Sustained Virologic Response
Association of sustained virologic response with reduced progression to liver cirrhosis in elderly patients with chronic hepatitis C
... Objective: We studied the effect of sustained virologic response (SVR) after treatment with pegylated-interferon (PEG-IFN) plus ribavirin on the development of liver cirrhosis in elder[r] ...
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Aspartate aminotransferase to platelet ratio index and sustained virologic response are associated with progression from hepatitis C associated liver cirrhosis to hepatocellular carcinoma after treatment with pegylated interferon plus ribavirin
... Results: A total of 105 patients were enrolled (mean age 58.3±10.4 years). The average follow-up time for each patient was 4.38 years (standard deviation 1.73 years; range 1.13–9.27 years). Fifteen (14.3%) patients ...
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Liver-related morbidity and mortality in patients with chronic hepatitis C and cirrhosis with and without sustained virologic response
... Background: Chronic hepatitis C (CHC) causes liver cirrhosis in 5%–20% of patients, lead- ing to increased morbidity and mortality. This study aimed to estimate liver-related morbidity and mortality among patients with ...
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High sustained virologic response rates of sofosbuvir based regimens in Chinese patients with HCV genotype 3a infection in a real world setting
... AASLD: American Association for the Study of Liver Diseases; AE: Adverse events; ALT: Alanine aminotransferase; APASL: Asian-Pacific Association for the Study of the Liver; AST: Aspartate aminotransferase; CI: Confidence ...
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A study of best positive predictors for sustained virologic response to interferon alpha plus ribavirin therapy in naive chronic hepatitis C patients
... predict response rates of current antiviral ...slow/rapid virologic response rate, their pre-treatment HCV viral load, age, stage of fibrosis, gender, ethnicity and HCV genotypes are factors that may ...
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Decreased hepatocellular carcinoma tumor burden with the achievement of hepatitis C virus sustained virologic response: unlocking the potential of T-cell-mediated immunosurveillance
... achieved sustained virologic response (SVR) with dramatic improvement in HCC tumor bur- den on follow-up imaging without HCC ...T-cell-mediated response and ...
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Effect of abacavir on sustained virologic response to HCV treatment in HIV/HCV co infected patients, Cohere in Eurocoord
... the response to HCV ...with sustained virologic response among patients receiving anti-hepatitis C virus (HCV) treatment in chronically HCV/HIV co-infected patients, COHERE collaboration, 1998 ...
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<p>Prevalence and predictors of occult hepatitis C virus infection among Egyptian patients who achieved sustained virologic response to sofosbuvir/daclatasvir therapy: a multi-center study</p>
... Background: Occult hepatitis C virus (HCV) infection (OCI) is characterized by the detection of HCV-RNA in non-serum reservoirs, such as peripheral blood mononuclear cells (PBMCs) and/or hepatocytes with undetectable ...
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Thyroid disease is a favorable prognostic factor in achieving sustained virologic response in chronic hepatitis C undergoing combination therapy: A nested case control study
... group containing all genotypes (odds ratio, 6.0; 95% confidence interval, 1.5 to 24.6). The likelihood of achieving SVR was increased in individuals with geno- type 1 HCV infection who developed TD (odds ratio, 5.2; 95% ...
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Achieving sustained virologic response in hepatitis C: a systematic review of the clinical, economic and quality of life benefits
... Analysis of clinical studies also showed that patients who achieve SVR have a substantially lower risk of liver-related mortality and overall mortality than non-responders to treatment, irrespective of genotype, setting ...
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The effectiveness of daclatasvir based therapy in European patients with chronic hepatitis C and advanced liver disease
... of sustained virologic response at 12 weeks post treatment was 87% (95% credible interval 75 to 94%) for previously treated genotype 1 patients with decompensated ...
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Meta-analysis: implications of interleukin-28B polymorphisms in spontaneous and treatment-related clearance for patients with hepatitis C
... Additional file 8: Table S6, Genotype and allele frequencies stratified by ethnicity for all the polymorphisms included in the meta-analysis. (a) Sustained virologic response (SVR) and (b) ...
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Top topics in HCV research arena
... showed Sustained Virologic Response (SVR) rates higher than 80% and in some cases higher than 90% with shorter treatment duration, less side effects, more convenient schedules in comparison with ...
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Very rapid virologic response and early HCV response kinetics, as quick measures to compare efficacy and guide a personalized response-guided therapy
... of virologic response to a dual anti-hepatitis C virus (HCV) treatment ...virus response kinetics and the very rapid virologic response (vRVR) rate as quick outcome measures for ...
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FTOrs9939609 polymorphism is associated with metabolic disturbances and response to HCV therapy in HIV/HCV-coinfected patients
... Methods: We carried out a cross-sectional study in 261 patients, of whom 178 were subsequently treated with pegIFN α /RBV therapy. FTO rs9939609 and IFNL3 rs12980275 polymorphisms were genotyped by GoldenGate®. The main ...
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Pharmacogenetics of hepatitis C: transition from interferon-based therapies to direct-acting antiviral agents
... the response of other HCV genotypes has not been ...maximize sustained virologic response rates, prevent progression to liver disease, and increase the overall benefits of therapy with respect ...
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Profile of alisporivir and its potential in the treatment of hepatitis C
... the sustained virologic response at 12 weeks post-treatment (SVR 12 ) in all arms compared with pegylated IFN α and ...rapid virologic response rate value was 29%, 37%, and 42% for arms ...
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Factors associated with uptake, adherence, and efficacy of hepatitis C treatment in people who inject drugs: a literature review
... and sustained virologic response rates comparable with those in nondrug users, drug use per se should not be considered a criterion for exclusion from ...
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Sofosbuvir and Ribavirin in HCV Genotypes 2 and 3
... of sustained virologic response of 45% and 5%, respectively, on the basis of a two-sided continuity- corrected chi-square test at a significance level of ...a sustained virologic ...
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PubMedCentral-PMC4996139.pdf
... shorter duration of therapy with lower doses of ribavirin (RBV) to achieve high rates of sustained virologic response (SVR). Even in the interferon era, data suggested that GT3 was more difficult to ...
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