sterol regulatory
The pattern of development for gene expression of sterol regulatory element binding transcription factor 1 in pigs
... (sterol regulatory element-binding tran- scription factor 1) is a member of the basic he- lix-loop-helix leucine zipper (bHLH-LZ) family of transcription ...termed sterol regulatory ...
5
Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress
... (10). Sterol regulatory element binding proteins (SREBPs) are endoplasmic reticulum (ER) membrane-bound transcription factors that activate genes encoding the enzymes that regulate the synthesis of ...
9
Conservation of the Sterol Regulatory Element-Binding Protein Pathway and Its Pathobiological Importance in Cryptococcus neoformans
... mammalian sterol regulatory element-binding protein (SREBP) homolog, Sre1, is important for adap- tation and growth of Cryptococcus neoformans in the mouse brain, where oxygen concentration and nutritional ...
10
FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c
... metabolism. Sterol regulatory element-binding protein 1c (SREBP1c) luciferase reporter gene plasmid was co-transfected into HepG2 cells with FoxO3 overexpression ...
12
Effects of sterol regulatory element-binding protein (SREBP) in chickens
... Sterol regulatory element binding proteins (SREBP) are basic helix-loop-helix-leucine zipper (bHLH-Zip) tran- scription factors that play an important role in control- ling genes involved in the ...
7
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
... the sterol regulatory element binding pro- teins (SREBPs), a small family of lipogenic transcription fac- ...intracellular sterol concentrations are low, SREBP/SCAP complexes translocate to the Golgi ...
21
Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1
... nisms. Sterol regulatory element binding proteins (SREBPs) are the principal regulators to maintain the proper levels of intracel- lular lipids (15); their biology and means of activation, described below, ...
8
Sterol Regulatory Element-Binding Protein 2 Couples HIV-1 Transcription to Cholesterol Homeostasis and T Cell Activation
... Cholesterol plays an essential role in the life cycle of several enveloped viruses. Many of these viruses manipulate host cholesterol metabolism to facilitate their replication. HIV-1 infection of CD4 ⴙ T cells activates ...
11
Sterol regulatory element binding protein 1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
... endometrial Sterol Regulatory Element Binding Protein-1 gene (SREBP1) expression in PCOS and EC endometrium, and to correlate endometrial SREBP1 expression with serum lipid ...
15
Sterol Regulatory Element Binding Proteins; Central Metabolic Regulators of Natural Killer Cells
... In many cell types, the activity of sterol regulatory element binding proteins (SREBP) is induced downstream of mTORC1 activation (Porstmann et al. 2008). SREBP transcription factors are a group of ...
256
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
... to sterol regulatory elements in the promoters of genes encoding the LDL receptor and several enzymes in the choles- terol biosynthetic pathway, including 3-hydroxy-3-methylglu- taryl coenzyme A (HMG CoA) ...
10
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein 1 in human and mouse organs and cultured cells
... mRNA-encoding sterol regulatory ele- ment binding protein-1 (SREBP-1) exists in two forms, des- ignated 1a and ...by regulatory regions that respond differentially to organ-specific and metabolic ...
9
Influences of sterol regulatory element binding protein-1c silencing on glucose production in HepG2 cells treated with free fatty acid
... is a multifunctional enzyme produced by many tissues, including adipose tissue, cardiac and skeletal muscle, islets, and macrophages, but LPL is in normally not made in the adult liver [17]. Sterol ...
12
Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function
... The best characterized role for SREBP is its function in lipid synthesis. When sterol levels within the cell are low SREBP is activated to restore lipid biosynthesis and lipid homeostasis. Hence, we decided to ...
261
Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
... To date, in-depth characterizations of fungal SREBPs have been performed for S. pombe, C. neoformans, and A. fumigatus. However, many fungal species contain putative SREBPs and components of the SREBP pathway, including ...
8
Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity
... [125]. Sterol regulatory element-binding protein 1 (SREBP1) is a membrane-bound TFs that belongs to a family of basic helix-loop-helix-leucine zip- per (bHLHLZ) TFs ...to sterol regulatory ...
14
Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue
... Furthermore, sterol regulatory element binding protein 1(SREBP-1), peroxisome proliferator-activated receptor g (PPARg) and adipose fatty acids-binding pro- tein (A-FABP, also known as FABP4), have recently ...
13
AMPK: A POTENT TARGET FOR TREATING OBESITY
... as Sterol regulatory element-binding protein 1(SREBP1), CCAAT-enhancer- binding proteins(C/EBPα) and Peroxisome proliferator-activated receptor gamma (PPARγ) which strictly regulates adipocyte ...
13
Plastic Surgery Update on the Biology of Fat Cells and Adipose Derived Stem Cells for Fat Grafting
... OALibJ | DOI:10.4236/oalib.1101505 6 June 2015 | Volume 2 | e1505 Figure 1. The proliferation and differentiation of embryonic stem cells to mature white adipocytes require a complex inte- gration of changes in the ...
26
Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells
... The deregulation of lipid metabolism is a hallmark of tumor cells, and elevated lipogenesis has been reported in prostate cancer. Metformin, a drug commonly prescribed for type II diabetes, displays antitumor properties. ...
10