SR-BI cholesterol efflux
SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to high-density lipoprotein 3
... of cholesterol between cells and lipoproteins [4], while ABCG1 has been shown to promote free cholesterol (FC) efflux from macrophage to HDL and increase the accumulation of cholesteryl ester (CE) in ...
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Cholesterol binding, efflux, and a PDZ interacting domain of scavenger receptor–BI mediate HDL initiated signaling
... and cholesterol surrounding a lipid core of triglycerides and cholesteryl ...extrahepatic cholesterol to the liver for excretion into bile in a process known as reverse cholesterol ...Reverse ...
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Macrophage ABCA1 and ABCG1, but not SR BI, promote macrophage reverse cholesterol transport in vivo
... in cholesterol efflux to free apoA-I, the DKD cells had a greater than 85% reduction in cholesterol efflux to free apoA-I (Figure 6B), indicating that ABCA1 was effectively knocked down in ...
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An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI
... and SR-BI knockout mice have high plasma HDL but more advanced atherosclerotic lesions than their wildtype counter- ...creased cholesterol efflux from macrophages is con- sidered beneficial, ...
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Original Article Heat shock protein expression affects high-density lipoprotein function in atherosclerosis
... macrophage efflux rate with dose-depen- dent, decreased ABCA1, ABCG1, SR-BI, and LXR-α protein expression in liver tissue, sup- pressed serum IL-10 level, and elevated IFN-γ level, suggesting that ...
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Voluntary exercise increases cholesterol efflux but not macrophage reverse cholesterol transport in vivo in mice
... on cholesterol efflux and in vivo reverse cholesterol transport ...Macrophage cholesterol efflux towards plasma was significantly increased in running (n = 8) compared to sedentary (n = ...
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Human scavenger receptor class B, type II (SR-BII) and cellular cholesterol efflux
... 1.6.3.1), SR-BI was the first physiological HDL receptor to be identified ...uptake, SR-BI expression also correlates with HDL-mediated cellular cholesterol efflux from cultured ...
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USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages
... total cholesterol and phospho- lipids ...that cholesterol and phospholipid concentra- tions were elevated in the HDL fractions of Usf1 −/− mice as compared Usf1 +/+ mice ...affects cholesterol ...
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Hepatic expression of scavenger receptor class B type I (SR BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
... macrophage-derived cholesterol mass would clearly be desirable, it is impossible to detect the small pool of cholesterol mass derived specifically from ...mass efflux and RCT may not faithfully ...
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In vivo regulation of scavenger receptor BI and the selective uptake of HDL cholesteryl esters in rat liver parenchymal and Kupffer cells
... of SR-BI in the liver cell types as com- pared with a 5-day treatment with EE, with a decreased ex- pression in parenchymal cells and a 4-fold increased expression in Kupffer ...of SR-BI. It ...
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Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes
... lipoprotein cholesterol (LDL-C), influence preβ-HDL formation, hence mediat- ing the antioxidant effect of HDL and acting as an acceptor of sphingosine-1-phosphate (S1P) ...of cholesterol metabolism and ...
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A TRAIL-Delivered Lipoprotein-Bioinspired Nanovector Engineering Stem Cell-Based Platform for Inhibition of Lung Metastasis of Melanoma
... reverse cholesterol transport from peripheral tissues to liver ...a SR-BI-based hydrophobic channel on cell membrane when HDL binds to SR-BI, which promotes the efflux and ...
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13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages
... macrophage cholesterol homeostasis, such as liver × receptor a (LXRa), ATP-binding cassette trans- porter A1 (ABCA1), ABCG1 and scavenger receptor class B type 1 (SR-BI), and increases ...
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Advanced glycation end products increase lipids accumulation in macrophages through upregulation of receptor of advanced glycation end products: increasing uptake, esterification and decreasing efflux of cholesterol
... excessive cholesterol in the arterial ...Macrophage cholesterol homeostasis maintenance is the result of a balance among influx, endogenous synthesis, catabolism, and efflux ...and SR class A ...
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The role of cholesterol efflux in regulating the fertilization potential of mammalian spermatozoa
... of cholesterol in the membranes of the sperm head, and its role in ...HDLs), cholesterol is removed via a spe- cific pathway (HDL–SR-BI) and a nonspecific pathway ...sterol efflux, this ...
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The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity
... ANGPTL8 has been reported to present significant but contradictive relationship with various blood lipid markers. Genomic studies showed that ANGPTL8 gene variant was associated with HDL-C variant [16, 25]. The ...
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MicroRNA 33a regulates cholesterol synthesis and cholesterol efflux related genes in osteoarthritic chondrocytes
... To confirm that miR-33a regulates cholesterol efflux genes in a way that can be reversed by its inhibitor, we treated OA chondrocytes with anti-miR-33a. Introduc- tion of antisense oligonucleotides directed ...
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A Newly Integrated Model for Intestinal Cholesterol Absorption and Efflux Infers How Plant Sterol Intake Reduces Circulating Cholesterol Levels
... BBM and lumen promotes cholesterol efflux, and plant sterol in the BBM may disturb the trafficking 25.. machineries that transport cholesterol to the cell interior.[r] ...
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Scavenger Receptor Class B Is Required for Hepatitis C Virus Uptake and Cross-Presentation by Human Dendritic Cells
... variant SR-BII are physiologically relevant HDL receptors with an identical extracellular ...loop. SR-BII differs from SR-BI at the C terminus, which is reported to confer an intracellular ...
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Scavenger receptor BI plays a role in facilitating chylomicron metabolism
... HDL cholesterol to the bile ...murine SR-BI, a decrease in serum HDL cholesterol, apoAI, and apoAII levels was ob- served (37, ...LDL cholesterol, VLDL, and LDL-apoB were also ...
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