Spindle checkpoint
Two Complexes of Spindle Checkpoint Proteins Containing Cdc20 and Mad2 Assemble during Mitosis Independently of the Kinetochore in Saccharomyces cerevisiae
... of checkpoint proteins that were assembled into complexes by size exclusion chromatog- ...the checkpoint proteins (Bub3, Mad2, and Mad3), Cdc20, and APC (Cdc27) present in nocodazole-treated yeast ...(E) ...
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Baumann, Christoph (2007): Plk1 regulates PICH, a centromere-associated SNF2 family tranlocase that is required for the spindle checkpoint. Dissertation, LMU München: Fakultät für Biologie
... with checkpoint activity status (Ahonen et ...inhibitory spindle checkpoint signal remains ...the spindle checkpoint somehow ‘senses’ the tension that develops between sister ...
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Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint
... for checkpoint inactivation and con- tributes to the dissociation of Cdc20 from Mad2 and pos- sibly the disassembly of ...a spindle checkpoint component through an RNA interference (RNAi) screen ...
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DRG1 is a potential oncogene in lung adenocarcinoma and promotes tumor progression via spindle checkpoint signaling regulation
... and spindle assembly checkpoint proteins (Mad2 and BubR1) were confirmed as the interaction protein of DRG1 in ...mitotic spindle checkpoint pathway, and MAD2 overexpression is observed in ...
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Genetic analysis of the spindle checkpoint genes san-1, mdf-2, bub-3 and the CENP-F homologues hcp-1 and hcp-2 in Caenorhabditis elegans
... or spindle checkpoint function and do not have severe embryonic lethality ...known spindle checkpoint genes, mdf-1 and mdf-2, and the predicted kinetochore protein kbp-5 ...the spindle ...
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Lesions in Many Different Spindle Components Activate the Spindle Checkpoint in the Budding Yeast Saccharomyces cerevisiae
... the spindle the MAD- gation in cells whose spindles are defective (reviewed dependent spindle checkpoint detects, we combined in Rudner and Murray 1996; Wells ...The spindle checkpoint ...
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Cell Cycle Arrest in cdc20 Mutants of Saccharomyces cerevisiae Is Independent of Ndc10p and Kinetochore Function but Requires a Subset of Spindle Checkpoint Genes
... The spindle checkpoint ensures accurate chromosome segregation by inhibiting anaphase onset in response to altered microtubule function and impaired kinetochore ...the spindle checkpoint in ...
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Human Papillomavirus Oncoproteins E6 and E7 Independently Abrogate the Mitotic Spindle Checkpoint
... the metabolic inhibitor PALA as well as CAD gene amplifica- tion (64). In contrast, E7-expressing cells display massive cell death with the rare appearance of PALA-resistant aneuploid cells, which occurs by a ...
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Characterization of a murine hypomorphic allele of the spindle checkpoint gene Bub1 and its role in tumorigenesis
... defective spindle checkpoint, chromosome segregation errors, and increased ...tested spindle checkpoint responses of Bub1 ∆2-3/∆2-3 , Bub1 ∆2-3/+ and WT MEFs by measuring mitotic indeces ...
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The Spindle Checkpoint of the Yeast Saccharomyces cerevisiae Requires Kinetochore Function and Maps to the CBF3 Domain
... the spindle checkpoint in null mutants lacking kinetochore activity in the yeast Saccharomyces ...in checkpoint signaling in S. cerevisiae. Spindle checkpoint activity maps to a ...
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Bub3p facilitates spindle checkpoint silencing in fission yeast
... for spindle check- point ...after spindle refor- ...the spindle checkpoint and subsequently shifted to their permissive temperature of ...a spindle and committed to anaphase within 10 ...
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Cell-based expression cloning for identification of polypeptides that hypersensitize mammalian cells to mitotic arrest
... Microtubule inhibitors such as Vinblastine and Paclitaxel are chemotherapy agents that activate the mitotic spindle checkpoint, arresting cells in mitosis and leading to cell death. The pathways that ...
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Overlapping Roles of the Spindle Assembly and DNA Damage Checkpoints in the Cell-Cycle Response to Altered Chromosomes in Saccharomyces cerevisiae
... D2-dependent spindle checkpoint blocks anaphase until all chromosomes have achieved success- ful bipolar attachment to the mitotic ...of spindle checkpoint function may be to protect cells ...
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Can Induce Chromosomal Instability through Targeted Degradation of the Mitotic Checkpoint Kinase Bub1
... in spindle checkpoint signaling. Bub1 also recruits other spindle checkpoint proteins to the kinetochore, forming the mitotic checkpoint complex (MCC) ...
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The Role of Cdh1p in Maintaining Genomic Stability in Budding Yeast
... the spindle checkpoint, which is pression of many genes, including some cell cycle regu- functional in these cells, but is ameliorated by over- latory genes (Cross et ...in spindle assembly or ...
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Akt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization
... ry proteins. The metabolism of the cyclin B-Cdc2 com- plex is known to be regulated by its interaction with Cks(s) [in Homo sapiens, CKsHs(s)] (77, 78) and by spin- dle sensor proteins, such as MAD2 (79–81). Therefore, ...
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The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond
... taining spindle checkpoint activity ...the spindle assembly checkpoint ...a spindle checkpoint- dependent arrest in mitosis ...tension-specific checkpoint branch, but an ...
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Merotelic attachments and non-homologous end joining are the basis of chromosomal instability
... in spindle regulation could result in an increase in merotelic attachments that escape detection, giving rise to aneuploidy and chromosome breakage ...the spindle checkpoint and delays mitosis ...
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Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
... The spindle assembly checkpoint is a complex signal transduction cascade that inhibits the metaphase to ana- phase transition in the presence of unattached or untensed ...the spindle check- point is ...
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Consequences of Defective Tubulin Folding on Heterodimer Levels, Mitosis and Spindle Morphology in Saccharomyces cerevisiae
... the spindle check- point halts the cell cycle and thereby prevents chromo- some missegregation (A mon ...the spindle check- point, MAD2, in appropriate diploid strains and then sporulated them to recover ...
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