sterol regulatory element
Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death
... by sterol regulatory element-binding transcription factors (SREBFs), which are transcription factors that modulate the transcription of genes involved in lipid and choles- terol ...In ...
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Sterol regulatory element binding protein 1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
... endometrial Sterol Regulatory Element Binding Protein-1 gene (SREBP1) expression in PCOS and EC endometrium, and to correlate endometrial SREBP1 expression with serum lipid ...
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Effects of sterol regulatory element-binding protein (SREBP) in chickens
... Sterol regulatory element binding proteins (SREBP) are basic helix-loop-helix-leucine zipper (bHLH-Zip) tran- scription factors that play an important role in control- ling genes involved in the ...
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Conservation of the Sterol Regulatory Element-Binding Protein Pathway and Its Pathobiological Importance in Cryptococcus neoformans
... mammalian sterol regulatory element-binding protein (SREBP) homolog, Sre1, is important for adap- tation and growth of Cryptococcus neoformans in the mouse brain, where oxygen concentration and ...
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FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c
... metabolism. Sterol regulatory element-binding protein 1c (SREBP1c) luciferase reporter gene plasmid was co-transfected into HepG2 cells with FoxO3 overexpression ...
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Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
... the sterol regulatory element binding pro- teins (SREBPs), a small family of lipogenic transcription fac- ...intracellular sterol concentrations are low, SREBP/SCAP complexes translocate to ...
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Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1
... nisms. Sterol regulatory element binding proteins (SREBPs) are the principal regulators to maintain the proper levels of intracel- lular lipids (15); their biology and means of activation, described ...
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Sterol Regulatory Element Binding Proteins; Central Metabolic Regulators of Natural Killer Cells
... In many cell types, the activity of sterol regulatory element binding proteins (SREBP) is induced downstream of mTORC1 activation (Porstmann et al. 2008). SREBP transcription factors are a group of ...
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Sterol Regulatory Element-Binding Protein 2 Couples HIV-1 Transcription to Cholesterol Homeostasis and T Cell Activation
... Cholesterol plays an essential role in the life cycle of several enveloped viruses. Many of these viruses manipulate host cholesterol metabolism to facilitate their replication. HIV-1 infection of CD4 ⴙ T cells activates ...
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Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress
... (10). Sterol regulatory element binding proteins (SREBPs) are endoplasmic reticulum (ER) membrane-bound transcription factors that activate genes encoding the enzymes that regulate the synthesis of ...
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The pattern of development for gene expression of sterol regulatory element binding transcription factor 1 in pigs
... (sterol regulatory element-binding tran- scription factor 1) is a member of the basic he- lix-loop-helix leucine zipper (bHLH-LZ) family of transcription ...termed sterol regulatory ...
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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein 1 in human and mouse organs and cultured cells
... The 5' end of the mRNA-encoding sterol regulatory element binding protein-1 (SREBP-1) exists in two forms, designated 1a and 1c. The divergence results from the use of two transcription start sites ...
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p38 Mitogen-Activated Protein Kinase and Liver X Receptor-α Mediate the Leptin Effect on Sterol Regulatory Element Binding Protein-1c Expression in Hepatic Stellate Cells
... fibrosis. Sterol regulatory element binding protein (SREBP)-1c, a critical transcription factor for lipid synthesis and adipocyte differ- entiation, functions as a key transcription factor in ...
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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element binding protein 2
... of sterol regulatory element-binding protein-2 (SREBP-2) in liver and adipose ...minal regulatory domains, and it is therefore not susceptible to negative regulation by ...
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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
... to sterol regulatory elements in the promoters of genes encoding the LDL receptor and several enzymes in the choles- terol biosynthetic pathway, including 3-hydroxy-3-methylglu- taryl coenzyme A (HMG CoA) ...
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Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function
... The data reveal that NK cells undergo dramatic metabolic reprogramming upon activation, upregulating rates of glucose uptake and glycolysis, and that mTORC1 activity is essential for att[r] ...
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Influences of sterol regulatory element binding protein-1c silencing on glucose production in HepG2 cells treated with free fatty acid
... is a multifunctional enzyme produced by many tissues, including adipose tissue, cardiac and skeletal muscle, islets, and macrophages, but LPL is in normally not made in the adult liver [17]. Sterol ...
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Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
... To date, in-depth characterizations of fungal SREBPs have been performed for S. pombe, C. neoformans, and A. fumigatus. However, many fungal species contain putative SREBPs and components of the SREBP pathway, including ...
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Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity
... common regulatory patterns that should be over-represented in the CERTL, we took advantage of several publicly available bioinfor- matics ...E47, Sterol Regulatory Element Binding Protein 1 ...
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An in silico study on the interaction between RU486, a glucocorticoid antagonist and some regulatory proteins of lipid metabolism
... (PPARγ), sterol regulatory element-binding protein 1c (SREBP-1c), cluster differentiation 36 (CD36), acetyl-CoA Carboxylase (ACC), FASN, stearoyl-CoA desaturase-1 (SCD-1), liver X receptor β (LXRβ) ...
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