Synaptic long-term depression (LTD)
MGlu5 receptors and cellular prion protein mediate amyloid ß facilitated synaptic long term depression in vivo
... Ab-facilitated LTD is ...the synaptic plasticity disrupting actions of Ab in vitro 5,8,36 ...of synaptic plasticity, next we assessed the involvement of mGlu5R in both Ab-mediated inhibition of LTP ...
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Effects of PI3Kβ overexpression in the hippocampus on synaptic plasticity and spatial learning
... impaired synaptic plasticity and reduced behavioral ...in synaptic plasticity and hippocampus- dependent behavioral tasks we overexpressed p110 γ , the catalytic subunit of PI3K γ , in the hippocampal CA1 ...
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Non-associative hippocampal long-term depression (LTD) and associative neocortal long-term potentation of synaptic transmission in rat brain slices
... It was shown for the first time that the postsynaptic induction of non-associative LTD was dependent on extracellular Ca^"^. When there was no Ca^"^ included in the bathing medium, high frequency ...
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No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex
... Baseline synaptic responses were first stabilized for at least 20 min before any condi- tioning ...For LTD induction, a classical low-frequency stimulation (LFS) protocol (1 Hz, 900 pulses, with the same ...
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Neurobiological Bases of Learning and Their Role for the Paradigm Shift in Education
... of long term plasticity that controls the process of interneuronal communica- ...tion. LTD is another type of plasticity that balances the process of LTP and allows a refinement of the ...system. ...
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Emulating long-term synaptic dynamics with memristive devices
... observed synaptic modification, as indicated by a positive or negative percentage change in conductance, was recorded for a range of initial conductance ...of synaptic modification was plotted against the ...
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An investigation into the induction of non-associative long-term synaptic depression in the ca1 region of the rat hippocampus in vitro
... in synaptic strength across the various experiments show poor ...of LTD, it must be remembered that these synaptic changes are occurring somewhere along the dendritic tree and not at the ...whether ...
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Changes in synaptic plasticity are associated with electroconvulsive shock-induced learning and memory impairment in rats with depression-like behavior
... of depression-like ...with depression-like behavior (group D), and rats with depression-like behavior undergoing ECS (group ...DE). Depression-like behavior and spatial learning and memory ...
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Differential regulation of synaptic plasticity of the hippocampal and the hypothalamic inputs to the anterior thalamus
... thalamocortical synaptic transmission undergoes potentiation mediated by TrkB receptors (Tsanov and Manahan-Vaughan, ...The long-term response to 900 pulses delivered with rate of 1Hz suggests that ...
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Long-term consequences of in utero irradiated mice indicate proteomic changes in synaptic plasticity related signalling
... this synaptic plasticity ...between long-term potentiation and long-term depression through altered function of glutamatergic NMDA receptors ...enhances long-term ...
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Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro
... Field excitatory postsynaptic potentials (fEPSPs) were recorded in the stratum radiatum of the CA1 area with a glass micropipette (1–3 M Ω ) filled with 2 M NaCl, in response to electrical stimulation of the Schaffer ...
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Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation
... Previously, we found that the rapamycin (200 nM), a spe- cific inhibitor for mTOR, blocked NT-3 induced long- term synapse modulation [6]. Pharmacological inhibitors may elicit side effects in addition to ...
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IMPACT OF CAPITAL STRUCTURE ON FIRM’S VALUE OF SELECTED INDIAN TEXTILE COMPANIES
... Syndicate Ltd, EPS, Fixed asset turnover ratio, Current ratio, Sales growth and Public share-holding are positive determinants of Share ...and Long term debt to total assets are negative determinants ...
7
Protein synthesis in the amygdala, but not the auditory thalamus, is required for consolidation of Pavlovian fear conditioning in rats
... Nevertheless, long-term synaptic plasticity in amygdaloid afferents, such as the auditory thalamus, may contribute to the formation of fear ...in Long± Evans ...
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A Theoretical Model to Explain the Symptoms and Progression of Schizophrenia
... follow long and complex neural pathways resulting in long propagation times relative to the speed of sensory ...loop long before the previous loop has ...
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LONG TERM SOLVENCY ANALYSIS OF A PRIVATE SECTOR COMPANY: A CASE STUDY RELIANCE INDUSTRIES LTD
... the long term creditors of a firm are primarily interested in knowing the firm’s ability to pay regularly the interest on long term borrowings, repayment of the principle amount at the ...
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Comparative analysis of hyperexcitability and synaptic facilitation induced by nerve injury in two populations of mechanosensory neurones of Aplysia californica
... block synaptic transmission, greatly reduce spike activity and eliminate the signs of behavioural sensitization (tonic immobility, suppression of feeding responses) that are often observed after surgery under less ...
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A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1
... that alterations in LTP may be observed with other pat- terns of activation or under different experimental condi- tions or in other pathways. Interestingly, a recent study has shown that deficits in LTP in vitro in mice ...
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Memory and forgetting processes with the firing neuron model
... LTP/ LTD mechanisms. Recently a tagging procedure for LTP/LTD mechanisms as well as a probabilistic spiking neuron model approach were described [8, 13, ...plausible synaptic plasticity mechanism or ...
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Molecular-Genetic Mechanisms of Memory Formation in Mouse Models of Neurodevelopmental and Neuropsychiatric Disorders
... abnormal synaptic connectivity as a key neurobiological feature of ASD that may underlie both social and cognitive impairments (Bakhtiari et al 2012, Wolff et ...
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