Spike protein (S)
Mutation hot spots in Spike protein of COVID-19
... While many mutations have been identified in the S protein, there are portions of S protein that remained unchanged and might be conserved. These are the portions lying between 241-320; ...
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Analysis of the receptor-binding site of murine coronavirus spike protein.
... It has been found that a domain composed of 330 amino acids of the N terminus of murine coronavirus spike protein [S1N(330)] is involved in receptor-binding activity (H. Kubo, Y. K. Yamada, and F. Taguchi, ...
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Saliva Glycoproteins Bind to Spike Protein of SARS-CoV-2
... saliva protein in competing with the antibody binding to Spike protein at the titer of 1:6075 to ...the Spike protein’s glycoprotein-binding domains ...
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S1 domain of the porcine epidemic diarrhea virus spike protein as a vaccine antigen
... 1B, spike (S), ORF3, envelope (E), membrane (M) and nucleocapsid ...The S protein is present at the outer surface of the virion and is 1386 amino acid long ...The spike protein ...
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Epigallocatechin-gallate and Theaflavin-gallate interaction in SARS CoV-2 spike-protein central-channel with reference to the hydroxychloroquine interaction: Bioinformatics and Molecular Docking Study.
... viral spike protein destabilizing drug, MD study was performed using PatchDock where best 20 docking results for each interactions were considered for position specific docking posture analysis and ...
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Identification of NCAM that interacts with the PHE CoV spike protein
... PHE-CoV spike protein will facilitate the description of the binding domain of the spike protein, which will pre- sumably be the most effective target epitope for a spike ...
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Activation of the Alphavirus Spike Protein Is Suppressed by Bound E3
... alphavirus spike is a trimer of the E1-E2 heterodimer (6, 19, 42, ...the spike subunits into the heterodimer and the subsequent trimeriza- tion of the heterodimers into spikes take place in the rough ...
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Murine coronavirus membrane fusion is blocked by modification of thiols buried within the spike protein.
... Cysteine blockade did not affect S binding to cellular recep- tor but did prevent the further structural changes in the protein that are required for fusion function. This brings up the ques- tion of what ...
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Mapping of the Coronavirus Membrane Protein Domains Involved in Interaction with the Spike Protein
... and S genes, respectively, cloned in pTUG31 (37, ...hybrid protein EAV M⫹9A has been described previ- ously (5). This hybrid protein has an insertion of 9 amino acids, corresponding to the MHV M ...
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Modulation of the Unfolded Protein Response by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein
... Induction of ER stress by S protein has a significant impact on cell homeostasis and may contribute to viral pathogenesis. For example, the UPR is activated in response to the release of ER calcium as ...
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Fusion formation by the uncleaved spike protein of murine coronavirus JHMV variant cl-2.
... 1195 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest The fusogenic properties of the uncleaved spike S protein of murine coronavirus JHMV variant cl-2 were studied by ex[r] ...
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Proteolytic Activation of the Spike Protein at a Novel RRRR/S Motif Is Implicated in Furin-Dependent Entry, Syncytium Formation, and Infectivity of Coronavirus Infectious Bronchitis Virus in Cultured Cells
... IBV S protein may preferentially occur at the S1/S2 site, as a putative N-terminal cleavage intermediate up to the second site was not detected in the infected cells, although S1, S2, and the dual-cleavage ...
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Receptor-Induced Conformational Changes of Murine Coronavirus Spike Protein
... revertant S pro- teins. We examined whether the S proteins of wt JHMV cl-2 and revertants derived from srr7 undergo conformational changes similar to those of srr7 following the interaction with ...the ...
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Spike protein-nucleocapsid interactions drive the budding of alphaviruses.
... 4737 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Semliki Forest virus SFV particles are released from infected cells by budding of nucleocapsids through plasma membr[r] ...
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Semliki Forest Virus Budding: Assay, Mechanisms, and Cholesterol Requirement
... radiolabeled spike proteins released in the post-biotin incubation media were recovered by acid precipitation of the media (lanes 1 and ...radiolabeled spike proteins were released from the biotinylated ...
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Spike protein oligomerization control of Semliki Forest virus fusion.
... 5214 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We have recently shown, using cleavage-deficient mutants of the p62-El membrane protein complex of Semliki Forest v[r] ...
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A Rotavirus Spike Protein Conformational Intermediate Binds Lipid Bilayers
... of spike-like projections and an extended outer shell, respectively, as illustrated in ...the spike-like VP4 projections do not form, and its various domains are probably flexibly linked ...a spike, ...
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Murine Coronavirus Requires Lipid Rafts for Virus Entry and Cell-Cell Fusion but Not for Virus Release
... viral spike protein became associated with lipid rafts ...viral S protein with lipid rafts is critical for virus ...viral S protein after virus binds to ...with S ...
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PubMedCentral-PMC5380844.pdf
... The spike protein of this virus is distinct from the MERS-CoV spike, sharing only 46% amino acid identity, and it appears unable to enter cells that express the functional receptor used by MERS-CoV ...
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TMPRSS2 Protease Inhibitors May Prolong But Heparins Accelerate SARS-CoV-2 Clearance
... of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease 28. TMPRSS2[r] ...
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