Still’s disease
Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker
... adult-onset Still ’ s disease; BSA: bovine serum albumin; EAE: experimental autoimmune encephalomyelitis; GAPDH: glyceraldehydes-3- phosphate dehydrogenase; GLK: germinal center kinase-like kinase; ...
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Comparative study of Interleukin-18 (IL-18) serum levels in adult onset Still’s disease (AOSD) and systemic onset juvenile idiopathic arthritis (sJIA) and its use as a biomarker for diagnosis and evaluation of disease activity
... onset Still ’ s disease (AOSD) and systemic onset ju- venile idiopathic arthritis (sJIA) are both considered to be multifactorial autoinflammatory diseases with a pre- dominant activation of the ...
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The Hyperferritinemic Syndrome: macrophage activation syndrome, Still’s disease, septic shock and catastrophic antiphospholipid syndrome
... An acquired form of HLH that occurs in autoimmune diseases is called MAS, and is most frequently seen complicating systemic juvenile idiopathic arthritis, but this syndrome has been increasingly reported in patients with ...
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Practice and consensus-based strategies in diagnosing and managing systemic juvenile idiopathic arthritis in Germany
... Even though SJIA is currently classified according to the ILAR classification criteria for JIA, its pathogenesis, clinical characteristics and response to therapy are very different from other categories of JIA, and SJIA ...
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Tolerance and efficacy of off-label anti-interleukin-1 treatments in France: a nationwide survey
... adult-onset Still ’ s disease (AOSD) (35), gout (28), systemic juvenile idiopathic arthritis (27), cryopyrin-associated periodic syndrome (CAPS) (21), familial Mediterranean fever (14) and mevalonate ...
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Biological therapy of traditional therapy-resistant adult-onset Still’s disease: an evidence-based review
... Still’s disease, AOSD, bio- logical therapy, biologics, TNF- α inhibitor, IL-1 inhibitor, IL-6 inhibitor, IL-18 inhibitor, infliximab, etanercept, adalimumab, golimumab, anakinra, canakinumab, tocilizumab, ...
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Application of the Yamaguchi criteria for classification of “suspected” systemic juvenile idiopathic arthritis (sJIA)
... Still’s disease (as defined by the Taplow group criteria) was published in ...any disease had unique features and were labeled as “benign systemic disease” due to the fact that all had fever with ...
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Whipple’s disease diagnosed during anti tumor necrosis factor alpha treatment: two case reports and review of the literature
... joint disease, TNF-α antagonist therapy, days with TNF-α antagonist therapy before WD was diagnosed, symptoms related to WD, organs affected by WD, inves- tigations for diagnosing WD, treatment and outcome of WD ...
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Treatment of adult-onset Still’s disease: a review
... Adult-onset Still’s disease is a complex disease with a polymorphic clinical presentation. In some cases, AOSD is as simple as a unique flare easily cured by NSAIDs or short-course corticosteroid therapy. ...
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Adult-onset Still's disease: current challenges and future prospects
... Still’s disease (AOSD) – a multi-systemic inflammatory condition characterized by high fevers, polyarthritis, an evanescent rash, and pharyngitis – has been a challenging condition to diagnose expediently and ...
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Adult-onset Still disease: a rare disorder with a potentially fatal outcome
... Still’s disease (AOSD) is a rare systemic inflammatory disorder of unknown aetiology character- ized by a typical triad of symptoms including daily high spiking fever, evanescent salmon-pink rash and arthri- ...
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The Why of Sporadic Motor Neuron Disease - Many Factors, still a Mystery?
... only small numbers of patients, confirmation of results by independent studies is largely lacking and, studying multiple endogenous and environmental factors in parallel, the significance of the observations is lost when ...
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Entry of poliovirus into cells does not require a low-pH step.
... However, a direct action of these agents in the initial steps of virus infection is still uncertain, because chloroquine was still active in the inhibition of foot-and-mouth disease viru[r] ...
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Moderating effects of sex on the impact of diagnosis and amyloid positivity on verbal memory and hippocampal volume
... Some inconsistencies in the extant literature relate to disease stage included and concurrent versus longitu- dinal assessment of outcomes. For example, on one hand, although A + may be detectable in NC, it may ...
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Older patients are still under-represented in clinical trials of Alzheimer’s disease
... ’ s disease and other conditions that overwhelmingly affect old people, the inclusion of representative samples of patients in trials testing in- novative pharmacological approaches and new drugs should be ...
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Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer's disease
... The pathogenesis of AD is complex and there is a strong case for integrating information across multiple physio- logical levels, from molecular profiling (metabolomics, lipidomics, proteomics and transcriptomics) and ...
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Care of the injured worldwide: trauma still the neglected disease of modern society
... to disease or disabil- ity), are due to conditions that could be adequately treated with surgery ...cal disease are 27 per 1,000, and this burden is felt dispro- portionally by ...
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Disease-modifying drugs in Alzheimer's disease
... the disease. In the last decade, despite a number of promising disease-modifying compounds having been developed, none has ever succeeded in Phase III ...potentially disease-modifying ...
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MAP4K3/GLK in autoimmune disease, cancer and aging
... GLK overexpression is a therapeutic target for auto- immune diseases and cancer recurrence. Inhibition of GLK may be useful for treating cancer and autoimmune disease patients. An analogue of crizotinib (compound ...
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Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies
... As expected, decline in mild AD was more pro- nounced than in MCI but still modest. ADAS-Cog 11 scores of subjects with mild AD declined 3.5 points over 12 months in our analysis. This seems to correspond to the ...
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