Suberoylanilide Hydroxamic Acid
Effects of suberoylanilide hydroxamic acid (SAHA) combined with paclitaxel (PTX) on paclitaxel-resistant ovarian cancer cells and insights into the underlying mechanisms
... [9-11]. Suberoylanilide hydroxamic acid (SAHA) is a HDACI that shows strong anti-proliferative effects on various cancer cell lines and is currently in clinical trials for the treatment of certain ...
11
The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) and MG132 on the aggressive phenotypes of gastric cancer cells
... The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid SAHA and MG132 on the aggressive phenotypes of gastric cancer cells Hang Lu1, Xue-fen[r] ...
18
Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti tumor effects of the poly (ADP ribose) polymerase (PARP) inhibitor olaparib in triple negative breast cancer cells
... whether suberoylanilide hydroxamic acid (SAHA), a HDAC inhibitor, could enhance the anti-tumor effects of olaparib on breast cancer cell lines using a cytotoxic assay, cell cycle analysis, and ...
13
Original Article Suberoylanilide hydroxamic acid inhibits proliferation and promotes apoptosis of mouse myeloma Sp2/0 cells through activating p53/caspase-3 signaling
... Abstract: Multiple myeloma (MM) is considered as one of the largest contributors to cancer-related deaths in the world. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, is ...
9
Suberoylanilide hydroxamic acid (SAHA) reverses chemoresistance in head and neck cancer cells by targeting cancer stem cells via the downregulation of nanog
... The characteristic of cell lines [51, 52] (origin, p53 status, HPV status) are presented in Supplementary Table S2. Normal human oral keratinocytes (HOK) were purchased from ScienCell (Carlsbad, CA). Cisplatin (CDDP) was ...
13
Epigenetic therapy potential of suberoylanilide hydroxamic acid on invasive human non-small cell lung cancer cells
... of suberoylanilide hydroxamic acid (SAHA) on invasive cancer cells, and found that SAHA suppresses cancer cell invasiveness and sensitizes cancer cells to treatments of IR and chemotherapeutic ...
13
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
... Huntington’s disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG 兾 polyglutamine repeat expansion and for which there is no effective therapy. Recent evidence indicates that ...
7
The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-γ
... SAHA: Suberoylanilide hydroxamic acid; SOCS: Suppressors of cytokine signaling; STAT: Signal transducer and activator of transcription; TNF: Tumor necrosis factor; TSA: Trichostatin ...
8
Suberoylanilide hydroxamic acid induces apoptosis and sub-G1 arrest of 320 HSR colon cancer cells
... HDACi, suberoylanilide hydroxamic acid (SAHA), has promising anticancer activity through covalent modification of histone pro- teins, specifically inhibiting ...
9
Original Article Effects of suberoylanilide hydroxamic acid on rat cytochrome P450 enzyme activities
... inhibitors, suberoylanilide hydroxamic acid (also known as SAHA or Vorinostat) has emerged as the first HDACi approved by the FDA in 2006 for the ...
7
Suberoylanilide Hydroxamic Acid as a Potential Therapeutic Agent for Human Breast Cancer Treatment
... Fig. 2. Human breast cancer cells are more sensitive to SAHA-mediated cell killing than normal cells. (A) Trypan blue exclusion assays of MCF7, MCF-10A, and fibroblast cells that had been treated for 48 hr with ...
18
Suberoylanilide hydroxamic acid represses glioma stem-like cells
... Background: Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM ...
12
Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth
... (suberoylanilide hydroxamic acid [SAHA]), structurally related to but 2000-fold more potent than HMBA, was an inhibitor of histone deacetylase activity and caused accumulation of hyperacetylated ...
12
Molecular mechanism leading to SAHA-induced autophagy in tumor cells: evidence for a p53-dependent pathway
... Suberoylanilide hydroxamic acid (SAHA), an inhibi- tor of class I and II HDACs, was previously admitted for therapeutic treatment of cutaneous T cell lymphoma ...
15
Chemical hypoxia in human pluripotent NT2 stem cell-derived neurons: Effect of hydroxamic acid and benzamide-based epigenetic drugs
... Pharmacological inhibition of these epigenetic modifiers, histone deacetylases (HDACs) is vital for protection against many pathological disorders. Alteration in these epigenetic factors may be a beneficial approach to ...
8
The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling
... valproic acid sodium salt (VPA), Tween 80, suberoylanilide hydroxamic acid (SAHA), tubacin, 3-methyladenine (3-MA), propidium iodide (PI), dimethyl sulfoxide (DMSO), Hoechst 33342, and MG132 ...
15
PLGA PEG Nanoparticles Coated with Anti CD45RO and Loaded with HDAC Plus Protease Inhibitors Activate Latent HIV and Inhibit Viral Spread
... poly(lactic-co-glycolic acid)- polyethylene glycol diblock copolymers conjugated with anti-CD45RO antibody and loaded with the histone deacetylase inhibitor suberoylanilide hydroxamic acid ...
8
Suberoyl bis-hydroxamic acid enhances cytotoxicity induced by proteasome inhibitors in breast cancer cells
... bis-hydroxamic acid (SBHA) has a similar structure to suberoylanilide hydro- xamic acid (SAHA) and trichostatin A (TSA), two of the mostly studied HDAC ...
7
Two pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid based inhibitors
... of hydroxamic acid-based inhibitors suggest that the sca ff old is capable of reaching the site of action within cultured erythrocytes, 10 making this a promising sca ff old for further ...
16
The hydrolysis of hydroxamic acid complexants in the presence of non oxidizing metal ions 1: Ferric ions
... propanhydroxamic acid in sulphuric and nitric acid and found that both acids exert an identical catalytic effect with the rates passing through a maximum as a function of [H + ] ...
32