Stratum Corneum (SC)
Chemical Enhancer: A Simplistic Way to Modulate Barrier Function of the Stratum Corneum
... Human skin could be a prime target to deliver drugs into the human body as it is the largest organ of human body. However, the main challenge of delivering drug into the skin is the stratum corneum (SC), ...
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Presence and persistence of a highly ordered lipid phase state in the avian stratum corneum
... To survive high temperatures in a terrestrial environment, animals must effectively balance evaporative heat loss and water conservation. In passerine birds, cutaneous water loss (CWL) is the primary avenue of water loss ...
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Lipid composition of the stratum corneum and cutaneous water loss in birds along an aridity gradient
... Among endotherms, birds have the highest mass-specific rates of total evaporative water loss (Williams and Tieleman, 2005), accounting for five times the water lost through urine and feces in many small bird species ...
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Altered lipid properties of the stratum corneum in Canine Atopic Dermatitis
... Skin barrier disruption plays a role in the pathogenesis of atopic dermatitis (AD) in humans. However, little is known about skin barrier (dys-) function in Canine Atopic Dermatitis. The properties of lipids located in ...
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Phenotypic flexibility in cutaneous water loss and lipids of the stratum corneum
... In summary, the proportion of ceramides and free fatty acids in the stratum corneum in larks affects the rate of water loss through the skin. The lower CWL and TEWL rates found in species of larks (Williams ...
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Filaggrin loss of function mutations are associated with enhanced expression of IL 1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency
... the stratum corneum (SC), altering the ac- tivity of the multiple serine proteases and 2 ceramide-generating enzymes that regulate homeostasis of the ...
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The physics of stratum corneum lipid membranes
... The Stratum Corneum (SC), the outermost layer of skin, comprises rigid corneocytes (keratin filled dead cells) in a specialized lipid matrix. The continuous lipid matrix provides the main barrier against ...
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Stratum corneum lipids in disorders of cornification: increased cholesterol sulfate content of stratum corneum in recessive x linked ichthyosis
... Since the quantity of cholesterol sulfate in RXLI scale >1% of total stratum corneum weight far exceeds the levels detected in RXLI plasma, it is likely that the observed accumulation of[r] ...
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Clinical Evaluation of Moisturizers with Physiological Analysis of Stratum Corneum TARC and TSLP
... The studied skin condition was soothed with continuous treatment. We believe that the 8-week moisturizer appli- cation improved the skin conditions of the patients with atopic dermatitis and dry skin. The skin ...
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From observational to analytical morphology of the stratum corneum: progress avoiding hazardous animal and human testings
... Results: With any of the analytical evaluations, SACD and CSSS provide specific salient infor- mation that is useful in the field of cosmetology. In particular, both methods appear valuable and complementary in assessing ...
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TEM Assessments of the Restructuring Effects of an Emollient Cream on the stratum corneum
... Skin barrier properties depend on several cellular and intercellular parameters. Epidermal cells are continuously renewed. Keratinocytes of the stratum granulosum be- come progressively cornified cells densely ...
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The role of the stratum corneum lipids and enzymes in skin condition
... the stratum corneum lipids appear to be synthesised during barrier repair as highlighted using inhibitors to the key rate limiting enzymes (Feingold ...
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Stratum corneum lipid liposome-encapsulated panomycocin: preparation, characterization, and the determination of antimycotic efficacy against <em>Candida</em> spp. isolated from patients with vulvovaginitis in an in vitro human vaginal epithelium tissue model
... loaded stratum corneum lipid liposomes (SCLLs), characterization of the SCLLs, and determina- tion of antimycotic efficacy of the formulation against Candida albicans and Candida glabrata clinical vaginal ...
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A population-based study of the stratum corneum moisture
... tion between the thickness and moisture of SC in an animal sample of hairless mice. Our results indicate that body mass index and weight are associated with forearm SC moisture. This finding suggests that moisture of the ...
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A novel approach to modelling water transport and drug diffusion through the stratum corneum
... Recently, the potential for using skin as an alternative path for administering systemi- cally active drugs has attracted considerable interest [1]. Among some of the most active topics of research is the study of the ...
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An introduction to the transdermal delivery of antiretrovirals
... named stratum corneum (SC), stratum lucidum (clear layer), stratum granulosum (granular layer), stratum spinosum (prickly layer), and stratum ...the stratum ...
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Preferential arrangement of lipids in the long-periodicity phase of a stratum corneum matrix model
... Instead, the small amount of splitting length that is lost with the LPP-dNS/dFFA sample com- pared with a fully deuterated acyl chained sample (dFFA) can be attributed to two main fact[r] ...
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Characterization of stratum corneum molecular dynamics by natural-abundance 13C solid-state NMR
... and 60 u C than at 50 wt% water and 60 u C also supports the interpretation that hydration results in a monotonic increase of the fluid lipid fraction, the dynamics of which is gradually[r] ...
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In Vivo Electroporation of Skin and Biological Tissue: Theoretical model development and Numerical Investigation of Associated Thermo-Electrical and Structural Responses and Enhanced Mass Transport
... The thin (10 20 − μ m ) outermost layer of the skin, the stratum corneum (SC), acts as a barrier inhibiting transdermal drug delivery. The SC is composed of flat dead cell shells, called corneocytes, which ...
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Non-invasive Approaches for the Diagnosis of Autoimmune/Autoinflammatory Skin Diseases—A Focus on Psoriasis and Lupus erythematosus
... the stratum granulosum, the protein content of tapes decreases in parallel with the increase of tape number/depth of penetration (52, ...the stratum corneum (SC) via D-Squame tapes (54, ...
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