src-Family Kinases
Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction
... However, Src-family kinases (SFK) mediate cytoplasmic retention of pSTAT5A leading to attenuated target gene expression and colony formation in CML ...
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Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn
... The Src family kinases, of which Fyn and Lck are members, are tyrosine kinases related to Src which was first identified as a viral protein (v-Src) in Rous sarcoma virus ...
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Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport
... these Src-family tyrosine kinases does not seem to be species restricted since Lyn, Hck, and Fgr are also found in human red cells (21 and ...that Src- family kinases participate ...
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The role of Src family kinases in mediating M CSF receptor signaling and monocytic cell survival
... (RTK) family, which includes platelet-derived growth factor (PDGF) receptor, c-Kit and Flt3/Flt2 receptors ...as Src family kinases, PI3-kinase/Akt and Ras/MAPK leading to the induction of a ...
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The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases
... tyrosine kinases and phosphatases, but little is known about whether tyrosine phosphatases influence ...of SRC family kinases (SFKs), implicating CD148 as a critical positive regulator of SFK ...
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Targeting Drug-Sensitive and -Resistant Strains of Mycobacterium tuberculosis by Inhibition of Src Family Kinases Lowers Disease Burden and Pathology
... (23). Src family kinases (SFKs) are reported to influence cytokine signaling and inflammatory responses ...by Src in macrophages and epithelial cells stimulated with TNF- ␣ , LPS, or hypoxia ...
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Mouse avatar models of esophageal squamous cell carcinoma proved the potential for EGFR-TKI afatinib and uncovered Src family kinases involved in acquired resistance
... Methods: Six ESCC cell lines and 7 out of 25 PDX models derived from 188 biopsies with clear molecular features were employed to evaluate the sensitivity of several EGFR blockers in vitro and in vivo, as well as the ...
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Palatal adhesion is dependent on Src family kinases and p38MAPK
... shelves. Src family kinases (SFK) function downstream of both ...epithelium. Src, Fyn and Yes subfamily members were expressed in the palatal ...
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Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo
... showed epibolic arrest and deformed blastoderms (55– 60 % of injected embryos), clearly resembling the PrP-1 morphant phenotype (Fig. 2a and b). The combined Fyn / Yes knockdown produced a stronger effect than the single ...
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Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine
... that Src, which is over-activated following loss of expression of adenomatous polyposis coli (Apc), is required for colon cancer tumorigenesis ...to Src over- activation and in turn to colorectal cancer ...
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Regulation of the Src Family Kinases by Csk
... Because Csk lacks a transmembrane domain and fatty acyl modifications, it is predominantly present in cytosol, whereas its substrate SFKs are anchored to the membrane via their N-terminal myristate and palmitate ...
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Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system
... transducing kinases with cell surface receptors is not, however, ...Janus kinases are constitutively and stably associated with the GP130 cytokine receptor (Giese et ...the Src-interacting Na + /K + ...
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State and Role of Src Family Kinases in Replication of Herpes Simplex Virus 1
... Yes in the case of HEK293 and HEL cells). As shown in Fig. 4, the results were as follows. (i) At all three time points tested in mock-infected cells, phospho-Tyr416 was barely detectable, consistent with the current ...
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LYN expression predicts the response to dasatinib in a subpopulation of lung adenocarcinoma patients
... targeting SRC family kinases (SFKs) have shown efficacy in treating non-small cell lung cancer ...SFK family, is associated with patient survival, the efficacy of dasatinib, and/or NSCLC cell ...
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The Host Phosphoinositide 5-Phosphatase SHIP2 Regulates Dissemination of Vaccinia Virus
... or Src family kinases, perhaps acting redundantly (54), is required for localization of SHIP2 and that localization depends on N-WASP but not on the Arp2/3 com- plex or ...
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Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5
... 2 Src family kinases, Lyn and Hck, profoundly affects HSC differentiation, produc- ing hematopoietic progenitors with increased proliferation, reduced apoptosis, growth factor–independent survival, ...
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Systematic review of dasatinib in chronic myeloid leukemia
... and Src family kinases, and is approved for the treatment of chronic myeloid leukemia (CML) patients in chronic, accelerated, or blast phase with resistance or intolerance to imatinib therapy, for ...
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Cytoskeletal signaling proteins : complex regulatory mechanisms and roles in innate immunity
... Western blotting (Fig. 4.3A). Pyk2 was detected in Syk immune complexes and Syk was found in Pyk2 immune complexes. Interestingly, the Pyk2 auto-phosphorylation site is not required for this interaction, which suggests ...
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Variola and Monkeypox Viruses Utilize Conserved Mechanisms of Virion Motility and Release That Depend on Abl and Src Family Tyrosine Kinases
... of Src family kinases rather than Abl family ...other Src family tyrosine kinases have been implicated in various aspects of the immune response, including innate and ...
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Diverse Requirements for Src Family Tyrosine Kinases Distinguish Chlamydial Species
... Antibodies. The antichlamydia antibodies used were polyclonal rab- bit anti-C. trachomatis L2 EB, anti-C. pneumoniae EB, and anti-C. caviae EB. Monoclonal antibody L2-i-45 against C. trachomatis L2 major outer membrane ...
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