Src Homology 2
The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase 1 and Notch signaling
... receptor 2 (VEGF-R2) activation and downstream signaling pathways required for tubular network ...between Src homology 2 domain-containing protein tyrosine phosphatase-1 (SHP-1) and VEGF-R2, ...
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src homology 2 domain–containing tyrosine phosphatase SHP 1 controls the development of allergic airway inflammation
... contains src homology 2 (SH2) domains is recognized as a negative regulator for various intracellular signal- ing molecules, including those downstream of the TCR and the IL-4 ...
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Deficiency of Src homology 2 domain–containing inositol 5 phosphatase 1 affects platelet responses and thrombus growth
... stroke. Src homology 2 domain–containing inositol 5-phosphatase 1 (SHIP1) is a 5-phosphatase capable of dephosphorylating the phosphatidylinositol 3,4,5-trisphosphate second messenger into ...
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SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome
... Probing arrays with 50 SH2 domains identifies a total of 529 array-positive interactions, together with 5949 array- negative and 1122 indeterminate SH2-ligand pairs. Array-positive interactions between SH2 domains and ...
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Phospholipase C-γ Contains Introns Shared by src Homology 2 Domains in Many Unrelated Proteins
... Figure 1.—(A) Phylogram of PLC-␥ homologs. The number of changes between each sequence is represented by the length of each branch, and the single best tree is shown. Numbers at each node indicate bootstrap values. (B) ...
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MicroRNA 155 Regulates Japanese Encephalitis Virus-Induced Inflammatory Response by Targeting Src Homology 2-Containing Inositol Phosphatase 1
... changes in JEV-induced neuroinflammation. SHIP1 knockdown by siRNA in BV-2 cells resulted in higher expression of inflamma- tory cytokines than in untreated cells. Further, cotransfection of BV-2 cells with ...
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Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly
... Age-related changes in T cell subset composition in- volve a reduced frequency/number of naïve T cells, in- creased number of memory T cells and increased proportion of CD28 - T cells, especially in the CD8 + sub- ...
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The Src homology-2 protein Shb modulates focal adhesion kinase signaling in a BCR-ABL myeloproliferative disorder causing accelerated progression of disease
... Bone marrow transduction and transplantation assay The pMIG-p210bcr/abl vector was used to produce retro- viruses directing the expression of BCR-ABL-GFP as de- scribed previously [47]. Balb/c Shb wild type or knockout ...
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Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy
... twins discordant for the MSA phenotype and CNV ana- lysis of 33 patients with MSA, including the MZ twins. The CNV beadchip analysis enabled direct measurement of the fluorescent intensity of each marker, which is sui- ...
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WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-angiogenic activities via Src-homology-2-domain- containing protein tyrosine phosphatase 1
... poor outcome. Modulating tumor-associated angiogenesis thus represents a promising strategy for the development of anti-cancer therapies [3, 4]. Angiogenesis is regulated by the balance between angiogenic and ...
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Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation
... Attenuation of cytokine signaling. Suppressor of cytokine signaling (SOCS) proteins are induced in response to cytokines and suppress signal transduction in two ways. Some SOCS proteins bind directly to janus kinases ...
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Rule-based Computational Modeling of Modular Signaling Protein Interactions
... Intracellular signal transduction pathways mediated by growth factor, cytokine, and hormone receptors control cell behavior, such as proliferation, survival, migration, and differentiation. Protein tyrosine kinases, ...
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T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells
... To better understand the function of TSAd, we used an algorithm for identification of SH2 domain-ligand pairs (SMALI) to identify possible binding partners for the TSAd phosphotyrosines. SMALI pointed to a pos- sible ...
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Original Article Down-regulation of MiR-365 as a novel indicator to assess the progression and metastasis of hepatocellular carcinoma
... protein Src homology 2 domain-con- taining 1 (SHC1) and apoptosis-promoting pro- tein BAX in pancreatic cancer cells [28], neuro- pilin 1 (NRP1) in malignant melanoma [37], thyroid transcription ...
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The role of SH3BP2 in the pathophysiology of cherubism
... SH3BP2: src homology 3 binding protein 2; PH: pleckstrin homology domain; PR: proline-rich domain; SH2: Src- homology 2 domain; Tyr: Tyrosine; Glu: Glutamic Acid; Asn: ...
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Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3
... Materials. All chemicals were obtained from Sigma-Aldrich with the follow- ing exceptions: penicillin and streptomycin (Whittaker MA Bioproducts); acetoxymethyl derivative of BCECF (Molecular Probes); TOPO TA Cloning ...
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On the Khovanov Homology of 2 and 3 Strand Braid Links
... Khovanov assigned a bigraded chain complex C i j , ( ) L to the oriented link diagram L whose differential was graded of bidegree ( ) 1, 0 and whose homotopy type depended only on the isotopy class of L. The bigraded ...
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Cycles in the chamber homology for SL(2,F)
... the homology group generator of S L ( 2, E ) to a generator of the K -theory group of C ∗ -algebra of S L ( 2, E ) by induction, it takes the effect of the base change map on the homology side ...
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The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Permits Replication of Terminal Repeat-Containing Plasmids
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is a lym- photropic gammaherpesvirus that is strongly associated with neoplasms of lymphoid (primary effusion lymphoma, multicen- tric Castleman’s disease) and endothelial ...
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HOMOLOGY MODELLING AND STRUCTURAL ANALYSIS OF HER 2
... The homology model of the Protein HER 2 was modeled using the Modeller software. The structure was predicted with the active site identification. The validation of the protein by Procheck and Rampage were ...
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