specific role
Targeted treatments for multiple myeloma: specific role of carfilzomib
... Abstract: Carfilzomib is a selective, irreversible proteasome inhibitor, initially approved in the US in 2012 as single-agent therapy for relapsed and refractory multiple myeloma. Numerous Phase II studies have evaluated ...
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Update on the management of inflammatory bowel disease: specific role of adalimumab
... Inflammatory bowel diseases (IBD) are lifelong intestinal inflammatory conditions of unknown etiology, characterized by remissions and exacerbations. The main phenotypes of IBD are Crohn’s disease (CD) and ulcerative ...
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A specific role for the thalamus in mediating the interaction of attention and arousal in humans
... condition- specific effects within sessions (simple subtraction analysis); (2) condition-specific effects between sessions (conjunction and interaction analysis); (3) nonspecific hemodynamic changes between ...
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The control of target training zone and its specific role in the performance of physical activities
... we can conclude from this study that it is important to understand the basic knowledge of HR, the calculations made for the use of HR, the correct use of instruments such as the heart rate monitors, so that the training ...
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Aflibercept in wet AMD: specific role and optimal use
... Background: Vascular endothelial growth factor (VEGF) is a naturally occurring glycoprotein in the body that acts as a growth factor for endothelial cells. It regulates angiogenesis, enhances vascular permeability, and ...
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Multikinase inhibitors in the treatment of thyroid cancer: specific role of lenvatinib
... At a minimum of 8 months’ follow-up, 36% of patients had a partial response, 29% had durable stable disease (for more than 23 weeks), median progression-free survival was 9 months (12[r] ...
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A specific role for serotonin in overcoming effort cost
... the specific hypothesis that serotonin regulates the weight of effort cost in action production, as opposed to the weight of expected ...the specific effect of serotonin on cost-related parameters, and ...
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Strain-Specific Role of RNAs in Prion Replication
... cyclic amplification (PMCA) in a strain-specific fashion. While the addition of RNA restored PMCA conversion efficiency, the effect of synthetic polynucleotides or DNA was strain dependent, showing a different ...
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Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation
... After transient focal cerebral ischemia, cyclin Dl and Cdk4 were selectively expressed in morphologically intact or altered oligodendrocytes and neurons localized to the is- chemic tissue. Apoptotic cells were not ...
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Rapid and Non Invasive Screening System for Early Detection of Diabetic Retinopathy via Auto Fluorescence of Falvin Proteins
... the specific role of falvin proteins auto fluorescence in diabetic retinopathy and probe the difference of fluorescence signals between diabetic retinopathy and general retinopathy, the flu- orescence ...
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BK Polyomavirus specific T cell immune responses in kidney transplant recipients diagnosed with BK Polyomavirus associated nephropathy
... Results: We included 12 KT recipients diagnosed with BKPyVAN (7 proven, 4 presumptive, and 1 possible). Those with presumptive BKPyVAN had a median plasma BKPyV DNA load of 5.9 log10 copies/ml (interquartile range [IQR]: ...
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Smooth muscle cell–specific fibronectin EDA mediates phenotypic switching and neointimal hyperplasia
... antibodies specific for Fn-EDA+ (FN-3E2, 1:100; MilliporeSigma), vimentin (1:100; Abcam), osteopon- tin (1:100; Abcam), smooth muscle myosin heavy chain 11 (SM-MHC; 1:100; Abcam), smooth muscle 22-alpha (SM22α; ...
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Role of interleukin 10 in specific immunotherapy
... a role for IL-10 in tumor specific anergy ...of specific anergy in mice and humans requires high amounts of antigen or T cell epitope peptides applied by oral or subcutaneous routes (44, ...in ...
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The genesis of cystic fibrosis lung disease
... scellular pathway in normal tissues, they are predicted to absorb more than CF tissues (19). To continue this catalog of possible differences, in epithelia with high water perme- ability, maintenance of an osmotic ...
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Verb polysemy and frequency effects in thematic fit modeling
... well-fitting role-fillers for more polysemous verbs ...well-fitting role-fillers for less polysemous verbs (“jail crimi- nal”)? (2) Is a prototypical role-filler of a polyse- mous verb’s ...
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The Care Quality Commission‟s commitment to safeguarding
... 3.2 The statutory guidance Working Together to Safeguard Children was revised in March 2010 and is helpfully explicit about CQC‟s role and that of individual organisations. It also recognises that it is most ...
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Evaluation and future orientation of Council Regulation (EC) No. 1292/96 on food aid policy and food aid management and special operations in support of food security. Communication from the Commission to the Council and the European Parliament. COM (2001) 473 final/2, 12 September 2001
... Regulation No. 1292/96 enables the Commission to provide assistance to developing countries to overcome temporary food shortages, manage post-crisis rehabilitation and recovery, and address problems of long-term food ...
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Retinal waves are likely to instruct the formation of eye-specific retinogeniculate projections
... What features of retinal waves are instructive for eye-spe- cific segregation? We can start to answer this question by comparing the effects on eye-specific segregation of three manipulations that preserve waving ...
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The role of prothrombin complex concentrates in reversal of target specific anticoagulants
... Anticoagulation is a routine intervention for the manage- ment of arterial and venous thromboembolic events across a wide variety of clinical situations. Despite the robust clinical history of anticoagulant development ...
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Palmitoylation Plays a Role in Targeting Vac8p to Specific Membrane Subdomains
... During cell division, most cytoplasmic organelles are actively distributed to the new daughter cells. In budding yeast, the distribution of vacuoles initiates early in the cell cycle (1); a portion of the mother vacuole ...
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