Steroid sulfatase
Steroid Sulfatase Inhibitor Reduces Proliferation of Ishikawa Endometrial Cancer Cells in Co Culture Systems
... pathways, steroid sulfatase (STS) pathway and aromatase pathway are implicated in the crucial steps of estrogen ...of steroid-sulfotransferases and sulfonates estrogens to estrogen ...
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The Role of Steroid Sulfatase as a Prognostic Factor in Patients with Endometrial Cancer
... 16. Foster PA, Chander SK, Parsons MF, Newman SP, Woo LW, Potter BV, et al. Efficacy of three potent steroid sulfatase inhibitors: pre- clinical investigations for their use in the treatment of hormone- ...
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REVIEW ARTICLE Steroid sulfatase inhibitors: promising new therapy for breast cancer
... Manipulation of the hormone oestrogen has been used for decades to treat hormone-dependent breast cancer. Currently, aromatase inhibitors (AIs) are used as first-line therapy against early and metastatic breast cancer in ...
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Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X linked ichthyosis
... Patients with recessive X-linked ichthyosis, one of the inherited types of excessive stratum corneum cohesion, have deficient steroid sulfatase in fibroblasts grown from their dermis. Because of the expense ...
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Stratum corneum lipids in disorders of cornification Steroid sulfatase and cholesterol sulfate in normal desquamation and the pathogenesis of recessive X linked ichthyosis
... ichthyosis epidermis, enzyme levels were virtually undetectable at all levels. In normal human stratum corneum, up to 10 times more steroid sulfatase activity was present in purified peripheral membrane ...
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Polymorphisms of the steroid sulfatase (STS) gene are associated with attention deficit hyperactivity disorder and influence brain tissue mRNA expression
... Attention deficit hyperactivity disorder (ADHD) is one of the most heritable and prevalent childhood psychiatric disorders [Asherson, 2004], affecting an estimated 5% of school-aged chil- dren [Polanczyk et al., 2007]. ...
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GENETIC ANALYSIS OF MURINE ARYLSULFATASE C AND STEROID SULFATASE
... Male and female mice possessed similar 4MUS-, EIS- and DHEAS-sulfatase activities, and F1 males derived from recip- rocal crosses of the SWR/J (high activity) and A/J [r] ...
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IDENTIFICATION OF AN AUTOSOMAL LOCUS AFFECTING STEROID SULFATASE ACTIVITY AMONG INBRED STRAINS OF MICE
... curred in some recombinant inbred lines that were clearly A/J-like for overall activity, the presence or absence of this effect is not linked to the autosomal lo[r] ...
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EVIDENCE FOR X-LINKAGE OF STEROID SULFATASE IN THE MOUSE: STEROID SULFATASE LEVELS IN OOCYTES OF XX AND XO MICE
... The clinical abnor- malities characteristic of some human X chromosome aneuploidies did not seem compatible with the idea of the entire X chromosome in somatic cells bei[r] ...
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Impaired redox regulation of estrogen metabolizing proteins is important determinant of human breast cancers
... nascent sulfatase polypeptide in the endo- plasmic ...the sulfatase that directs the binding of the FGE [85]. Multiple sulfatase deficiency (MSD), a fatal autoso- mal recessive syndrome has been ...
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Endometrial Intracrinology: Oestrogens, Androgens and
... sulfotransferase and on steroid sulfatase expression in endometriosis tissue and stromal cells. Steroid sulfatase inhibitors for estrogen- and androgen- 767[r] ...
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Efficacy of Tacrolimus in Treating Nephrotic Syndrome Children
... point was the proportion of patients with complete or partial remission, on the basis of first-morning urine protein-to-creatinine ratios at 6 months. Complete or partial remission rates were higher in patients receiving ...
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Enzymatic degradation of urinary indoxyl sulfate by Providencia stuartii and Klebsiella pneumoniae causes the purple urine bag syndrome
... We conclude that PUBS results from the action by a bacterial enzyme a phosphatase with minor sulfatase activity, pI 6.4 on the IS in the urine of elderly catheterized patients with high [r] ...
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Characterization of Streptococcus milleri Group Isolates from Expectorated Sputum of Adult Patients with Cystic Fibrosis
... chondroitin sulfatase, DNase, proteases, and hydrogen peroxide; and PCR for the detection of the intermedilysin gene ...chondroitin sulfatase produc- ...
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A putative cortisol receptor in the rainbow trout erythrocyte: stress prevents starvation induced increases in specific binding of cortisol
... steroid-dependent phenomena, such a mechanism may be mediated via a specific cortisol receptor within the erythrocyte, or by interaction of cortisol with a membrane-located receptor (Gametchu et al. 1993; Grote et ...
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A RARE AND SEVERE ICHTHYOSIS OF NEONATES -HARLEQUIN ICHTHYOSIS
... .The known causative molecules underlying ichthyosis include ABCA12, lipoxygenase-3, 12R-lipoxygenase, CYP4F22, ichthyin and stero- id sulfatase, all of which are thought to be related to the intercellular lipid ...
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Relative safety of steroid sparing agents in frequently relapsing, steroid dependent and steroid resistant nephrotic syndrome in pediatric patients
... A multi-centre, observational prospective study was carried out in the out-patients department clinics of pediatric nephrology department in two tertiary care teaching hospital in Eastern India over a period of 24 ...
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Reactions of steroid epoxides
... The cooled reaction was extracted with ethyl acetate -ether 1:1 and the extracts were washed several times with water, dried over sodium sulphate and evaporated to give 3S-hydroxy-Dhomo-[r] ...
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Reactions of steroid epoxides
... Adsorption 4 of the isolated products on to alumina 100g in light petroleum followed by elution with light petroleuxa-benzene 1 2 afforded the 4p-methyl-.3o!,U..oactions .31% and eth... [r] ...
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REVERSION OF ARYL SULFATASELESS MUTANTS OF NEUROSPORA
... Properties of aryl sulfatase from revertants: The data in Table 1 do not reveal any substantial qualitative difference in Michaelis constants bstwcen wild-type and the revertan[r] ...
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