Subgroup analysis methods for IPD from trials
How should individual participant data (IPD) from publicly funded clinical trials be shared?
... Clinical Trials Units (CTU) Network was undertaken to ascertain current data sharing activities, good practices and pos- sible barriers to sharing IPD from the perspective of or- ganisations ...
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Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use
... of IPD in systematic reviews, as a consequence of the drive for greater sharing of data held within trials, guidance on appropriate methodology will become ever more ...standard IPD meta-analyses, ...
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Individual participant data (IPD)-level meta-analysis of randomised controlled trials among dark-skinned populations to estimate the dietary requirement for vitamin D
... crucial from a public health perspective in providing a framework for the prevention of vitamin D ...(IPD) from selected randomised controlled trials (RCTs) of white children and adults ...
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Individual participant data (IPD)-level meta-analysis of randomised controlled trials among dark-skinned populations to estimate the dietary requirement for vitamin D
... and IPD integrity For each eligible RCT, the collaboration will be re- quested and negotiated with the principal investigator ...The IPD request will include the following variables, where available: ...
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A comparison of the statistical performance of different meta-analysis models for the synthesis of subgroup effects from randomized clinical trials
... across trials, we may notice a considerable between-trial ...use methods that incorporate this additional variability in the estimation of confidence intervals around the pooled effect ...conduct ...
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Subgroup identification in clinical trials: an overview of available methods and their implementations with R
... further analysis, thus the data frame is first transformed before fitting a base ...each subgroup, the model is computed and again tested for parameter ...
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Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trials
... review methods including explicit and reproducible eligibility criteria, sensitive search strategies, and the use of standardized, pilot-tested forms accompa- nied by written instructions for study screening and ...
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Heterogeneity of patients in clinical trials: Subgroup analysis and covariate adjustment in cardiovascular and neurosurgical trials
... other trials according to their inclusion ...respectively. Trials with more homogeneous patients may have a more limited benefit from covariate ...used trials conducted between 1984 and 1997, ...
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Methods for the Analysis of Pretest-Posttest Binary Outcomes from Cluster Randomization Trials
... intracluster correlation. The cluster-specific extensions of PO and ANCOVA are valid across all parameter combinations. The empirical power for these two methods was comparable in many scenarios. However, ...
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Treating Individuals 2 Subgroup analysis in randomised controlled trials: importance, indications, and interpretation
... explanatory trials with well-defined eligibility criteria should be easy to apply, but general- isability is often undermined by highly selective recruitment, resulting in trial populations that are unrep- ...
A Critical Review of Graphics for Subgroup Analyses in Clinical Trials
... for subgroup analysis starts with the full population that branches into two or more items, corresponding to the levels of the first subgroup-defining ...the subgroup sample ...independently ...
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Bayesian methods in clinical trials: a Bayesian analysis of ECOG trials E1684 and E1690
... clinical trials, E1684 and ...accrued from 1984 to 1990, and the study was unblinded in 1993 and published in 1996 ...time from randomization until progression of tumor or death, whichever comes ...
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Aspirin for Primary Prevention of Cardiovascular Events: Meta-Analysis of Randomized Controlled Trials and Subgroup Analysis by Sex and Diabetes Status
... several methods to mitigate these adverse effects, for example, clinicians can remind those patients who decide to begin or continue an aspirin regiment for primary prevention of CVD, of the early recognition of ...
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Individual Emotion Recognition and Subgroup Analysis from Psychophysiological Signals
... evaluation methods, the normal split and random split methods are applied using both x= ...evaluation methods adopted here are based on a pre-selection from two previous studies ...explicit ...
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Does Sex Modify the Effect of Endovascular Treatment for Ischemic Stroke? A Subgroup Analysis of 7 Randomized Trials
... importance. This is best done by combining prognostic infor- mation from multiple clinical and radiological characteristics. 9 However, uncertainty remains about the size of the treatment effect in specific ...
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Subgroup analysis of large trials can guide further research: a case study of vitamin E and pneumonia
... of subgroup analysis is an exaggerated r ...subgroups from being for- gotten or destroyed by excessive vehemence in suggestions that all subgroups are ...of subgroup analysis because of ...
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Sex based subgroup differences in randomized controlled trials: Empirical evidence from Cochrane meta-analyses
... sex subgroup analyses without considering biological or clinical ...sex subgroup analyses in trials with- out generating a greater burden of false positive signals in subgroup ...Sex/Gender ...
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A comparison of methods to adjust for continuous covariates in the analysis of randomised trials
... Either FP1 or FP2 models could be used in practice. It is possible to use the trial data to select between FP1 and FP2 models, however we do not recommend this approach, as covariate selection procedures have been shown ...
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Recombinant activated factor VII as an adjunctive therapy for bleeding control in severe trauma patients with coagulopathy: subgroup analysis from two randomized trials
... Our analysis of data from coagulopathic patients treated with adjunctive rFVIIa revealed a significant improvement in clinical outcome as compared with ...
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Targeted Therapies: Adaptive Sequential Designs For Subgroup Selection In Clinical Trials
... final analysis on statistics that are not sufficient, and are hence ...such trials has been discussed at great length; see for example Tsiatis and Mehta (2003), Jennison and Turnbull (2003, 2006b) and ...
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