Survivin gene
Original Article Association between survivin gene -31G/C and 9194A/G polymorphisms and lung cancer susceptibility: meta-analysis of six studies
... Abstract: Survivin expression may be associated with elevated cancer ...in survivin appear to be associated with lung cancer susceptibility, although the results remain ...between survivin ...
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Down Regulation of Survivin Gene and Up Regulation of p53 Gene expression by siRNA Induces Apoptosis in human Hepatocellular Carcinoma cell Line HepG2
... Total RNA was extracted from HepG2 cell using Trizol reagent (Gibco BRL) according to the manufacturer’s instructions. Complementary DNA (cDNA) was gener- ated from total RNA using M-MLV. PCR of cDNA was performed in a ...
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Original Article EP300 regulates the expression of human survivin gene in esophageal squamous cell carcinoma
... EP300 gene is often found mutated in various human cancers [11, ...in survivin transcriptional regulation has not been ...that survivin expression is repressed by EP300 in esopha- geal cancer ...
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Original Article Ultrasound-targeted microbubble destruction promotes lipofectamine-mediated shRNA-survivin transfection efficiency thereby inhibiting survivin expression and inducing apoptosis of HepG2 cells
... [22]. Survivin is a mem- ber of the mammalian inhibitor of apoptosis protein family, which has become the best studied anti-apoptotic protein ...[13]. Survivin is overexpressed in the majority of tumors, ...
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Original Article Coexpression of survivin and livin predicts lymph node metastasis and poor prognosis in cervical cancer
... between survivin and livin expression and clinical features, and the prognosis of patients with cervical ...The survivin gene locates on chromosome 17q25 with the length of ...[17]. Survivin ...
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Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation
... tissues. Survivin knockout mice die at an early stage of development due to defects in mitosis ...of Survivin neuronal precursor cells from ...shown Survivin gene expression in the postnatal ...
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Cancer gene therapy using a survivin mutant adenovirus
... (IAP) gene family control a downstream step in cell death by suppressing processing and catalytic activity of caspases, the executioners of cell death programs ...the survivin gene (7). ...
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Gene Expression of Survivin in Colorectal Cancer
... The survivin gene locus encodes multiple genetic splice variants with unique properties and functions ...[6][7]. Survivin accumulates in the centromeres in G2 phase, and then it starts to diffuse to ...
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The oncofetal gene survivin is re expressed in osteoarthritis and is required for chondrocyte proliferation in vitro
... tumor gene survivin has been extensively studied in cell cycle and apoptosis assays in tumor cells, with lit- tle available data in primary cells and chondrocyte biol- ogy so far ...of survivin ...
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Original Article IKKα/IKKβ/NFκB/SURVIVIN expression regulated by E2F1 in esophageal cancer cell line ECA109
... the SURVIVIN gene is vital in promoting cell mitosis and proliferation, and inhibiting cell ...and SURVIVIN are cis-ex- ...Although SURVIVIN is currently the strongest apoptosis inhibitor, its ...
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Targeted Hsp70 expression combined with CIK-activated immune reconstruction synergistically exerts antitumor efficacy in patient-derived hepatocellular carcinoma xenograft mouse models
... HCC, gene therapy and cell therapy have become important adjuvant ...targeting gene therapy were ...specific Survivin gene promoter to mediate the targeting expression of Hsp70 or P53 ...
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Original Article Targeting survivin suppresses proliferation and invasion of retinoblastoma cells in vitro and in vivo
... For standard immunohistochemistry analysis, retinoblastoma tissue samples were fixed in 4% formalin and dehydrated. Then, the tissues were embedded in paraffin. Immunohistoche- mistry assays were performed on 4-μm thick ...
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Survivin gene levels in the peripheral blood of patients with gastric cancer independently predict survival
... TaqMan Gene Expression Assays specific for CEA, CK19, Survivin and VEGF were purchased from Applied ...TaqMan Gene Expression assay (all reagents from Applied Biosystems), ...
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Nuclear survivin: cellular consequences and therapeutic implications
... of survivin is the loss of its cytoprotective ...nuclear survivin naturally occurs (Temme et ...nuclear survivin can no longer inhibit cell death, invoked by either the intrinsic or extrinsic ...
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Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis
... of survivin in cancer, as opposed to normal tissues ...tumors, survivin is expressed at all cell cycle phases, thus making unlikely a sole role at mito- sis, and it correlates with clinical phenotypes ...
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Survivin co-ordinates formation of follicular T-cells acting in synergy with Bcl-6
... Chromatin immunoprecipitation (ChIP) analysis Human PBMC were isolated by density gradient separation on Lymphoprep (Axis-Shield PoC As, Norway), and cultured in the presence of Concanavalin A (0.625 μg/ml, ...
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Anti-tumor activity of selective inhibitors of XPO1/CRM1- mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin
... and survivin immunohistochemical staining of tumor sections obtained from orthotopic xenografts revealed increased apoptosis and reduced survivin expression at both nuclear and cytoplasmic cellular ...
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CD1a+ survivin+ dendritic cell infiltration in dermal lesions of systemic sclerosis
... and survivin in skin lesions from patients with SSc and ...of survivin in peripheral blood mononuclear cells (PBMCs) obtained from SSc patients and healthy controls were evaluated using RT-PCR and flow ...
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Inhibitor of Apoptosis Proteins (IAPs) are commonly dysregulated in GIST and can be pharmacologically targeted to enhance the pro-apoptotic activity of imatinib
... the survivin transcriptional repressor YM155 and SMAC mimetics like TL32711 and LCL161 are in advanced clinical development ...the survivin promoter, but binds survivin-regulating transcription ...
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The over-expression of survivin enhances the chemotherapeutic efficacy of YM155 in human hepatocellular carcinoma
... a survivin suppressant, has been tested as a single agent to treat patients with melanoma, lymphoma, lung and prostate cancer ...of survivin in HCC has been reported to correlate with poor prognosis ...
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