutated in Fibrodysplasia Ossificans Progressiva
... for Sp1, although Sp1 appears to induce different degrees of acti- vation in the various cell lines ...the Sp1 transcription factor participates not only at the level of minimal ...
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Semen Exosomes Promote Transcriptional Silencing of HIV-1 by Disrupting NF-κB/Sp1/Tat Circuitry
... B/Sp1 transcription factor pathway is implicated in SE-mediated control of HIV-1 ...for Sp1 (A) and NF- B p65 (B) by ...of Sp1 (D) and NF- B p65 (E) bands by ImageJ ...for ...
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MDM2 promoter SNP285 and SNP309; phylogeny and impact on cancer risk
... the Sp1 transcription factor as compared to the SNP309T-allele (22% increase in binding ...reduced Sp1-binding to the MDM2 promoter (51% decreased binding ...towards Sp1 as compared to ...
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DNA methylation status of TBX20 in patients with tetralogy of Fallot
... potential transcription factor binding sites for Sp1 ...the Sp1 expression plasmid pcDNA3.1-Sp1 and cotransfected HEK293T and HL-1 cells with a luciferase reporter gene driven by ...
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LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms
... anti-inflammatory factor and pleiotropic cytokine produced by a variety of cell types among which mono- cytes/macrophages are the main sources ...the transcription factor Sp1 plays an impor- ...
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The major transcriptional transactivation domain of simian virus 40 large T antigen associates nonconcurrently with multiple components of the transcriptional preinitiation complex.
... Most DNA tumor viruses encode transcriptional activators. Many of these activators have been shown to interact with multiple components of the preinitiation complex. We have shown here that SV40 Tag binds at least four ...
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Naturally occurring mutations in the human 5 lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription
... 10 Sp1 binding motifs, five of which occur in a single tan- dem repeat of the consensus binding ...that Sp1 could bind to this region of DNA, suggesting that Sp1 binding was a critical component re- ...
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Wnt/β catenin regulation of the Sp1 related transcription factor sp5l promotes tail development in zebrafish
... Wnt signaling is required for production of both somitic mesoderm and notochord in the caudal tail Zebrafish wnt3a is required for formation of caudal notochord, which is missing in nearly all wnt3a MO embryos. Since ...
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Synergistic targeting of Sp1, a critical transcription factor for myeloma cell growth and survival, by panobinostat and proteasome inhibitors
... the transcription factor Sp1 was overexpressed in MM cells, the Sp1 inhibitor terameprocol induced MM cell death in parallel with reduction of IRF4 and ...of Sp1 protein levels in MM ...
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Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex
... reverse transcription to limit the error rate of DNA synthesis or, alternatively, could participate in the induction of cell cycle ...factors Sp1 (76) and TFIIB ...
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Regulation of microRNAs by epigenetics and their interplay involved in cancer
... The deregulated miRNAs that can be controlled by epigenetic drugs in human cancers are shown in Table 1. These agents can either cause the re-expression of si- lenced tumor suppressor miRNAs or repress oncogenic miRNAs ...
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