Stat3 Signaling Pathway
<p>Negative regulators of STAT3 signaling pathway in cancers</p>
... STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6, are important transducers of many cytokines and growth ...family, STAT3 is the most common, and is constitutively activated or overexpressed in ...
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Original Article Study on expression of IL-6/JAK/STAT3 signaling pathway in category IIIB prostatitis
... JAK/STAT3 signaling pathway in category IIIB ...JAK2/STAT3 signaling pathway blocker AG490 was given to rats with prostatitis every other day for one month), with 20 rats in each ...
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An inhibitor of cholesterol absorption displays anti-myeloma activity by targeting the JAK2-STAT3 signaling pathway
... We next measured the JAK2 activation level in MM cells. In both NCI-H929 and RPMI-8226 cells, SC09 inhibited JAK2 phosphorylation in a concentration- dependent manner in the presence of IL-6, the major stimulator of ...
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<p>STIP1 Regulates Proliferation and Migration of Lung Adenocarcinoma Through JAK2/STAT3 Signaling Pathway</p>
... and p-STAT3. Moreover, E-cadherin expression in the tumors of nude mice injected with STIP1 shRNA- transfected A549 cells was signi fi cantly higher (P<0.05, Figure 5F) than that of nude mice injected with ...
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LGR5 expression is controled by IKKα in basal cell carcinoma through activating STAT3 signaling pathway
... NF-κB pathway is dependent on ...of STAT3 signaling pathway during cancer ...of STAT3 signaling pathway contributes LGR5 expression in dependent of IKKα after the ...
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<p>Peri-tumor fibroblasts promote tumorigenesis and metastasis of hepatocellular carcinoma via Interleukin6/STAT3 signaling pathway</p>
... of STAT3 signaling in cancer cells is not ...transient STAT3 Tyr705 phosphorylation, while PTFs induce long-lasting STAT3 activation by continuously secreting ...and STAT3 ...
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BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway
... JAK/STAT3 signaling pathway reversed the stimulating role of BMX-ARHGAP in GC stem cells, effectively confirming the vital role of JAK/ STAT3 in BMX-ARHGAP ...JAK/STAT3 signaling ...
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S promotes cancer progression by activating JAK2/STAT3 signaling pathway in esophageal EC109 cells
... several signaling mol- ecules and ...of signaling pathways such as NF-κB, p38- MAPK/ERK1/2-COX-2 and HSP90 pathways ...JAK2/STAT3 signaling pathway is involved in various biological ...
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Original Article Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium
... IL-6/JAK/STAT3 signaling pathway in the pathogenesis of ...IL-6/JAK/STAT3 signaling pathway is active and may play an important role in the mechanisms of epithelial ...
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Original Article Circulating levels of molecules associated with JAK2/STAT3 signaling pathway in patients with acute pancreatitis
... JAK2/STAT3 pathway was activated in cerulein-induced AP rats’ pancreatic acinar ...JAK2/STAT3 signaling pathway in humans with acute pancreatitis (AP) is yet ...JAK2/STAT3 ...
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Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro
... Jak/Stat3 signaling pathway plays a vital role in regu- lating a number of pathways in tumorigenesis, including cell cycle progression, apoptosis, tumor angiogenesis, and tumor cell evasion of the ...
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Original Article Adiponectin mediates endothelial progenitor cell proliferation through mTOR-STAT3 signaling pathway
... mTOR/STAT3 signaling pathway is closely associated with cell proliferation, differentiation, and ...mTOR/STAT3 signaling pathway in adiponectin promoting EPCs proliferation by ...
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<p>DNMT3a promotes proliferation by activating the STAT3 signaling pathway and depressing apoptosis in pancreatic cancer</p>
... Results: DNMT3a was overexpressed and closely associated with poor outcomes of PDAC. DNMT3a knockdown restrained PDAC cell proliferation, induced cell cycle arrest and promoted apoptosis in vitro. Affymetrix GeneChip ...
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TMEM119 promotes gastric cancer cell migration and invasion through STAT3 signaling pathway
... (Figure 4A and B). Furthermore, 30 μ M AG490 treatment also significantly inhibited TMEM119 overexpression- induced increases in the p-STAT3, VEGF, MMP2, and MMP9 protein expression, but had no effect on the ...
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Original Article Downregulation of HSF2 inhibits inflammation in human intestinal epithelial cells by regulating IL-6/STAT3 signaling pathway
... Abstract: Heat shock transcription factor 2 (HSF2) is up-regulated in inflammatory bowel disease (IBD). However, the role and mechanism of HSF2 in human intestinal epithelial cells remains unclear. Human intestinal ...
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<p>Chrysin inhibits sphere formation in SMMC-7721 cells via modulation of SHP-1/STAT3 signaling pathway</p>
... Chrysin (5, 7-dihydroxy fl avone) is a natural fl avone widely found propolis and honey. Chrysin is well docu- mented to possess multiple biological activities, such as antioxidant, anti-in fl ammatory, especially anti- ...
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Original Article IL-6/STAT3 signaling pathway is activated in plasma cell mastitis
... IL-6/STAT3 signaling pathway, which is vital not only for the differentiation of plasma cells but also for survival of plasma cells and T lymphocytes, in 30 PCM cases, 10 acute mastitis cases and 10 ...
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Indirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathway
... on 2 different ovarian cancer cell lines. Our results showed that simple indirubin significantly inhibited cell viability and induced apoptosis in ovarian cancer cells. Detailed mecha- nism studies revealed that ...
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KIAA0247 suppresses the proliferation, angiogenesis and promote apoptosis of human glioma through inactivation of the AKT and Stat3 signaling pathway
... In the present study, we detected the expression of KIAA0247 in glioma specimens and glioma cell lines and validated the relationships between KIAA0247 expression and the clinicopathologic characteristics of glioma ...
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<p>FKBP14 Promotes The Proliferation And Migration Of Colon Carcinoma Cells Through Targeting IL-6/STAT3 Signaling Pathway</p>
... STAT3 in oeNC or oeFKBP14-transfected cells, respec- tively. As shown in Figure 4A, the proliferation rate of oeFKBP14-transfected cells was much higher than that in oeNC transfected cell, whereas this effect was ...
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