STRUCTURAL BASIS
Structural Basis for the Receptor Binding Specificity of Norwalk Virus
... the structural basis for differences in ligand recognition of noroviruses from different genogroups, the prototypic Norwalk virus (NV; GI-1) and VA387 (GII-4), which recognize the same A antigen but differ ...
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Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus
... our structural studies on protease-inhibitor complexes, we have shown that the mechanism of inhibition involves covalent bond formation with the sulfhydryl of the conserved cysteine in the active site by nu- ...
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Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides
... Our results provide the structural basis for understanding the HMO binding to the human norovirus GII.10 P domain. We found that both 2=FL and 3FL were capable of blocking binding of GII.10 norovirus VLPs ...
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Structural basis for outer membrane lipopolysaccharide insertion
... detailed structural model should help us to better understand outer membrane LPS ...a structural basis for LPS translocation across the outer membrane and insertion into the outer ...
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Structural Basis for a Reciprocal Regulation between SCF and CSN
... Csn2, Csn3, and Csn4 are preceded by long N-terminal exten- sions, predicted to contain further helical repeats (Enchev et al., 2010; Pick et al., 2009). There is a striking similarity between the CSN subunit composition ...
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Structure determination of bovine B lactoglobulin variants A and B : the structural consequences of point mutations, the structural basis of the Tanford transition, the structural influence of ligand on bovine BLGA : [a thesis] submitted to Massey University as partial fulfilment of the requirements for the degree of Doctor of Philosophy in Chemistry
... The structural consequences of point mutations The structural basis of the Tanford transition The structural influence of ligand on bovine BLGA.. Submitted to Massey University as partia[r] ...
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Structural Basis of Bloom Syndrome (BS) Causing Mutations in the BLM Helicase Domain
... Background: Bloom syndrome (BS) is characterized by mutations within the BLM gene. The Bloom syn- drome protein (BLM) has similarity to the RecQ subfamily of DNA helicases, which contain seven conserved helicase domains ...
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Running performance has a structural basis
... Our idea that speed-specific ground support force requirements might explain the body mass variation present among highly adapted runners of different specializations was well supported by the elite human runners in our ...
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Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C Terminal Processing Proteases
... the structural basis for the activating role of the PDZ domain in regulating the activity of Prc, we have determined a set of crystal structures in the unliganded resting state of Prc, alone or in complex ...
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Structural Basis for Norovirus Inhibition and Fucose Mimicry by Citrate
... the structural basis by which citrate binds to the HBGA binding site of the norovirus ...the structural basis for norovirus interaction with ci- trate as revealed here may be helpful in such ...
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Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome
... the structural basis for drug resistance ...detailed structural information demon- strates that a common mechanism is at play in linezolid resistance and provides a step toward the redesign of ...
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Structural Basis for the Recognition of Lewis Antigens by Genogroup I Norovirus
... The majority of GI NoVs interact with the A antigen but not the B antigen (34), despite their structural resemblance; the A antigen has a terminal GalNAc, whereas the B antigen has a Gal at the same position. As ...
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Structural basis for DNA strand separation by a hexameric replicative helicase
... and structural studies support a similar mecha- nism in prokaryotic DnaB (18) and the dsRNA helicase Rho (8), among ...of structural data on complexes with DNA replication fork substrates could be explained ...
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Structural basis of human kinesin 8 function and inhibition
... antimitotic drugs. The clinical significance of these motors empha- sizes the importance of understanding the molecular basis of their function. Equally important, investigations into the modes of in- hibition of ...
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Structural basis for NKG2A/CD94 recognition of HLA-E.
... Our initial solvent-flattened map, which was unbiased with respect to NKG2A, showed structural features not easily predicted from sequence analysis alone. We attempted to use CD94 and NKG2D, the two closest ...
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Structural basis for potency differences between GDF8 and GDF11
... In this study, using a variety of in vitro and in vivo sys- tems, we show that GDF11 is significantly more potent than GDF8 and that the enhanced activity is due to dif- ferences in type I receptor utilization. In ...
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Structural Basis for the Recognition of Blood Group Trisaccharides by Norovirus
... Norwalk virus and VA387 belong to different genogroups, and they are the only two noroviruses with their P domain three-dimensional structures resolved. While they show overall structural similarity, the ...
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Structural Basis of DNMT1- and DNMT3A-Mediated DNA Methylation
... CXXC domain in inhibiting the de novo methylation activity of DNMT1, the major maintenance 192.. DNA methyltransferase.[r] ...
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Structural Basis for Human Norovirus Capsid Binding to Bile Acids
... ABSTRACT A recently developed human norovirus cell culture system revealed that the presence of bile enhanced or was an essential requirement for the growth of certain genotypes. Before this discovery, histo-blood group ...
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Structural basis for phospholyase activity of a Class III transaminase homolog
... activity is present in A1RDF1 however, leading to the conclusion that A1RDF1 probably has a different substrate and/or reaction specificity. We therefore compared the A1RDF1 sequence to those enzymes with experimentally ...
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