Sterol biosynthesis
Inhibition of Sterol Biosynthesis Reduces Tombusvirus Replication in Yeast and Plants
... FIG. 8. Role of SMO1 and SMO2 sterol biosynthesis genes in TBSV RNA replication in whole plants. (A) Accumulation of TBSV gRNA in the inoculated leaves of SMO1 knockdown N. benthamiana plants 3 days ...
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Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba
... required. Sterol biosynthesis has been effectively targeted in numerous fungi using azole compounds that inhibit the cytochrome P450 enzyme sterol ...major sterol of Acanthamoeba castellanii ...
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Chemical Synthesis of Ring C oxygenated Derivatives of Cholesterol and their Inhibition of Sterol Biosynthesis
... Chemical synthesis of oxygenated derivatives of cholesterol and lanosterol, have been shown to produce oxysterols with significant activity as inhibitors of 3-hydroxy-3- methylglutaryl (HMG) CoA reductase, a key ...
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Cumulative Mutations Affecting Sterol Biosynthesis in the Yeast Saccharomyces cerevisiae Result in Synthetic Lethality That Is Suppressed by Alterations in Sphingolipid Profiles
... on sterol biosynthesis. When sterol levels are reduced due to the addition of Lovastatin, the expression of ERG2 and ERG3 substantially ...to sterol depletion binding of the repressor is ...
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Endoplasmic Reticulum-Associated Degradation Is Required for Cold Adaptation and Regulation of Sterol Biosynthesis in the Yeast Saccharomyces cerevisiae
... the sterol biosynthetic enzyme, 3-hydroxy- 3-methylglutaryl coenzyme A reductase ...The sterol metabolite profile of ubc7 ⌬ cells was altered relative to that of wild-type ...Since sterol levels are ...
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7 Dehydrocholesterol–dependent proteolysis of HMG CoA reductase suppresses sterol biosynthesis in a mouse model of Smith Lemli Opitz/RSH syndrome
... total sterol levels, and 30- to 40-fold elevated concentrations of ...reduced sterol concentrations in Dhcr7 –/– mice, mRNA levels for 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the ...
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Chemical Synthesis of Ring C oxygenated Derivatives of Cholesterol and their Inhibition of Sterol Biosynthesis
... In view of biological importance of Schiff base derived from the condensation of ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate with salicylaldehyde, its [r] ...
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Evidence that the intra amoebal Legionella drancourtii acquired a sterol reductase gene from eukaryotes
... the sterol biosynthesis (Figure 5) ...the sterol delta-7 reductase-encoding gene, while ...in sterol biosynthesis and as a consequence can synthesize sterols [29,30], however, only ...
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Using PCR to Compare the Expression of CDR1, CDR2, and MDR1 in Candida Albicans Isolates Resistant and Susceptible to Fluconazole
... Background and Objectives: More Candida albicans strains are reported resistant to fluconazole in patients with AIDS, cancer and organ recipients. Fluconazole resistance can be attributed to changes in pathways of ...
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Survival strategies of a sterol auxotroph
... are sterol auxotrophs, requiring dietary sources of sterols for their development (Hobson, ...membrane sterol levels in the endoplasmic reticulum (ER) via the sterol regulatory element-binding ...
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The Cytochrome P450 Complement (CYPome) of Leishmania Leads to the Discovery of a Plant like Cytochrome P450 Sub family CYP710C1 Gene
... The presence of stigmasterol, ergosterol and their corresponding isoforms in L. donovani clearly indicates that Leishmania has acquired both the fungus and plant pathways for sterol biosynthesis. ...
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The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes
... and sterol metabolism and cholesterol and sterol biosynthesis, and expression of the majority of genes in these categories was down-regulated across iPSC-derived cardiomyo- cytes treated with ...
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Synthesis of HMG-CoA Reductase Inhibitor Lanost-8-en-3β-ol-7, 11-dione through Oxidation of 3β-acetoxylanost-8-en-7, 11-dione with Pyridinium Chlorochromate
... As a class of compounds, oxysterols can be defined as sterols bearing second oxygen containing functional group, in addition to that at carbon-3, and having an iso-octyl or modified iso-octyl side chain. A number of ...
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LEISHMANIASIS: Current Treatment Strategies and Future Opportunities
... polyamine biosynthesis that was also originally developed as an anticancer agent but is now used for the treatment of stage 2 Trypanosoma brucei gambiense ...
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Cryogenian evolution of stigmasteroid biosynthesis
... extended sterol biosynthesis in bacteria (3), steranes preserved in sediments and ancient rocks have been frequently used as fossil biomarkers diagnostic of ancient ...
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The reactivity of desmosterol and other shellfish and xanthomatosis associated sterols in the macrophage sterol esterification reaction
... xanthomatosis (CTX). We first show that the J774 macrophage, a foam cell model with a hyperactive ACAT pathway, synthesizes desmosterol instead of cholesterol and that both endogenous and exogenous desmosterol are ...
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Sterol Binding by the Tombusviral Replication Proteins Is Essential for Replication in Yeast and Plants
... with sterol-enriched DRMs suggests that the tombusvirus replicase is likely associated with lipid microdomains in subcellular ...high sterol content in DRMs might not affect tombusvirus RdRp ...
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Diverse protein regulations on PHA formation in Ralstonia eutropha on short chain organic acids
... acetate-treated medium enhanced glutathione bio- synthesis by up-regulation of S-adenosylmethionine (SAM) synthetase catalyzing SAM formation from methionine and ATP (Table 1). SAM is an important methyl donor for ...
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Sex difference in human mevalonate metabolism
... Two pathways of mevalonate metabolism have been demonstrated: the major (sterol) pathway leads to cholesterol synthesis, whereas the second shunts mevalonate away from sterol production and ultimately ...
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The biosynthesis of porphyrins and haems
... 1 The biosynthesis of porphyrins and haems* 3 3* Glycine in haem biosynthesis* 8 4* Acetate in haem biosynthesis* 10 5* The citric acid cycle and haem biosynthesis* 6* 6-aminolaevulic ac[r] ...
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