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Targeting Drug-Sensitive and -Resistant Strains of Mycobacterium tuberculosis by Inhibition of Src Family Kinases Lowers Disease Burden and Pathology

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Figure

FIG 1 Effect of Src inhibition on intracellular survival of drug-sensitive and drug-resistant strains ofMycobacterium tuberculosis in THP-1 macrophages
FIG 2 Src inhibition promotes phagosome acidification and autophagy inuntreated or treated with 20were treated with 20 Mycobacterium tuberculosis-infectedmacrophages
FIG 3AZD0530 reduces infection in guinea pigs infected with M. tuberculosis. Outbred Dunkin-Hartley guinea pigs (n � 5) were infected with M
FIG 4 Reduced pathological damage in lungs and spleens of guinea pigs infected with H37Rv upon AZD0530infected THP-1 macrophages that were either untreated or treated with AZD0530 (20treatment
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