Structure of tetrameric human mannose binding lectin (74)
The pandemic (H1N1) 2009 influenza virus is resistant to mannose binding lectin
... pathogenesis. Human seasonal influenza A viruses are susceptible to mannan-binding protein, also known as mannose-binding lectin (MBL) [4-9], which is an acute protein produced by the ...
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Complement Mediated Neutralization of Dengue Virus Requires Mannose Binding Lectin
... ABSTRACT Mannose-binding lectin (MBL) is a key soluble pathogen recognition protein of the innate immune system that binds specific mannose-containing glycans on the surfaces of microbial ...
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Original Article Serum mannose-binding lectin levels in patients with ischemic stroke
... One hundred and seventy-five age- and sex- matched subjects (control group) were included as controls. The healthy subjects were enrolled from the Health Physical Examination Center of our hospital. They had no known ...
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Mannose binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis
... Alternative hypotheses have been proposed to explain the pregnancy-induced improvement of RA, such as the induction of regulatory T cells, immunomodulatory properties of pregnancy hormones, a shift towards a ...
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Association of mannose binding lectin gene polymorphisms with the development of pulmonary tuberculosis in China
... Methods: A total of 112 inpatients with pulmonary TB and 120 healthy controls were recruited to participate in this case – control study. Polymerase Chain Reaction-Restriction Fragment Length Polymorphism(PCR-RFLP) ...
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Mannose Binding Lectin as a Diagnostic Marker for Coronary Artery Disease in Hypertensive Patients
... 4. The C- terminal carbohydrate recognition domain ( CRD ) is responsible for pattern recognition and consists of 118 aminoacids (65,67–69) MBL recognizes sugar patterns on the surface of many pathogens, phospholipids, ...
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Mannose-Binding Lectin Deficiency Facilitates Abdominal Candida Infections in Patients with Secondary Peritonitis
... of mannose-binding lectin in the innate defense against Candida albicans: enhancement of complement activation, but lack of opsonic function, in phagocytosis by human dendritic ...
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Dietary sugars inhibit biologic functions of the pattern recognition molecule, mannose binding lectin
... In this study, we investigated the effects of dietary sugars and its effect on innate immunity against common human pathogens, IAV and S. aureus. We observed that fructose negatively regulate MBL-mediated innate ...
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Mannose Binding Lectin Genotypes Influence Recovery from Hepatitis B Virus Infection
... To investigate the hypothesis that mbl2 SNPs may be associated with recovery from acute hepatitis B, a nested case control design was used. When possible, participants from the cohorts with persistent HBV infections were ...
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Elevated levels of vitamin D and deficiency of mannose binding lectin in dengue hemorrhagic fever
... dengue specific IgM ELISA and leftover aliquots were stored in -80°C. A total number of 93 samples, which were positive for dengue specific IgM ELISA, were included in the study. All the samples were collected during the ...
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Mannose binding lectin deficiency with eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in children: a case series
... Serum levels of immunoglobulin A (IgA), IgM and IgG were quantified by an immunodiffusion technique using NOR Partigen immunoplates purchased from Siemens (Marburg, Germany). The levels of IgE in serum were quantified by ...
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Increased plasma mannose binding lectin levels are associated with bronchiolitis obliterans after lung transplantation
... al: Mannose-binding lectin engagement with late apoptotic and necrotic ...of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with ...
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Pilot study: deficiency of mannose binding lectin dependent lectin pathway, a novel modulator in outcome from pancreatic islet auto transplantation
... Unpurified whole pancreatic digest was suspended in M199 transplant media containing 20% human serum albumin. Islets were prepared while the surgeons completed the enteroenterostomy and choledochojejunostomy ...
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Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice
... protective IgM response has been linked to Th2 induction thus providing a bridge between glycan induction of both Th2 and IgM responses 27. A key aspect of eliciting optimal immunity, which is frequently overlooked in ...
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Mannose binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study
... 7. Saifuddin M, Hart ML, Gewurz H, Zhang Y, Spear GT: Interaction of mannose-binding lectin with primary isolates of human immunodeficiency virus type 1. J Gen Virol 2000, 81:949-955. 8. ...
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Human mannose binding protein functions as an opsonin for influenza A viruses
... serum lectin mannose- binding protein directly inhibits hemagglutinin activity and infectivity of several strains of ...addition mannose-binding protein acts as an opsonin, enhancing ...
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Association study of mannose-binding lectin levels and genetic variants in lectin pathway proteins with susceptibility to age-related macular degeneration: a case-control study
... the lectin pathway, and MBL and ficolin-2 in particular, might indeed not be involved in the pathogenesis of ...the lectin pathway in AMD, might not have been able to account for the complexity of ...
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Association between Mannose-Binding Lectin Deficiency and Septic Shock following Acute Pyelonephritis Due to Escherichia coli
... The human experimentation guidelines of the ...and Human Services and those of the authors’ institutions were followed in conduct- ing the clinical ...
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Serum Mannose-Binding Lectin Concentration, but Not Genotype, Is Associated With Clostridium difficile Infection Recurrence: A Prospective Cohort Study
... 23. Butt E, Foster JA, Keedwell E, et al. Derivation and validation of a simple, accurate and robust prediction rule for risk of mortality in patients with Clostridium difficile infection. BMC Infect Dis 2013; 13:316. 24. ...
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Significance of mannose-binding lectin deficiency and nucleotide-binding oligomerization domain 2 polymorphisms in Staphylococcus aureus bloodstream infections: a case-control study
... like mannose-binding lectin (MBL) and nucleotide-binding oligomerization domain 2 (NOD2) are among the first immune responses to Staphylococcus aureus ...but human data are ...
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