Sterol regulatory element binding protein
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element binding protein 2
... of sterol regulatory element-binding protein-2 (SREBP-2) in liver and adipose ...encoded protein lacks the membrane-binding and COOH-terminal regulatory domains, ...
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Sterol Regulatory Element-Binding Protein 2 Couples HIV-1 Transcription to Cholesterol Homeostasis and T Cell Activation
... the sterol regulatory element-binding protein 2 (SREBP2) transcriptional program, which includes genes involved in cholesterol ...
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Activation of sterol regulatory element binding protein 1 (SREBP1) mediated lipogenesis by the Epstein Barr virus encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma
... membrane protein 1 (LMP1), which is commonly expressed in NPC, engages multiple signaling pathways that promote cell growth, transformation, and metabolic ...of sterol regulatory ...
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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein 1 in human and mouse organs and cultured cells
... The 5' end of the mRNA-encoding sterol regulatory element binding protein-1 (SREBP-1) exists in two forms, designated 1a and 1c. The divergence results from the use of two transcription ...
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p38 Mitogen-Activated Protein Kinase and Liver X Receptor-α Mediate the Leptin Effect on Sterol Regulatory Element Binding Protein-1c Expression in Hepatic Stellate Cells
... fibrosis. Sterol regulatory element binding protein (SREBP)-1c, a critical transcription factor for lipid synthesis and adipocyte differ- entiation, functions as a key transcription ...
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Sterol regulatory element binding protein 1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
... endometrial Sterol Regulatory Element Binding Protein-1 gene (SREBP1) expression in PCOS and EC endometrium, and to correlate endometrial SREBP1 expression with serum lipid ...
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Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1
... SREBP, sterol regulatory element binding protein; SCAP, SREBP cleavage-activation protein; INSIG-1, insulin-induced gene 1; ER, endoplasmic ...
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Conservation of the Sterol Regulatory Element-Binding Protein Pathway and Its Pathobiological Importance in Cryptococcus neoformans
... mammalian sterol regulatory element-binding protein (SREBP) homolog, Sre1, is important for adap- tation and growth of Cryptococcus neoformans in the mouse brain, where oxygen ...
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Influences of sterol regulatory element binding protein-1c silencing on glucose production in HepG2 cells treated with free fatty acid
... Glucose production was assayed after SREBP-1c silencing for 24 h, which was the period of maximal SREBP-1c silencing (Fig. 2). Cells were washed three times with phosphate-buffered saline (PBS) to remove glucose, then ...
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Effects of sterol regulatory element-binding protein (SREBP) in chickens
... reverse ch5’AS primer. The RT-PCR was followed by a nested PCR by means of the human forward hu5’UTRnS primer corresponding to nucleotides 62 to 84 of the 5’ UTR region and the reverse chicken ch5’nAS primer. The total ...
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Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
... that protein and lipid biosynthesis downstream of the Akt/mTORC1 pathway might be intricately ...Akt-dependent protein synthesis and caused alterations in cellular lipid composition characterized by a ...
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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
... to sterol regulatory elements in the promoters of genes encoding the LDL receptor and several enzymes in the choles- terol biosynthetic pathway, including 3-hydroxy-3-methylglu- taryl coenzyme A (HMG CoA) ...
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FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c
... or binding to en- hancers: FoxO3 recruits Sirt6 to the proximal promoter region of the proprotein convertase subtilisin/kexin type 9 gene to regulate cholesterol homeostasis [32]; FoxO3 binds to enhancers and ...
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Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function
... Glycolysis provides the biosynthetic precursors that are essential for the synthesis of proteins, nucleic acids and lipids (Hume et al., 1978). Pro- inflammatory immune cells have the ability to engage in robust cellular ...
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Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue
... Furthermore, sterol regulatory element binding protein 1(SREBP-1), peroxisome proliferator-activated receptor g (PPARg) and adipose fatty acids-binding pro- tein (A-FABP, also ...
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Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells
... The deregulation of lipid metabolism is a hallmark of tumor cells, and elevated lipogenesis has been reported in prostate cancer. Metformin, a drug commonly prescribed for type II diabetes, displays antitumor properties. ...
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The pattern of development for gene expression of sterol regulatory element binding transcription factor 1 in pigs
... (sterol regulatory element-binding tran- scription factor 1) is a member of the basic he- lix-loop-helix leucine zipper (bHLH-LZ) family of transcription ...termed sterol ...
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AMPK: A POTENT TARGET FOR TREATING OBESITY
... AMPK mediates a number of physiological functions like carbohydrate and lipid metabolism, growth and differentiation, ion transport and blood flow, appetite regulation etc by regulating the genes (shown in ...
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Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity
... [125]. Sterol regulatory element-binding protein 1 (SREBP1) is a membrane-bound TFs that belongs to a family of basic helix-loop-helix-leucine zip- per (bHLHLZ) TFs ...to sterol ...
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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
... 1/sterol regulatory element binding protein (SREBP) 1, a basic-helix-loop-helix protein that has a dual DNA-binding specificity, is reduced dramatically upon fasting and ...
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