Synaptic Vesicle
Synaptic vesicle dynamic changes in a model of fragile X
... Investigating synaptic transmission using microscopy showed an increase of synaptic vesicle recycling in cere- bellar neurons, which is held true for both boutons with weak and strong ...of ...
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Synaptic like microvesicles, synaptic vesicle counterparts in endocrine cells, are involved in a novel regulatory mechanism for the synthesis and secretion of hormones
... mediated exocytosis? Upon stimulation of pinealocytes with KCl, the glutamate concentration in the medium increased in a time-dependent manner, as determined by high-performance liquid chromatography (Yamada et al., ...
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The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
... of synaptic vesicles is severely compro- mised in the absence of p75 NTR are also related to NT signal- ...integral synaptic vesicle proteins has been reported in cultures of neurons derived from ...
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Coordinated trafficking of synaptic vesicle and active zone proteins prior to synapse formation
... clear, synaptic vesicle protein-containing vesicles and dense-core, PTV-like vesicles can be seen apparently tethered together in electron micrographs of young neurons ...these vesicle aggregates ...
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The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer’s disease
... of synaptic transmission may account for neuronal dysfunction and ...for synaptic vesicle exocytosis mediating neurotransmitter release in hippocampal neurons ...of synaptic vesicles after ...
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RIM1α SUMOylation is required for fast synaptic vesicle exocytosis
... of vesicle priming, fusion, and retrieval is very precisely controlled and requires the spatiotemporal coordination of multiple protein- protein ...fast synaptic vesicle ...
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Synapse-Assembly Proteins Maintain Synaptic Vesicle Cluster Stability and Regulate Synaptic Vesicle Transport in Caenorhabditis elegans
... at synaptic sites? Are DCVs, which are not strongly clustered at synaptic sites (Hammarlund et ...the synaptic vesicle transport field is to determine how the activity of KIF1A is ...have ...
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Identification of a human synaptotagmin 1 mutation that perturbs synaptic vesicle cycling
... calcium-binding synaptic vesicle protein that is required for both exocytosis and ...slowed synaptic vesicle fusion kinetics, a finding that agrees with the previously demonstrated role for ...
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Soluble Aβ1–42 increases the heterogeneity in synaptic vesicle pool size among synapses by suppressing intersynaptic vesicle sharing
... A. F. U: Arbiturary fluorescence unit; AD: Alzheimer ’ s disease; A β : Amyloid beta; Ca 2+ : Calcium; CaMKIV: Ca 2+ /calmodulin-dependent protein kinases IV; Diffusion Coeffi: Diffusion coefficient; DIV: Day in vitro; ...
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Epileptic encephalopathy-causing mutations in DNM1 impair synaptic vesicle endocytosis
... dramatic vesicle abnormalities, and our Western blot results indicate that neither mutation affects dimerization, but there is a significant decrease in steady-state levels of the K206N mutant, possibly suggesting ...
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Microtubule and Actin Differentially Regulate Synaptic Vesicle Cycling to Maintain High-Frequency Neurotransmission
... chitecture and functions. During neuronal development, MTs and F-actin play crucial roles in cell motility, axonal growth, and organelle/protein transport to growth cones (Arnette et al., 2016). However, their functional ...
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Mutations in the Drosophila pushover Gene Confer Increased Neuronal Excitability and Spontaneous Synaptic Vesicle Fusion
... Interactions of push with quinidine: The effects of many mutations that affect synaptic transmission as a result of an increase in neuronal excitability are en- hanc[r] ...
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SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation
... Figure 4 | SUMOylation of SynIa modulates its presynaptic targeting and reclustering at the presynapse following stimulation. (a) SUMOylation is required for presynaptic targeting. WT (n¼ 12) or C603S (dead mutant, n ¼ ...
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Common strength and localization of spontaneous and evoked synaptic vesicle release sites
... spontaneous vesicle release also under- went evoked vesicle recycling ...released vesicle to estimate the time to turn over the whole recycling pool of vesicles and thus to proof the kinetics ...
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Stieglitz, Marc Sebastian (2018): The control of neuronal activity and behavior by members of the HCN and TPC family. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... since synaptic vesicle release is often dependent on calcium signals, increases in local calcium could lead to more vesicles fusing with the presynaptic membrane and releasing their contents into the ...
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A Genetic Screen for Synaptic Transmission Mutants Mapping to the Right Arm of Chromosome 3 in Drosophila
... because the photoreceptor neurons fail to properly pro- removes the genes encoding the synaptic vesicle-recy- ject axons to their target cells in the optic lobe. The cling component LAP and the ...
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Extended Synaptotagmin Localizes to Presynaptic ER and Promotes Neurotransmission and Synaptic Growth in Drosophila
... at synaptic terminals with loss or overexpression of ...other synaptic compartments including active zones, synaptic vesicle pools, periactive zone regions, and the neuronal PM (Figure 2, E ...
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Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer’s disease
... in synaptic activity are one of the causes of synaptic toxicity ...dysfunctional synaptic machin- ery could be an after-effect of impaired synaptic vesicle ...impair synaptic ...
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Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer’s disease neuropathology
... that synaptic function is ...hand, synaptic vesicle Zn 2+ was increased in both AD and NDAN, whereas ZnT3 expression was decreased in AD but preserved in NDAN ...of synaptic and cognitive ...
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A Presynaptic Regulatory System Acts Transsynaptically via Mon1 to Regulate Glutamate Receptor Levels in Drosophila
... regulating synaptic development and ...on synaptic vesicles, and both play a role in regulating neurotransmitter release (Fischer Von Mollard et ...maintain synaptic vesicle size by preventing ...
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