superparamagnetic iron oxide nanoparticles (SPIOs)
Ultrasmall cationic superparamagnetic iron oxide nanoparticles as nontoxic and efficient MRI contrast agent and magnetic-targeting tool
... The nanoparticles are cleared from kidneys and bladder in few days, whereas the complete elimination from liver and spleen occurred only after 4 ...ultrasmall superparamagnetic iron oxide ...
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Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
... Notes: Mesenchymal cells were harvested from bone marrow of wistar rats and cultured for three passages. They were then incubated with Feridex (50 μg/mL) and protamine (5.0 μg/mL) for 4 hours and trypsinized for ...
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Metabolic pathway and distribution of superparamagnetic iron oxide nanoparticles: in vivo study
... of superparamagnetic iron oxide ...Neither iron storage in hepatocytes nor fibrosis is ...minute iron deposits in a Kupffer cell flanking a ...(A) Iron granules are readily ...
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RADIATION DOSE ENHANCEMENT EFFECTS OF SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES TO THE T24 BLADDER CANCER CELL LINES IRRADIATED WITH MEGAVOLTAGE PHOTON BEAM RADIOTHERAPY
... metallic nanoparticles such as gold nanoparticles have been extensively investigated and intriguing finding have been ...reported. Superparamagnetic iron oxide nanoparticles ...
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Citrate capped superparamagnetic iron oxide nanoparticles used for hyperthermia therapy
... Here we successfully capped citrate on the surface of superparamagnetic iron oxide nanoparticles as a hyper- thermia device. The use of hyperthermia in the treatment of malignant tumors is as ...
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Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles
... Phagocytized SPIOs were mainly located proximal to the nucleus, indicating an irreversible trafficking to the endolysosomal ...compartment. SPIOs were taken up by an active temperature-dependent ...cellular ...
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Ultrasmall superparamagnetic iron oxide nanoparticles acutely promote thrombosis and cardiac oxidative stress and DNA damage in mice
... (0.25 μg/mouse of 25 g) would correspond to approxi- mately 0.16 μg/ml, assuming a circulating mouse blood volume of 1.5 ml. One of the reasons why we wanted to use lower dose of USPIO in our study is because we wanted ...
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Magnetic resonance sentinel lymph node imaging and magnetometer-guided intraoperative detection in prostate cancer using superparamagnetic iron oxide nanoparticles
... A total of 50 consecutive patients with intermediate- or high-risk PCa (prostate-specific antigen [PSA] 10 ng/mL and/or Gleason score 7) scheduled to undergo transrectal SPION injection before magnetometer-guided sLND ...
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Drug delivery to atherosclerotic plaques using superparamagnetic iron oxide nanoparticles
... of iron load per cell confirmed SPION uptake (Figure 3C). The iron concentrations in PBMCs treated with SPION and SPION-DEXA for 48 hours were ...cellular iron concentration within 72 hours ...
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Particokinetics: computational analysis of the superparamagnetic iron oxide nanoparticles deposition process
... for nanoparticles deposited in a suspension or liquid medium, involve parabolic-type partial ...the nanoparticles located adjacent to the cells, ie, experimental design, analytical and computational ...
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Quantification of the internalization patterns of superparamagnetic iron oxide nanoparticles with opposite charge
... [6,7,27,28], superparamagnetic iron oxide NPs (SPIONs) were selected as systems to investigate NP internalization patterns; firstly qualitatively via flow cyto- metry (Fluorescence-Activated Cell ...
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Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers
... a core ranging between 10 nm and 100 nm in diameter. These magnetic particles are coated with certain biocompatible polymers, such as dextran or polyethylene glycol, which provide chemical handles for the conjugation of ...
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Targeting experimental orthotopic glioblastoma with chitosan-based superparamagnetic iron oxide nanoparticles (CS-DX-SPIONs)
... The composite shell (between chitosan and dextran) cross- linked by TPP does not hamper the diffusion of protons into dephasing volume around MNPs thus preserving the MRI contrast-enhancing properties of the particles. ...
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One-Pot Facile Synthesis of New 1, 2, 4-Triazolidine Derivatives Using Sodium Borohydride and Fe3O4 Magnetic Nanoparticles (MNPs)
... Recently, superparamagnetic iron oxide nanoparticles (SPIONs) have been intensively investigated because of their super paramagnetic properties, excellent catalytic activity in organic ...
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In vitro Study of SPIONs-C595 as Molecular Imaging Probe for Specific Breast Cancer (MCF-7) Cells Detection
... agents to specifically target cancer cells has previously been demonstrated for several cancers [2,6-10] . Shahbazi- Gahrouei et al. [6,7] investigated the detection of ovarian cancer (OVCAR3) cells using C595 monoclonal ...
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Bio-functionalized dense-silica nanoparticles for MR/NIRF imaging of CD146 in gastric cancer
... Methods: Superparamagnetic iron oxide nanoparticles (SPION) were coated with dSiO 2 as core–shell nanoparticles, and labeled with near infra-red fluorescence (NIRF) dye 800ZW ...
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Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo
... hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intrave- nous administration in tumour-bearing ...of ...
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MRI of Breast Tumor Initiating Cells Using the Extra Domain-B of Fibronectin Targeting Nanoparticles
... targeting superparamagnetic iron oxide nanoparticles (SPIONs) could be used as a magnetic resonance imaging (MRI) contrast agent for BTIC imaging in vitro and in ...
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Remote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?
... Abstract: Magnetic resonance imaging (MRI) allows for an accurate assessment of both functional and structural cardiac parameters, and thereby appropriate diagnosis and validation of cardiovascu- lar diseases. The ...
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Selection of potential iron oxide nanoparticles for breast cancer treatment based on in vitro cytotoxicity and cellular uptake
... Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) are promising tools for the treatment of different diseases. Their magnetic properties enable therapies involving magnetic drug ...
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