/spl beta/-C/sub 3/N/sub 4/
α<sub>v</sub>β<sub>3</sub> integrin-targeted micellar mertansine prodrug effectively inhibits triple-negative breast cancer in vivo
... The in vivo biodistribution studies were performed by tail vein injection of cRGD-MMP or MMP (dosage: 5 mg DM1 equiv./kg) to MDA-MB-231 tumor-bearing nude mice, and DM1 amounts in the tumor and major organs were ...
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Preparation and characterization of magnetic nanoparticles containing Fe<sub>3</sub>O<sub>4</sub>-dextran- anti-β-human chorionic gonadotropin, a new generation choriocarcinoma-specific gene vector
... ° C for 1 ...° C, and the reactions were stopped by addition of 2M H 2 SO 4 (50 µ L/ ...Fe 3 O 4 -dextran-anti- β -HCG nanoparticle/OD anti- β -HCG monoclonal antibody × ...
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Fe<sub>3</sub>O<sub>4</sub>-based PLGA nanoparticles as MR contrast agents for the detection of thrombosis
... ° C ± 1 ° C, 55% ± 15% humidity, and 12 h light/dark cycle) and had free access to water and ...= 4). Then, Fe 3 O 4 -PLGA or Fe 3 O 4 -PLGA-cRGD NPs at a final dosage of ...
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Novel agonist of α<sub>4</sub>β<sub>2</sub>* neuronal nicotinic receptor with antinociceptive efficacy in rodent models of acute and chronic pain
... Male Sprague Dawley rats were anesthetized with chloral hydrate (400 mg/kg i.p.), and a heating pad was used to maintain their rectal temperatures at 36.5 ± 0.5°C. The right jugular vein was cannulated for ...
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Vancomycin-modified Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@Ag microflowers as effective antimicrobial agents
... Fe 3 O 4 @ SiO 2 @Ag ...Van/Fe 3 O 4 @SiO 2 @Ag microflowers (Figure 3B and ...Fe 3 O 4 @SiO 2 @Ag microflowers are surrounded by a thin membrane-like layer with ∼ ...Fe 3 ...
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RGD-conjugated gold nanorods induce radiosensitization in melanoma cancer cells by downregulating α<sub>v</sub>β<sub>3</sub> expression
... Figure 4 Enhancement of radiation-induced apoptosis by RGD-GNRs. A375 cells were treated with either gold nanorods or RGD-GNRs for one hour prior to irradiation. The cells were stained with Annexin V and propidium ...
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Daunorubicin-loaded magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> overcome multidrug resistance and induce apoptosis of K562-n/VCR cells <em>in vivo</em>
... Fe 3 O 4 (MNPs-Fe 3 O 4 ) on K562-n/VCR cells in ...group C received MNPs-Fe 3 O 4 , and group D received DNR-loaded MNPs-Fe 3 O 4 ...and C, ...
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Effect of Fe<sub>3</sub>O<sub>4</sub>-magnetic nanoparticles on acute exercise enhanced KCNQ<sub>1</sub> expression in mouse cardiac muscle
... Forty-two mice were randomly assigned to either the non- exercised control group (n = 6) or exercise groups (n = 36). Thirty-six mice were placed into plastic cylinders (23 cm tall × 14 cm diameter) ...
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Integrin α<sub>v</sub>β<sub>3</sub>-targeted gold nanoshells augment tumor vasculature-specific imaging and therapy
... with similar particle concentrations ( ∼ 40 fmol) of untargeted and targeted NSs. The targeted NSs treatment group had more profound hemorrhage during treatment than the untargeted NSs treatment group. Greater amounts of ...
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In vitro toxicity of Fe<sub>m</sub>O<sub>n</sub>, Fe<sub>m</sub>O<sub>n</sub>-SiO<sub>2</sub> composite, and SiO<sub>2</sub>-Fe<sub>m</sub>O<sub>n</sub> core-shell magnetic nanoparticles
... NH 4 OH and 1% ammonium acetate was added to FeSO 4 and Fe 2 (SO 4 ) 3 (molar ratio 2:1) in 700 mL of distilled water under intensive stirring at a rate of 4 mL/min until the pH had ...
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Decreased bacteria activity on Si<sub>3</sub>N<sub>4</sub> surfaces compared with PEEK or titanium
... S. aureus, E. coli, and Enterococcus were obtained from American Type Culture Collection (Manassas, VA) (strains 35984, 25668, 25923, 26, and 6569, respectively). The dry pellet was rehydrated in 6 mL of Luria broth (LB) ...
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The effect of magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> on immune function in normal ICR mice
... Fe 3 O 4 -MNPs, were dissolved in normal saline and intravenously (iv) injected into mice ...at 4 ° C to separate plasma and blood ...° C for determination of ...
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NH<sub>4</sub>HCO<sub>3</sub> gas-generating liposomal nanoparticle for photoacoustic imaging in breast cancer
... (NH 4 HCO 3 ) solution, which is safe, effective, inexpensive, and free of side ...NH 4 HCO 3 decomposes to produce CO 2 , which can absorb much of the light energy under laser irradiation ...
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Biosafety evaluation of Janus Fe<sub>3</sub>O<sub>4</sub>-TiO<sub>2</sub> nanoparticles in Sprague Dawley rats after intravenous injection
... molecular weights. Immunoblots for expression of p38, p-p38, JNK, p-JNK, HO-1, ERK, c-Jun, cleaved caspase 3, Bcl2, Bax, P50, p53, Nrf2, Akt, and GAPDH were detected. All antibodies for Western blot in this ...
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Synthesis of composite magnetic nanoparticles Fe<sub>3</sub>O<sub>4</sub> with alendronate for osteoporosis treatment
... Dex/Fe 3 O 4 using the EDC–NHS crosslinking ...Bis/Dex/Fe 3 O 4 on the bone surface and thermalize by the RF ...Fe 3 O 4 particles. XRD revealed Fe 3 O 4 ’s cubic ...
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Immobilized transferrin Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub> nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery
... and C show the mean fluorescence intensity and the par- ent ratio of cancer cells, after incubation with TfDMP, and DOX-coupled DMP (without Tf modification) (DDMP), ...
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The changes of T lymphocytes and cytokines in ICR mice fed with Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles
... (Fe 3 O 4 ) nanoparticles with appropriate surface modification, which have been widely used experimentally for numerous in vivo applications, such as magnetic resonance imaging, tissue repair, immunoassay, ...
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Preparation and in vitro evaluation of doxorubicin-loaded Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles modified with biocompatible copolymers
... (FeCl 3 ⋅ 6H 2 O), ferrous chloride tetrahydrate (FeCl 2 ⋅ 4H 2 O), and ammonium hydroxide (25 wt%) were purchased from Fluka (Buchs, ...° C for 12 hours and used without further ...
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Magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> enhance docetaxel-induced prostate cancer cell death
... strategy is to treat tumor cells with antioxidants, such as through the dietary administration of red wine and green tea polyphenols to prevent cancer. The other strategy is to provide pro-oxidant therapy, which consists ...
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Effect of interaction of magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> and artesunate on apoptosis of K562 cells
... phase were cultured in 96-well flat-bottomed plates in a triplicate pattern and treated with different concentrations of ART, MNPs-Fe 3 O 4 , or the copolymer of ART with MNPs- Fe 3 O 4 in the ...
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