striatal dopamine
Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects
... a striatal dopamine release [18], so this can transiently lead to increased dopamine ...increased dopamine levels, this would have resulted in a decrease of D2/3R availability and sub- ...
5
Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons
... dysfunction and degeneration through a toxic gain-of- function mechanism [14-16]. A number of transgenic mice have been created that express wild-type or mutant human α-synuclein in neurons from an array of different ...
14
Regulation of bat echolocation pulse acoustics by striatal dopamine
... of striatal dopamine could reveal the extent to which dopaminergic circuits contributed to the spontaneous production, modulation and variability of echolocation ...reduced dopamine levels caused by ...
10
Keep focussing: striatal dopamine multiple functions resolved in a single mechanism tested in a simulated humanoid robot
... Distinct functions are ascribed to striatal dopamine (DA) in rela- tion to the type of outflow (tonic/phasic) expressed by this neu- romodulator and the experimental context. “Tonic” DA release is caused by ...
17
Methamphetamine-induced changes in the striatal dopamine pathway in μ-opioid receptor knockout mice
... of dopamine receptors with agonists has been shown to cause down-regulation in expression of these receptors ...indirect dopamine receptor agonist, METH is known to stimulate the release and inhibit ...
10
Interactions between striatal dopamine and adenosine receptors: effects of aminophylline on a pharmacological model of parkinson's disease
... and dopamine receptor interaction in the striatum: In the CNS, there are several neurotransmitters responsible for acting as endogenous modulators, altering cellular functioning, providing the regulation of ...
11
A role for adenosine A1 receptor blockade in the ability of caffeine to promote MDMA "Ecstasy" induced striatal dopamine release
... 6 followed by the collection of four consecutive 4 min fractions of eluate to determine basal [³H]-DA outflow (Baseline). Over the following 32 min, slices were exposed to Krebs buffer containing different concentrations ...
36
Abnormal Striatal Dopamine Transmission in Schizophrenia
... [21] reported that abnormal presynaptic dopamine density (meas- ured by 6-[18F]-fluorodopa uptake) was lateralised to the left in patients with schizophrenia. Other studies have reported a dopa- minergic asymmetry ...
9
Caffeine and a selective adenosine A2A receptor antagonist induce sensitization and cross-sensitization behavior associated with increased striatal dopamine in mice
... therapeutic effects in animal models of PD, which are medi- ated by mesolimic and nigrostrial dopaminergic pathways projected to the striatum, it is reasonable to hypothesize that caffeine and selective A 2A antagonists ...
10
No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT
... decreased striatal DAT availability in smokers [28,33] using [ 99m Tc] TRODAT-1 ...the striatal presynaptic dopamine activity in active smokers (n = 9) compared to non-smokers (n = 10), a ...
7
Autism linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine dependent behaviors
... The dopamine (DA) system is a critical regulator of motor activ- ity, motivation, attention, and reward processing (1–4). Dopa- minergic projections originating from the substantia nigra and ventral tegmental area ...
14
Changes in Striatal N-methyl-D-aspartate (NMDA) Stimulation of Dopamine Release and Receptor Subunit Expression During Expression of and Recovery from MPTP-Induced Parkinsonism
... of striatal dopamine innervation in uni-lateral 6-OHDA lesioned rats alters glutamate receptor binding 26, 16, 28 and glutamate receptor subunit expression 4, 3 ...stimulates dopamine release (for ...
29
Striatal and extrastriatal dopamine transporter levels relate to cognition in Lewy body diseases: an 11C altropane positron emission tomography study
... of dopamine terminal density and dopamine concen- tration, or whether DAT levels and dopamine terminal density ...respect, striatal DAT levels in pri- mates correlate tightly with ...
10
Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s disease
... the striatal and extra-striatal ...of striatal dopamine release after am- phetamine challenge [33, 34], and this may have been more successful in differentiating the high-TH and low- TH ...of ...
14
Motivational valence is determined by striatal melanocortin 4 receptors
... with dopamine signaling would normalize the aversive response of the MC4R-KO ...Because striatal dopamine D1 receptors (D1R) are important for motivation and reward learning (18, 19), we injected a ...
12
Striatal Circuit Development and Its Alterations in Huntington’s Disease
... Several studies, in which deletion of wild-type Htt during development was performed, have enabled a better understanding of the multiple functions of the protein in the developing brain and especially in the striatum to ...
22
Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons
... and striatal tis- sue samples (three 5-10 fold dilutions), were coated in duplicates onto 96-well Immobilon plates overnight at 4°C in PBS ...total striatal protein, as determined by Bradford assay (BioRad ...
16
Striatal neuropeptides enhance selection and rejection of sequential actions
... indeed, striatal activity during motor chunking has been shown to correspond to the concatenation of sequence elements while cortical activity correlates with their segmentation (Wymbs et ...
17
Defining a role for the peduncolopontine tegmental nucleus in striatal outflow
... "Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the choli[r] ...
306
Interactions of the Striatal Gene Rhes with the Dopaminergic System in Rodents
... Dopamine (DA) is a catecholamine neurotransmitter and hormone formed by the decarboxylation of L-dopa (L-dihydroxyphenylalanine). In the brain, DA serves as a major neurotransmitter, mediating a diverse range of ...
66