sterol regulatory element binding protein 1 (SREBP1)
Activation of sterol regulatory element binding protein 1 (SREBP1) mediated lipogenesis by the Epstein Barr virus encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma
... membrane protein 1 (LMP1), which is commonly expressed in NPC, engages multiple signaling pathways that promote cell growth, transformation, and metabolic ...of sterol regulatory ...
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Sterol regulatory element binding protein 1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
... endometrial Sterol Regulatory Element Binding Protein-1 gene (SREBP1) expression in PCOS and EC endometrium, and to correlate endometrial SREBP1 expression with ...
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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein 1 in human and mouse organs and cultured cells
... The 5' end of the mRNA-encoding sterol regulatory element binding protein-1 (SREBP-1) exists in two forms, designated 1a and 1c. The divergence results from the use of two ...
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Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1
... for 1 h, followed by incubation with 10 g/ml of anti-SREBP1 antibody (IgG-2A4; BD FIG 1 (A) The glycolytic, glutaminolytic, fatty acid, triglyceride, and cholesterol biosynthetic pathways discussed ...
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Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity
... [125]. Sterol regulatory element-binding protein 1 (SREBP1) is a membrane-bound TFs that belongs to a family of basic helix-loop-helix-leucine zip- per (bHLHLZ) TFs ...
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The pattern of development for gene expression of sterol regulatory element binding transcription factor 1 in pigs
... (sterol regulatory element-binding tran- scription factor 1) is a member of the basic he- lix-loop-helix leucine zipper (bHLH-LZ) family of transcription ...termed sterol ...
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Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
... mature SREBP1 in response to Akt activation ...metabolic regulatory network downstream of mTORC1 in cells deficient for the tuberous sclerosis complex 1 or 2 genes (TSC1 or TSC2) ...of SREBP1 ...
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Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue
... palmitoyltransferase 1 (CPT-1) are rate limiting enzymes in catabolism, responsible for hydrolysis of triglycerides and importing esters of fatty acids to mitochondria for b-oxidation ...Furthermore, ...
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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
... (ADD) 1/sterol regulatory element binding protein (SREBP) 1, a basic-helix-loop-helix protein that has a dual DNA-binding specificity, is reduced ...
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Effects of sterol regulatory element-binding protein (SREBP) in chickens
... forecasted protein sequences ...Chicken SREBP1 mRNA is detected in most tissues, and expressed highly in the liver and uropygial gland, both of which have high lipid synthetic activity; also Chicken SREBP2 ...
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Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress
... FAS protein in HCV-infected cells, cel- lular lysates from cells infected with HCV were subjected to SDS-PAGE followed by Western blot ...(bar 1) and JS-15 (containing mutated SRE binding sites) ...
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Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function
... activating protein) is an integral membrane protein located in the endoplasmic reticulum (ER) and bound to ...exon 1 of the SCAP gene (Matsuda et ...
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An in silico study on the interaction between RU486, a glucocorticoid antagonist and some regulatory proteins of lipid metabolism
... (PPARγ), sterol regulatory element-binding protein 1c (SREBP-1c), cluster differentiation 36 (CD36), acetyl-CoA Carboxylase (ACC), FASN, stearoyl-CoA desaturase-1 (SCD-1), ...
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FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c
... vations: 1) transfection with Foxo3 siRNA in HepG2 cells lowered the protein and mRNA levels of SREBP1c; 2) adenovirus or plasmid mediated overexpression of FoxO3 resulted in increased expression of ...
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Influences of sterol regulatory element binding protein-1c silencing on glucose production in HepG2 cells treated with free fatty acid
... Cells in 6-well plates were immediately washed with ice-cold PBS following treatment and lysed with 500 μL Tri- zol reagent (Invitrogen). Total RNA was extracted, Reverse transcription was performed with 460 ng total RNA ...
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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
... to 1 1 of the hamster HMG CoA synthase promoter region (26) and bp 2 308 to 2 61 of the human LDL receptor promoter region (27), respectively, and insertion of the PCR products into pGL2- Basic (Promega), a ...
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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element binding protein 2
... In the Northern blotting experiment of Fig. 3, the livers of the line B mice contained about threefold more transgene SREBP-2 mRNA than the livers of the line A mice (Fig. 3, up- per left panel ). A similar trend was ...
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p38 Mitogen-Activated Protein Kinase and Liver X Receptor-α Mediate the Leptin Effect on Sterol Regulatory Element Binding Protein-1c Expression in Hepatic Stellate Cells
... and 1 μmol/L insulin) with ...α protein level and activity and LXR α binding to SREBP-1c promoter and the effect of leptin-induced inhibition of SREBP-1c ex- pression on alpha1(I) collagen ...
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Conservation of the Sterol Regulatory Element-Binding Protein Pathway and Its Pathobiological Importance in Cryptococcus neoformans
... to 1% oxygen and 5% CO 2 at 37°C. Al- though 1% oxygen conditions rarely occur in a healthy human body, we chose such a stringent oxygen condition as our screening criterion in order to exclude mutants ...
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Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
... domain-containing protein with the unique tyrosine residue in the DNA-binding domain (Table ...This protein, called Cph2, was identified in a genetic screen as a regulator of the yeast-to-hypha ...
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