Susceptibility loci
Polymorphism in cardiovascular diseases (CVD) susceptibility loci in the azores islands (Portugal)
... Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality worldwide [1]. It comprises several complex disorders, in which dysfunction of the heart and blood vessels is established, and where genetic ...
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Obesity genomics: assessing the transferability of susceptibility loci across diverse populations
... for loci that are transferable across populations of diff erent ...obesity-susceptibility loci, FTO has SNPs that show the strongest associations with obesity- related traits, and the FTO locus is ...
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A two dimensional genome scan for rheumatoid arthritis susceptibility loci
... of susceptibility loci that jointly contribute to rheumatoid arthritis in families recruited by the North American Rheumatoid Arthritis ...between loci 6p21 and 16p12 (two-locus lod score = ...with ...
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Association mapping of susceptibility loci for rheumatoid arthritis
... We analyzed a case-control data set for chromosome 18q from the Genetic Analysis Workshop 15 to detect susceptibility loci for rheumatoid arthritis (RA). A total number of 460 cases and 460 unaffected ...
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Exhaustive screens for disease susceptibility loci incorporating statistical interaction of genotypes: a comparison of likelihood ratio based and Akaike and Bayesian information criteria based methods
... Appropriate strategies to discover disease susceptibility loci in the context of genetic association of complex dis- ease involving large numbers of markers are still under development. Marchini et al. [4] ...
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Genome-wide association study identifies multiple susceptibility loci for glioma
... genetic susceptibility to ...risk loci so far identified for glioma account for 27 and 43% of the familial risk of GBM and non-GBM tumours, respectively, of which ...the loci newly reported in this ...
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A search for non chromosome 6 susceptibility loci contributing to rheumatoid arthritis
... We conducted a search for non-chromosome 6 genes that may increase risk for rheumatoid arthritis (RA). Our approach was to retrospectively ascertain three “ extreme ” subsamples from the North American Rheumatoid ...
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Unravelling the Roles Of susceptibility Loci for Autoimmune Diseases in the Post-GWAS Era
... population data, such as from the analysis of offspring and parental phenotypes, siblings or monozygotic and dizygotic twins (28). This gap is known as missing heritability (28). Even in highly heritable conditions such ...
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Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry.
... Of the 100 reported PCa risk loci, 94 variants are polymorphic with an MAF of 0.05 or greater, 81 are directionally consistent with previous results in other populations (OR > 1), and 47 are nominally ...
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Identification of four new susceptibility loci for testicular germ cell tumour
... risk loci; however, both loci feature SNPs mapping to predicted ...risk loci also have SNPs shown to alter the binding motif of SOX family transcription factors, which regulate germ cell development ...
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Identification of nine new susceptibility loci for endometrial cancer.
... risk loci for endometrial ...significant loci, including a locus on ...ve loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these ...
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Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
... significant loci using a range of annotation tools, databases of functional and eQTL results and previously-published GWAS results (see Online Methods, Supplementary Tables ...
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Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population
... incidence and prevalence of obesity can be predomin- antly explained by lifestyle changes (high intake of fast food and less physical activity), yet some individuals seem to be more susceptible to obesity than others ...
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The genetic basis of multiple sclerosis: a model for MS susceptibility
... identified susceptibility loci, which are unexpectedly high ...caused susceptibility or that this gene is involved with ...true susceptibility allele (see Additional File 1; Appendix S1; ...
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CNV analysis in a large schizophrenia sample implicates deletions at 16p12 1 and SLC1A1 and duplications at 1p36 33 and CGNL1
... several loci have been shown to increase risk for ...novel susceptibility CNV loci, we analyzed 6882 cases and 11 255 controls genotyped on Illumina arrays, most of which have not been used for this ...
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The Clinical Genetics of Prostate Cancer
... genetic susceptibility loci would enable a group of men at high risk of developing prostate cancer to be identified to serve as subjects for chemoprevention ...
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Genetic Loci Controlling Breast Cancer Susceptibility in the Wistar-Kyoto Rat
... four loci are part of a very large set denaturation at 94⬚ for 3 min, followed by 30 cycles of 94⬚ for of mammary cancer susceptibility loci or whether, on 1 min, 50⬚–60⬚ (depending on specific ...
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Interplay between genetics and the environment in the development of celiac disease: perspectives for a healthy life
... ceptibility loci are present in an HLA-DQ2/8–positive individual, disease will almost certainly develop, since there is a failure to regulate the developing gluten-spe- cific T cell ...of susceptibility ...
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ROLE OF GSTP, TCF, ELMO1, TRPC1, IL-10 GENE POLYMORPHISM IN DIABETIC NEPHROPATHY
... nephropathy susceptibility genes, and association analyses have evaluated positional applicant genes under these relation ...at susceptibility loci of dissimilar genes like GST (glutathione-S- ...
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1-s2.0-S1931312819301611-main.pdf
... In a companion study, Ferris et al. further characterized varia- tion in response to influenza A/PR/8/34 in 155 pre-CC lines (Fer- ris et al., 2013). While disease-associated phenotypes (weight loss, viral titer, and ...
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