synovial fibroblasts
Synovial fibroblasts in 2017
... and synovial fibroblasts are only some examples of stromal cells that have been shown to express innate immune recep- tors, in particular toll-like receptors ...
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MicroRNAs interfere with DNA methylation in rheumatoid arthritis synovial fibroblasts
... In RASF treated with L-methionine, DNMT3B tran- scripts increased; this could explain at least in part the remethylation. However, the correlation analysis doesn ’ t show a positive relationship. This might be due to a ...
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Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts
... RA, synovial fibroblasts in the synovial lining, are believed to be particularly important in the pathogenesis of disease because they recruit leukocytes into the synovium and secrete ...
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The proinflammatory cytokines IL 1β and TNF α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2 ETS1 pathway
... of synovial fibroblasts by activating the MAPK pathways ...of synovial fibroblasts with 10% fetal bovine serum (FBS) highly activates all these MAPKs, we first starved the mouse ...
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Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation
... 13kdap = 13kDa differentiation-associated protein; Apaf-1 = apoptotic protease-activating factor-1; AZI = antizyme inhibitor; BCIP = 5-bromo-4- chloro-3-indolyl-phosphate, 4-toluidine salt; ECM = extracellular matrix; ...
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Fibroblast biology: Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
... activated synovial fibroblasts, as part of a complex cellular network, play an important role in the pathogenesis of rheumatoid ...arthritis synovial fibroblasts (RA-SFs) do not merely respond ...
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Connexin43 enhances the expression of osteoarthritis associated genes in synovial fibroblasts in culture
... One means by which cells and tissues coordinate func- tion is via cell-to-cell communication through gap junc- tion proteins. Gap junctions are made up of connexin monomers that assemble to form a hemichannel. Gap ...
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Kinesin like protein CENP E is upregulated in rheumatoid synovial fibroblasts
... improvements including RAP-PCR have proved to have both efficiency and reliability in examination of differentially regulated genes. The results of the present study reveal that RAP-PCR is a suitable method to identify ...
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Characterization of the interaction between monocytes and synovial fibroblasts in rheumatoid arthritis
... the fibroblasts-like synoviocytes) and contains large amounts of rough endoplasmic reticulum with few cell processes and vacuoles, but more developed nucleoli indicating protein synthesis (Cutolo et ...normal ...
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Cultured human synovial fibroblasts rapidly metabolize kinins and neuropeptides
... human synovial lining cells may regulate intraarticular levels of kinins and neuropeptides via degradation by cell surface-associated ...human synovial fibroblasts to kinins and substance P, in the ...
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TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts
... that fibroblasts are under continu- ous ER stress that is increased by TNF a ...The fibroblasts use both the proteasome and autophagy pathways to clear aberrant proteins and promote cell ...control ...
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The activin follistatin anti inflammatory cycle is deregulated in synovial fibroblasts
... on synovial fibroblasts. a Activin A staining of RA synovial tissue compared to b OA synovial tissue (representative stainings, n = 4 ...OA synovial tissue ( n = 3) when compared to the ...
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Serum amyloid A (SAA3) produced by rabbit synovial fibroblasts treated with phorbol esters or interleukin 1 induces synthesis of collagenase and is neutralized with specific antiserum
... We report that nucleic acid sequence analysis of a full-length cDNA clone for a rabbit serum amyloid A (SAA)-like protein has identified this protein as more closely related to SAA3 than to SAA1. SAA3 induced collagenase ...
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Activated Protein C Inhibits Proliferation and Tumor Necrosis Factor α-Stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts
... However, further studies are required using synovial fibroblasts from normal and OA patients as well as RA synovium from different joints to confirm the selec- tive effects of APC. This study provides the ...
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Apoptosis is not the major death mechanism induced by celecoxib on rheumatoid arthritis synovial fibroblasts
... Celecoxib reduces viability and proliferation of synovial fibroblasts extracted from patients with rheumatoid arthritis (RA). (a) Fibroblast-like synovio- cytes (FLSs) of patients with RA were cultured for ...
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RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis
... of synovial fibroblasts (SFs) [3,4]. Rheumatoid arthritis synovial fibroblasts (RASFs) produce additional cytokines, che- mokines and matrix-degrading enzymes which ultimately leads to the ...
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Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
... B synovial cells” to describe the fibroblast-like ...“synovial fibroblasts (SF)” to describe the cells derived from synovium in his study of RA and non-RA ...ovial fibroblasts” can be commonly ...
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Constitutive expression of a 92 kD gelatinase (type V collagenase) by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines
... Synovial fibroblasts freshly isolated from the rheumatoid joint are characterized by their marked connective tissue degradative ...lung fibroblasts and is immunologically cross-reactive with a type V ...
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Cytokine mRNA and protein expression in primary culture and repeated passage synovial fibroblasts from patients with rheumatoid arthritis
... remaining synovial tissue was used for further preparation. Isolation of synovial fibroblasts and skin fibroblasts Isolation of SFB from the RA synovial membrane and of skin FB was ...
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Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage
... RASF are also capable of transmigration to a second- ary site of cartilage implantation as previously described [6]. Following engraftment we found that RASF at the secondary site self-organized into layers of SF ...
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