Structure of the HIV-1 protease
Structure Function Studies Of Hiv-1 Protease
... Multiple HIV-1 protease structures were used as input for docking experiments, including crystal structures of both wild type (PDB: 2S09) and MDR 769 (PDB: ...
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Whiskers-less HIV-protease: a possible way for HIV-1 deactivation
... the protease active site is covered by a pair of glycine rich, flexible, overlapping loops, extending from residue 43 to residue 58, called ‘flaps’ ...the protease active site include about 40 percent ...
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HIV-1 Protease-Substrate Coevolution in Nelfinavir Resistance
... complex structure was then evaluated by V in and V out (volumes of the substrate within and outside the substrate envelope, respectively), as described in detail elsewhere ...
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Data Mining Analysis of HIV-1 Protease Crystal Structures
... using HIV-1 protease crystal structures complexed with FDA approved HIV-1 protease inhibitor ...crystal structure, yielding approximately 600 constitutional, topological, ...
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Molecular Docking Studies; Dietary Compounds As HIV 1 Protease Inhibitors
... ACTION STRUCTURE Figure 5 HIV-1 protease activity is critical for the terminal maturation of infectious ...Once HIV enters the cell, viral RNA undergoes reverse transcription to produce ...
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Optimizing HIV-1 protease production in Escherichia coli as fusion protein
... this protease, it is difficult to obtain it in large quantities: in most cases the expression level was low and the recombinant HIV-1Pr could be detected only by immunoblotting (see Additional file ...
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QSAR Study and Determination of More Potent Peptidic HIV-1- Protease Inhibitors
... peptidic HIV-protease inhibitors has been ...the structure activity relationship discussion it is clear that log P is an important parameter for QSAR ...
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Designing fluorescent peptide sensors with dual specificity for the detection of HIV‑1 protease
... Simulated structure of HIV-1 PR complexed with peptide nanosensors: (a) The most populated cluster from REST simulations showing both peptide−dye conjugates bound to the protease flaps on ...
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Effects of HIV-1 protease on cellular functions and their potential applications in antiretroviral therapy
... Yang 1 , Joseph Nkeze 2 and Richard Y Zhao 2,3,4* Abstract Human Immunodeficiency Virus Type 1 (HIV-1) protease inhibitors (PIs) are the most potent class of drugs in antiretroviral ...
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The comparative analysis of the protease molecule structure of the Human lymphotropic virus type-1 (HTLV-1)
... spatial structure of the protein tertiary structure is viewed in the second ...and HIV-1 protease structure and sequence, the enzymatic digestion and substrate binding sites were ...
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A new approach for HIV 1 protease cleavage site prediction combined with feature selection
... 4. CONCLUSION Feature selection is a new approach for HIV-1 protease cleavage site prediction. Different from traditional meth- ods, our work eliminates the redundant features, simpli- fies the ...
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Protease mediated maturation of HIV: Inhibitors of protease and the maturation process
... rational structure-based drug design unfeasible at the current ...in HIV-1 particle ...inhibit HIV-1 replication can target Gag cleavage ...of HIV-1 replication ...
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Crystal structure of an FIV/HIV chimeric protease complexed with the broad based inhibitor, TL 3
... in HIV PR, while retaining hydrogen bonding interactions common to both FIV and HIV ...of HIV-1 and FIV protease (PR) substrate specificities in vivo, and are rele- vant to the ...
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Constraints on HIV-1 Diversity from Protein Structure
... This structure must be protease resistant, must not aggre- gate, and in some cases must be inserted into the membrane. The required binding sites and active sites must form effi- ciently in three dimensions ...
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Human Immunodeficiency Virus (HIV) Type 1 Transframe Protein Can Restore Activity to a Dimerization-Deficient HIV Protease Variant
... the structure-function relation- ships of PR by combining two bacterial genetic tools, an Esch- erichia coli genetic assay for proteolytic activity and a bacterial two-hybrid (BACTH) system, both based on ...
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HIV 1 protease induced apoptosis
... active HIV-1 PR induces death in HeLa and HEK-293 cells via the mitochondrial apoptotic ...of HIV-1 PR in mitochondria, a key player in triggering ...an HIV-1 PR ...
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Design and synthesis of inhibitors for the HIV 1 protease
... would prevent them from crossing cell membranes, as the lipid bilayers are highly impermeable to ionised molecules. The problem of ionisation is not inherent in the phosphonamidate methyl ester analogues and consequently ...
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HIV-1 Protease, Reverse Transcriptase, and Integrase Variation
... ABSTRACT HIV-1 protease (PR), reverse transcriptase (RT), and integrase (IN) variability presents a challenge to laboratories performing genotypic resistance ...low-abundance HIV-1 ...
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Cleavage of eIF4G by HIV-1 protease: effects on translation
... of HIV-1 PR-mediated cleavage of eIF4GI on translation in HeLa cell ...ng HIV-1 PR (with or without ...of HIV-1 PR and an aliquot was taken to analyze the integrity of eIF4G ...
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SensoLyte 520 HIV-1 Protease Assay Kit *Fluorimetric*
... aspartic protease of human immunodeficiency virus-1 (HIV-1) is required for the post-translational cleavage of the precursor polyproteins, Pr gag and Pr gag-pol .... 1 These cleavages ...
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