Synapse Formation
Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation
... To determine which Wnts might be involved in synapse formation, we performed an in situ hybridization screen to identify Wnts that are expressed in the hippocampus during synaptogenesis. In rodents, most ...
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Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
... CLL patients have impaired T cell immune synapse formation. (A) T cell conjugates formed between T cells from CLL patients or age-matched healthy donors and sAg-pulsed autolo- gous CLL B cells or healthy B ...
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Coordinated trafficking of synaptic vesicle and active zone proteins prior to synapse formation
... during synapse assembly, we hypothesized that trafficking of STVs and PTVs might be coordinated even prior to synapse assembly, providing an additional mechanism to facilitate rapid accumulation of the full ...
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Mechanisms of Synapse formation and Maintenance: Insights From the Developing and Diseased Nervous System
... The identification of proteins contained within gel filtration fractions that increase GABAergic axon length, branching, and synaptogenesis (Chapter 3) lays the foundation for several future experiments, with the ...
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Sema7A Signaling is Essential for Activity-Dependent Synapse Formation in the Mouse Olfactory Bulb
... of synapse formation is ...initiating synapse formation followed by dendrite selection in M/T ...regulates synapse formation and dendrite selection in an activity-dependent ...
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Karakatsani, Andromachi (2016): LRP4 regulates dendritic arborization and synapse formation in the central nervous system neurons. Dissertation, LMU München: Fakultät für Biologie
... kidney formation, and placode development (Ahn et ...the formation of most, if not all, postsynaptic specializations (Wu et ...NMJ formation, maintenance and ...during synapse ...
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Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation
... but synapse formation in regions containing aberrant proprioceptive axons and ectopic oligodendrocytes was disrupted in Sema6d ...in synapse formation despite the aberrant positioning of ...
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Caenorhabditis elegans Muscleblind homolog mbl-1 functions in neurons to regulate synapse formation
... action potential, as well as vesicle-associated proteins that allow active zone machinery to interact with synap- tic vesicles [24]. We expressed two fluorescently tagged active zone proteins, UNC-10 (Rim) [25] and SYD-2 ...
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Molecular Mechanisms of Pre- and Postsynaptic Ephb/ephrin-B Signaling in Synapse Formation and Function
... the formation of both pre- and postsynaptic specializations, and interact directly with NMDA-type glutamate ...for formation of presynaptic specializations and the interaction domain between EphBs and NMDA ...
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Opposing Actin Networks Modulate the Mechano-Activation of the Integrin LFA-1 During Immunological Synapse formation
... the formation of a firm adhesive ...stable synapse are all likely to be using similar regulation of the F-actin ...symmetric synapse is very analogous to that of migrating cells, with robust F-actin ...
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PPM-1, a PP2Cα/β phosphatase, Regulates Axon Termination and Synapse Formation in Caenorhabditis elegans
... and synapse formation in Caenorhabditis elegans, Drosophila, zebra fi sh, and ...in synapse formation, axon guidance, axon termination, and postsynaptic GLR-1 ...both synapse ...
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Initiation of synapse formation by Wnt induced MuSK endocytosis
... Synapse formation requires the precise alignment of pre- and postsynaptic ...Neuromuscular synapse development can be subdivided into two functionally distinct phases: an early and a late phase ...
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Mechanisms of Unplugged/Musk-Mediated Neuromuscular Synapse Formation
... in synapse formation in the mammalian CNS, in Drosophia and in ...the formation of a central zone along the anterior-posterior axis of developing ...
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DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs
... the synapse after 10 minutes of synapse ...immune synapse instability, as denoted by the kinapse index (transient interactions index > 1) at 5 and 45 ...
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Human Immunodeficiency Virus Type 1 Virological Synapse Formation in T Cells Requires Lipid Raft Integrity
... Human immunodeficiency virus type 1 (HIV-1) can spread directly between T cells by forming a supramo- lecular structure termed a virological synapse (VS). HIV-1 envelope glycoproteins (Env) are required for VS ...
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Contact-Induced Mitochondrial Polarization Supports HIV-1 Virological Synapse Formation
... Inhibition of VS formation. During our analysis of organelle polarization, we noticed that in addition to blocking mitochon- drial polarization to the VS, there was a general decrease in the frequency of VS that ...
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The Specificity of Synapse Formation by identified Leech Neurones in culture
... Particular pairs of identified neurones isolated from the central nervous system CNS of the leech form chemical synapses; other pairs of cells form nonrectifying electrical junctions, re[r] ...
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Mutations in shaking B prevent electrical synapse formation in the Drosophila giant fiber system
... Fluorescence micrographs showing dorsal views of pupal nervous systems in which Lucifer yellow was injected intracellularly into the right GF.A, At 45 hr APF, the GF is dye-coupled to th[r] ...
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A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation
... To test this possibility, we treated SAD-1 as animals with 1NA-PP1 either throughout establishment until the end of the L2 stage or during the short 30-hour duration of DD synapse forma[r] ...
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Neuronal LRP4 regulates synapse formation in the developing CNS
... The effect of anti-agrin antibodies on dendritic growth suggested that an interaction of LRP4 with TM-agrin might be necessary for the formation of a normal dendritic arbor. To test this further, we investigated ...
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