stellate cell
Original Article Inhibitory effects of dimethyl α-ketoglutarate in hepatic stellate cell activation
... Hepatic stellate cell (HSC) is a pivotal event in the initiation and progression of he- patic fibrosis and a major source of collagen ...hepatocyte cell lines were treated with DMKG at gradient ...
7
Unfolded protein response is an early, non-critical event during hepatic stellate cell activation.
... Hepatic stellate cells activate upon liver injury and help at restoring damaged tissue by producing extracellular matrix ...hepatic stellate cells in vitro and in vivo, prior to induction of classical ...
13
hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice
... In this study, we demonstrated that similar with the hUCMSCs, hUCMSC-EVs also have the capacity to alleviate S. japonicum-induced liver damage. More importantly, hUCMSC-EV-mediated amelioration of liver injury con- ...
11
Leucine-rich Repeats and Immunoglobulin 1 (LRIG1) Ameliorates Liver Fibrosis and Hepatic Stellate Cell Activation via Inhibiting Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P) Pathway
... Figure 1. l eucine-rich repeats and immunoglobulin 1 (LRIG1) expression in carbon tetrachloride (CCl4)-induced liver fibrosis and activated hepatic stellate cell (HSC) cells. Figure 1A. H & E staining, ...
12
Mitochondrial uncouplers inhibit hepatic stellate cell activation
... improve several pathologies. Heart ischemia/reperfusion detrimental effects can be ameliorated through pre- conditioning with mild uncoupling using chemical uncouplers while studies on mice show that uncoupler treatment ...
12
1 Rap1 regulates hepatic stellate cell migration through
... gtpase rap1 regulates cell migration through regulation of small gtpase rhoa activity in response to 405. transforming growth factor-beta1[r] ...
15
Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation
... NF-κB is a major ubiquitous transcription factor regu- lating the expression of genes involved in inflammatory responses. Sensitizing NF- κ B signaling via activation of IκB-kinase (IKK) complex and degradation of IκBα ...
11
Original Article Establishment and characterization of an immortalized rat hepatic stellate cell line
... critical length. Telomere shortening controls the entry of cells into senescence. Expression of the telomerase catalytic subunit stabilizes telomere length and extends the life span of various normal cells [26-28]. ...
11
The pancreatic stellate cell: a star on the rise in pancreatic diseases
... Pancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the pancreas that have exocrine function. PaSCs are regulated by autocrine and paracrine stimuli and share many features with ...
11
Geranylgeranylacetone attenuates fibrogenic activity and induces apoptosis in cultured human hepatic stellate cells and reduces liver fibrosis in carbon tetrachloride-treated mice
... LX2 cell apoptosis similarly in the HHSteCs ...in cell density of ...in stellate cell apoptosis [18], we first tested whether activation of JNK and p38 MAPK was involved in GGA-mediated ...
9
Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis
... In summary, our findings suggest that during extra- hepatic cholestasis in the mouse, liver injury, inflam- mation, markers of stellate cell activation, and eleva- tion of indices of hepatic fibrogenesis ...
9
Serum zinc levels in decompensated liver disease and its correlation with hepatic encepalopathy.
... of stellate cell , platelets and sinusoidal endothelium cell after chronic liver injury ...activate stellate cells to produce type 1 collagen formation , that excessive collagen deposition in ...
151
Effect of simvastatin on the transforming growth factor β1, fibroscan scores, and aspartate transaminase to platelet index ratio patients with Liver Cirrhosis
... hepatic stellate cell of the liver (Shirin et al, 2013), reducing hepatic stellate cell proliferation and decreased collagen deposition (Rombouts et al, 2003), inhibit steatosis, fibrosis and ...
7
Hepatic stellate cells in liver development, regeneration, and cancer
... hepatic stellate cell–HCC interactions in transgenic mouse models of HCC has been somewhat limited, with the notable exception of the PDGF-C transgenic mouse ...hepatic stellate cell ...
10
Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms
... The discovery of the molecular basis underlying the pathophysiological mechanisms of human disease is a step of paramount importance for the discovery of effective therapies. In this regard, while advanced liver fibrosis ...
19
Synaptic inhibition of cerebellar Purkinje cells
... Lugaro cell - Purkinje cell synaptic currents would be evoked by electrically stimulating in the areas in which Lugaro cells are ...basket cell or stellate cell inputs to Purkinje cells ...
312
Mucosal-Associated Invariant T cell in liver diseases
... Mucosal-associated invariant T cells (MAIT cells) are a new population of innate immune cells, which are abundant in the liver and play complex roles in various liver diseases. In this review, we summarize MAIT cells in ...
11
Liver fibrosis
... This cell type, first described by von Kupffer in 1876, undergoes a dramatic phenotypic activation in chronic liver diseases with the acquisition of fibrogenic properties ...the cell culture studies and led ...
11
Parasympathetic dysfunction and antiarrhythmic effect of vagal nerve stimulation following myocardial infarction
... intact cell bodies in the cardiac ganglia located in the basal regions of the heart that can repair injured ...whose cell bodies are anatomically ...
18
Mac the knife? Macrophages– the double edged sword of hepatic fibrosis
... Duffield and colleagues have gener- ated a transgenic mouse model in which macrophages can be selectively depleted in a regulated manner (4). Expression of a human version of a diptheria toxin recep- tor driven by the ...
5