Spinal Dorsal Horn
TWIK Related Spinal Cord K+ Channel Expression Is Increased in the Spinal Dorsal Horn after Spinal Nerve Ligation
... in spinal cord neurons 14 days after SNL in ...lumbar spinal dorsal horn between TRESK, neuron, and astrocyte markers showed that TRESK was mainly located in neurons, but not astrocytes at 14 ...
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MHC-I promotes apoptosis of GABAergic interneurons in the spinal dorsal horn and contributes to cancer induced bone pain
... the spinal cord of tumor-bearing rats ...rats’ spinal cord lymphocytes showed that CD8 + T cells (CD3 + CD8 + ) composed of 74% ± ...the spinal cord contrasted with the constant 1 to ...the ...
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<p>Systemic Injection of Thalidomide Prevent and Attenuate Neuropathic Pain and Alleviate Neuroinflammatory Response in the Spinal Dorsal Horn</p>
... the spinal dorsal horn of Tha posttreatment with multiple intraperitoneal injections, 96 rats were divided into 4 groups: Sham+Veh group (n = 12), Sham+Tha group (n=12), SNL+Veh group (n = 36) and ...
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Key role for spinal dorsal horn microglial kinin B1receptor in early diabetic pain neuropathy
... Four days after injection of STZ, rats were anesthetised with CO 2 inhalation and then decapitated. The upper thoracic spinal cord (T1-T2) was isolated and approxi- mately 10 mg of tissue were put in RNAlater ...
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Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib
... the spinal cord in rodent models with CCI, and modulations of SIRT1 activity by resvera- trol ameliorated the development of CCI-induced neuro- pathic pain [13, 14, ...the spinal dorsal horn ...
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Phosphorylation state–dependent modulation of spinal glycine receptors alleviates inflammatory pain
... in inflammation-induced inhibition of synaptic GlyR currents in the superficial spinal dorsal horn (ref. 6 and Figure 3A; note that the GlyR α1 subunit lacks this consensus site). In order to provide ...
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Original Article Involvement of P2X7 receptors and downstream ERK pathways in chronic inflammatory pain
... the spinal dorsal horn, were upregulated after the hind paws of mice were injected with ...the spinal dorsal horn may play a role in the onset and development of chronic pain ...
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Original Article Inhibition of GAP-43 by propentofylline in a rat model of neuropathic pain
... L5 spinal nerve transection model of mechanical pain hyper- sensitivity, GAP-43 was found to be up-regulat- ed in the spinal dorsal horn from 5 up to 10 days after injury ...
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Periaqueductal grey EP3 receptors facilitate spinal nociception in arthritic secondary hypersensitivity
... A total of 42 naive and 60 arthritic animals were used in these experi- ments. In 15 arthritic animals, EMG experiments could not be performed due unattainable or unstable baseline EMG thresholds and these were excluded ...
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The effect of exercise frequency on neuropathic pain and pain-related cellular reactions in the spinal cord and midbrain in a rat sciatic nerve injury model
... the spinal dorsal horn in relation to the development of mechanical hypersensitivity, the co-localization of the goat anti-Iba1 antibody (1: 100 in PBS, ab 5076, Abcam) with rabbit anti-BDNF antibody ...
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TLR4-mediated autophagic impairment contributes to neuropathic pain in chronic constriction injury mice
... One of the best-known autophagic substrates is p62/ SQSTM1, a key LC3-binding protein, which serves as a link between LC3 and ubiquitinated proteins [27]. p62 and p62-bound polyubiquitinated proteins become incorporated ...
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Development of Spinal Neuronal Hyperexcitability and Structural Plasticity after Cervical Facet Injury: Implications for Modulating Persistent Pain
... disorders. Spinal neuronal hyperexcitability is a common feature of persistent pain that can be induced by enhanced excitatory signaling in the dorsal ...horn. Spinal dorsal horn ...
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Central modulation of pain
... the spinal cord, opioids can inhibit transmitter release from primary afferent terminals as well as activity of pain transmission ...of spinal norepinephrine ...
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The role of spinal GABAB receptors in cancer-induced bone pain in rats
... shown in Figures 2A-B and 3A-B, the expression of GABABR1 and GABABR2 protein were significantly and time dependently decreased in CIBP rats, beginning at day 7 after TCI and remained at low levels until day 21, the last ...
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Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice
... and spinal cords were dissected. Each hemibrain and spinal cord was placed in Accustain (a pro- prietary formalin-free fixative from Sigma-Aldrich, ...and spinal cord were stored in 70% ethanol at ...
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Reverse transcription quantitative real time polymerase chain reaction reference genes in the spared nerve injury model of neuropathic pain: validation and literature search
... The more the M-value tends to zero, the more the candidate gene is stable compared to the other tested genes. Hence the stability of the different genes can be ranked. A first approximate classification was established ...
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Diabetes induced microvascular complications at the level of the spinal cord: a contributing factor in diabetic neuropathic pain
... Nikita Ved obtained her PhD at UCL on anti-angiogenic therapy for diabetic retinopathy, whilst also researching spinal cord involvement in diabetic neuropathy. This sparked her interest in diabetic complications, ...
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Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn
... the dorsal spinal cord (this ...a dorsal spinal cord with nearly a complete loss of inhibitory GABAergic neurons with an increase in glutamatergic ...
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VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis
... Eight and 11 days after induction of articular inflammation rats were terminally anesthetized with sodium pentobarbital (60 mg/ml) and perfuse-fixed with 250 mL ice cold PBS + heparin (1U/mL) followed by 250 mL ice cold ...
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The spinal anti-inflammatory mechanism of motor cortex stimulation: cause of success and refractoriness in neuropathic pain?
... in spinal P2X4 reactivity (Figure 4A, C), which was partially reversed in MCS-responsive rats (Figure 4A, D) when com- pared with sham-operated animals (Figure 4A, ...
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