Surfactant Protein
Population-Based Estimates of Surfactant Protein B Deficiency
... of surfactant protein B deficiency, 89 infants had clinical information in chart reviews or autopsy re- ports that was not consistent with the known surfac- tant protein B clinical phenotype (Table ...
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Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study
... C-reactive protein, CRP) correlate with disease severity and with adverse health outcomes of patients with mild to moderate disease ...desirable. Surfactant protein D (SPD) and Clara cell pro- ...
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Interactions of surfactant protein D with bacterial lipopolysaccharides Surfactant protein D is an Escherichia coli binding protein in bronchoalveolar lavage
... collagenous C-type lectins, including serum conglutinin, serum mannose-binding proteins, and surfactant protein A. Preliminary studies showed calcium- and saccharide-dependent binding of ...
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MOLECULAR DOCKING AND MUTATIONAL STUDIES OF HUMAN SURFACTANT PROTEIN –D
... space surfactant proteins plays active role in the defense mechanism among all the surfactant proteins, Surfactant protein-D (SP-D) plays a crucial role in the host defense and in allergic ...
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Development of a Synthetic Surfactant Using a Surfactant Protein C Peptide Analog: In Vitro Studies of Surface Physical Properties
... Most of the commercially used artificial PSs are derived from animal (cow or pig) lung tissue. These animal-derived PSs con- tain surfactant protein (SP) from animal lung extracts, a point that raises ...
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Cholesterol-Mediated Dysfunction of Surfactant Effects of Surfactant Protein-A and Diet-Induced Hypercholesterolemia
... pulmonary surfactant system. As noted above, surfactant is a lipoprotein complex found within alveoli and its main purpose is to reduce surface tensions within the ...lungs. Surfactant is ...
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The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D
... [4], surfactant protein (SP)-A and SP-D [5,6], matrix metalloproteinase (MMP)1 and MMP7 [7], brain natriuretic peptide [8], and, most recently CC- chemokine ligand 18 [9] are elevated in patients with ...
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The Porcine Pulmonary Surfactant Protein A (pSP A) Immunogenicity Evaluation in the Murine Model
... produce surfactant protein A, SP-A. This protein belongs to a group of soluble humoral pat- tern recognition receptors, called collectins, which mod- ulate the immune response to microorganisms ...
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Surfactant protein-D and pulmonary host defense
... Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the ...specific ...
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Engineering novel complement activity into a pulmonary surfactant protein
... separate protein families, C1q, mannose-binding lectins (MBLs) and serum ...pulmonary-surfactant protein (SP-A), which has the same domain structure and architecture as MBL, but lacks any intrinsic ...
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Generation of lyso phospholipids from surfactant in acute lung injury is mediated by type II phospholipase A2 and inhibited by a direct surfactant protein A phospholipase A2 protein interaction
... that surfactant is a major lung target of ...hydrolyze surfactant phospholipids in ...by surfactant protein A (SP-A) through a direct and selective protein–protein inter- action ...
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A Combination of Short and Simple Surfactant Protein B and C Analogues as a New Synthetic Surfactant: In Vitro and Animal Experiments
... pulmonary surfactant consists of 86% phospholipids, 8% neutral lipids, and 6% ...artificial surfactant replacement therapy was introduced clini- cally, mortality in premature infants has remarkably improved ...
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Failure to Detect Surfactant Protein-Specific Antibodies in Sera of Premature Infants Treated With Survanta, A Modified Bovine Surfactant
... The present study was con- ducted to assess whether antibodies generated against bovine surfactant proteins SP-B or SP-C could be detected in serum from infants treated with Survanta for[r] ...
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Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium
... 5% skimmed milk for non-phosphorylated proteins and 5% BSA for phosphorylated proteins. The membrane was then incubated overnight at 4°C in respective primary anti- bodies in TBST containing 2.5% skimmed milk for non- ...
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Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
... However, protein levels were not statistically different between groups making it rather unlikely that differences in BAL dilution are responsible for the observed differences in BAL SP-D concentra- ...
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EMC3 coordinates surfactant protein and lipid homeostasis required for respiration
... EMC3 interacts with ABCA3 and controls ABCA3 stability. Since EMC3 was previously shown to influence folding of multi- pass transmembrane proteins, including AChRs and rhodopsin (10–13), we sought to test whether EMC ...
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Surfactant protein A enhances respiratory syncytial virus clearance in vivo
... Administration of exogenous SP-A may increase the free SP-A available to enhance viral clearance. Treatment of wild-type mice with SP-A did not enhance clearance or decrease inflammation in the lung, suggesting that ...
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120 kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein A
... internalized or degraded by the P. carinii organism. Furthermore, SP-A binding to P. carinii is time- and calcium-dependent and is competitively inhibited by mannosyl albumin. In the absence of calcium or the presence of ...
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Clinical and genetic spectrum of interstitial lung disease in Chinese children associated with surfactant protein C mutations
... genetic surfactant dysfunction and then referred for candidate gene sequencing in the laboratory at Children’s Hospital of Fudan University between 2013 and ...
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On the significance of Surfactant Protein-A within the human lungs
... Since SP-A represents a central molecule in pulmonary immunoregulation as well as in host-defense it is obvious that defects in the surfactant system may have functional influence in the course of these pulmonary ...
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