Stress Granules
mRNA cycles through hypoxia induced stress granules in live Drosophila embryonic muscles
... Under stress conditions, many housekeeping gene mRNAs are transla- tionally silenced, while translation of other mRNAs ...so-called stress granules containing both mRNAs and proteins. Stress ...
10
Stress Granules and P Bodies: An Insight into mRNA Translational Control and Decay
... into stress granules (Kato et ...into stress granules (Bentmann et ...to stress granules by forming aberrant associations with other proteins (Bentmann et ...both stress ...
13
Encephalomyocarditis Virus Disrupts Stress Granules, the Critical Platform for Triggering Antiviral Innate Immune Responses
... In response to stress, cells induce ribonucleoprotein aggregates, termed stress granules (SGs). SGs are transient loci containing translation-stalled mRNA, which is eventually degraded or recycled ...
12
Zika Virus Subverts Stress Granules To Promote and Restrict Viral Gene Expression
... cell stress response by preventing the formation of stress granules (SGs) and modulate viral gene expression by subverting different proteins involved in the stress granule ...of stress ...
22
MDA5 Localizes to Stress Granules, but This Localization Is Not Required for the Induction of Type I Interferon
... Virus infection can initiate a type I interferon (IFN-␣/) response via activation of the cytosolic RNA sensors retinoic acid-in- ducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). Furthermore, ...
12
Mammalian Orthoreovirus Particles Induce and Are Recruited into Stress Granules at Early Times Postinfection
... called stress granules (SGs), where they are held in a translationally inactive ...cellular stress response may play a role in the MRV replication ...
12
Rotavirus Infection Induces the Phosphorylation of eIF2α but Prevents the Formation of Stress Granules
... of stress granules, aggregates of stalled translation complexes that prevent the translation of ...these granules are not formed, suggesting that the virus prevents the assembly of these structures ...
9
Regulated protein aggregation: stress granules and neurodegeneration
... with stress granules ...other stress processes; these proteins couple SGs to the cytoskeleton and facilitate consolidation into a local region within the cell ...to stress, such as SGs, ...
12
Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis
... of stress granules and then with 4 % para- formaldehyde solution at room temperature for 15 - minutes followed by blocking and permeabilization with 5 % normal horse serum, ...
13
Antiviral Protein APOBEC3G Localizes to Ribonucleoprotein Complexes Found in P Bodies and Stress Granules
... The initial objective of this study was to identify potential cellular cofactors for A3G that may regulate, or contribute to, its cellular and antiviral functions. Proteins complexed with A3G were isolated using a ...
14
C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
... RNA stress granule proteins [16,17]. Stress granules (SGs) are cytoplasmic sites of stalled mRNA pre-initiation complexes induced by oxidative changes, heat shock or osmotic stress where the ...
22
Respiratory Syncytial Virus Induces Host RNA Stress Granules To Facilitate Viral Replication
... arsenite-induced stress granules as well ...induced stress granules, as well as RSV inclusion ...identify stress granules ...
11
Feline Calicivirus Infection Disrupts Assembly of Cytoplasmic Stress Granules and Induces G3BP1 Cleavage
... to stress such as virus infection, cells can stall translation by storing mRNAs away in cellular compartments called stress granules ...the stress is ...of stress pathway ...
13
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS
... ABSTRACT In response to virus-induced shutoff host protein synthesis, dynamic ag- gregates containing mRNA, RNA-binding proteins and translation factors termed stress granules (SGs) often accumulate within ...
15
Stable Formation of Compositionally Unique Stress Granules in Virus-Infected Cells
... for stress granule formation ...to stress granules ...oxidative stress-induced SGs, due to their dependence upon ongoing transcription, SG formation under both conditions utilizes pathways ...
12
Calcineurin Colocalizes with P-Bodies and Stress Granules during Thermal Stress in Cryptococcus neoformans
... of stress granules (SGs), where mRNAs are sequestered to prevent their trans- lation until the stress is alleviated ...the stress granule protein Pub1, a poly(A)-binding protein, was fused to ...
7
Hepatitis C Virus (HCV) Induces Formation of Stress Granules Whose Proteins Regulate HCV RNA Replication and Virus Assembly and Egress
... FIG 2 Stress granule induction in HCV-infected cells is dependent on PKR and is increased by IFN treatment. (A) Huh-7 cells were transduced with lentiviruses expressing shRNAs against PKR (shPKR) or a nontargeting ...
14
The chemotherapeutic agent bortezomib induces the formation of stress granules
... Stress granules (SGs) are cytoplasmic ribonucleopro- tein-containing bodies whose formation is favored by various stress conditions leading to eIF2α phosphoryla- ...these stress agents are ...
10
Stress Granules Regulate Double Stranded RNA Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1
... Caprin1 can interact with active PKR in cells (Fig. 3D, compare lanes 5 and 6). These results differ from in vitro pulldown experi- ments with purified proteins and likely reflect the presence of an additional ...
12
The RasGAP-associated endoribonuclease G3BP assembles stress granules
... proteins, stress-induced transcription factors, and formation of stress granules (SGs;* Theodorakis and Morimoto, 1987; Petersen and Lindquist, 1988; Nover et ...few granules per cell, and ...
9